Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Helmut, Bischof"'
Autor:
Bernhard Groschup, Gian Marco Calandra, Constanze Raitmayr, Joshua Shrouder, Gemma Llovera, Asal Ghaffari Zaki, Sandra Burgstaller, Helmut Bischof, Emrah Eroglu, Arthur Liesz, Roland Malli, Severin Filser, Nikolaus Plesnila
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Neuronal activity is accompanied by a net outflow of potassium ions (K+) from the intra- to the extracellular space. While extracellular [K+] changes during neuronal activity are well characterized, intracellular dynamics have been less well
Externí odkaz:
https://doaj.org/article/5ae63432000d4fcca11bba7269b0eb71
Autor:
Helmut Bischof, Selina Maier, Piotr Koprowski, Bogusz Kulawiak, Sandra Burgstaller, Joanna Jasińska, Kristian Serafimov, Monika Zochowska, Dominic Gross, Werner Schroth, Lucas Matt, David Arturo Juarez Lopez, Ying Zhang, Irina Bonzheim, Florian A Büttner, Falko Fend, Matthias Schwab, Andreas L Birkenfeld, Roland Malli, Michael Lämmerhofer, Piotr Bednarczyk, Adam Szewczyk, Robert Lukowski
Publikováno v:
eLife, Vol 12 (2024)
Alterations in the function of K+ channels such as the voltage- and Ca2+-activated K+ channel of large conductance (BKCa) reportedly promote breast cancer (BC) development and progression. Underlying molecular mechanisms remain, however, elusive. Her
Externí odkaz:
https://doaj.org/article/60f91b8d7664470fa1f56e117e4caef3
Autor:
David Skrabak, Helmut Bischof, Thomas Pham, Peter Ruth, Rebekka Ehinger, Lucas Matt, Robert Lukowski
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Mutations of the Na+-activated K+ channel Slack (KCNT1) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report increased severity of acute kainic acid-induced seizures in adult and juvenile Slack knocko
Externí odkaz:
https://doaj.org/article/a6c08612daa049a9a70afd552cb8e96a
Autor:
Dominic Gross, Helmut Bischof, Selina Maier, Katharina Sporbeck, Andreas L. Birkenfeld, Roland Malli, Peter Ruth, Tassula Proikas-Cezanne, Robert Lukowski
Publikováno v:
Cell Death and Disease, Vol 13, Iss 10, Pp 1-14 (2022)
Abstract Ca2+-activated K+ channels of intermediate conductance (IK) are frequently overexpressed in breast cancer (BC) cells, while IK channel depletion reduces BC cell proliferation and tumorigenesis. This raises the question, of whether and mechan
Externí odkaz:
https://doaj.org/article/36dbb1c4c62044baa46ffea7e80eab74
Autor:
Sandra Burgstaller, Teresa R. Wagner, Helmut Bischof, Sarah Bueckle, Aman Padamsey, Desiree Frecot, Philipp D. Kaiser, David Skrabak, Roland Malli, Robert Lukowski, Ulrich Rothbauer
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104907- (2022)
Summary: Ion and analyte changes in the tumor microenvironment (TME) alter the metabolic activity of cancer cells, promote tumor cell growth, and impair anti-tumor immunity. Consequently, accurate determination and visualization of extracellular chan
Externí odkaz:
https://doaj.org/article/c93a87783219431f8eb4f7cb90e33442
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100843- (2021)
Summary: Investigating dynamic changes of mitochondrial ATP and cytosolic glucose levels of single living cells over time by genetically encoded biosensors provides an informative readout of their metabolic activities. Here, we describe how to monito
Externí odkaz:
https://doaj.org/article/1099ab079b42471eaec4e3d06044c602
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100876- (2021)
Summary: We have recently demonstrated that the activity of hexokinase 2 is dependent on the intracellular potassium ion (K+) concentration ([K+]). To analyze the K+ dependency of the cell metabolism in cell populations, we used an extracellular flux
Externí odkaz:
https://doaj.org/article/ea2467c89aaf4399acb94c2aba70b90b
Autor:
Benjamin Gottschalk, Christiane Klec, Gerd Leitinger, Eva Bernhart, René Rost, Helmut Bischof, Corina T. Madreiter-Sokolowski, Snježana Radulović, Emrah Eroglu, Wolfgang Sattler, Markus Waldeck-Weiermair, Roland Malli, Wolfgang F. Graier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Proper mitochondrial structure is critical for normal function. Here, the authors show with SIM that the mitochondrial Ca2+ uniporter complex and localization of component MICU1 is critical to maintaining cristae junction stability and overall mitoch
Externí odkaz:
https://doaj.org/article/6ac9bbcf957c4a56ad8f56403898e532
Autor:
Helmut Bischof, Sandra Burgstaller, Anna Springer, Lucas Matt, Thomas Rauter, Olaf A. Bachkönig, Tony Schmidt, Klaus Groschner, Rainer Schindl, Tobias Madl, Nikolaus Plesnila, Robert Lukowski, Wolfgang F. Graier, Roland Malli
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102468- (2021)
Externí odkaz:
https://doaj.org/article/aa5c9905364c4c30bea6ea7a049a7987
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100048- (2020)
Summary: The metabolic activity of cells is interrelated with cell signaling, functions, and fate. Uncontrolled cancer cell proliferation requires metabolic adaptations. Research focusing on understanding the characteristics of cell metabolism is cru
Externí odkaz:
https://doaj.org/article/d100ae1634654ce78b67f026361e7ab9