Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Helmtrud I. Roach"'
Autor:
Latifa Alghfeli, Divyasree Parambath, Shaista Manzoor, Helmtrud I. Roach, Richard O.C. Oreffo, Ahmed T. El-Serafi
Publikováno v:
Bone Reports, Vol 15, Iss , Pp 101143- (2021)
Background: Efficient differentiation of stem cells into three-dimensional (3D) osteogenic construct is still an unmet challenge. These constructs can be crucial for patients with bone defects due to congenital or traumatic reasons. The modulation of
Externí odkaz:
https://doaj.org/article/dd329a1753794badbf3377318595f849
Autor:
Eiji Itoi, Richard O.C. Oreffo, Kei Imagawa, Ko Hashimoto, María C. de Andrés, Miguel Otero, Mary B. Goldring, Helmtrud I. Roach
Publikováno v:
Arthritis & Rheumatology. 66:3040-3051
Objective To investigate whether the changes in collagen gene expression in osteoarthritic (OA) human chondrocytes are associated with changes in the DNA methylation status in the COL2A1 enhancer and COL9A1 promoter. Methods Expression levels were de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2549d0d049aa4fcc6cbff0e0866c0b75
https://doi.org/10.1002/art.38774
https://doi.org/10.1002/art.38774
Autor:
Antonio González, María C. de Andrés, Mary B. Goldring, Richard O.C. Oreffo, Ko Hashimoto, Helmtrud I. Roach, Kei Imagawa
Publikováno v:
RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
Servizo Galego de Saúde (SERGAS)
Idiopathic osteoarthritis (OA) is a late-onset, complex disease of the joint, characterized by progressive failure of the extracellular cartilage matrix, along with changes in the synovium and subchondral bone. A key feature of OA is the catabolic de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f81fa4b18edf298013c2d58269bf5b
https://doi.org/10.1002/art.37806
https://doi.org/10.1002/art.37806
Epidemiological studies suggest that environmental influences such as maternal nutrition, programme skeletal growth during intrauterine and early postnatal life. However, the mechanism whereby the skeletal growth trajectory is modified remains unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec4a57daf7a59ae1cd26ced2abc2d1aa
https://ora.ox.ac.uk/objects/uuid:272644a5-e064-4134-af17-4bee7429962b
https://ora.ox.ac.uk/objects/uuid:272644a5-e064-4134-af17-4bee7429962b
Publikováno v:
European Cells & Materials, Vol 21, Pp 558-567 (2011)
Europe PubMed Central
Europe PubMed Central
This study has examined the osteogenic and chondrogenic differentiation of human foetal femur-derived cells in 3-dimensional pellet cultures. After culture for 21-28 days in osteogenic media, the pellets acquired a unique configuration that consisted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2dea4d8f3a3e26b5d3f30680de9911
https://doi.org/10.22203/ecm.v021a42
https://doi.org/10.22203/ecm.v021a42
Autor:
M.C. de Andrés, Eiji Itoi, Richard O.C. Oreffo, Mary B. Goldring, Kei Imagawa, Dominic Pitt, Helmtrud I. Roach, Ko Hashimoto
Publikováno v:
Biochemical and Biophysical Research Communications. 405:362-367
Objective: Idiopathic osteoarthritis is the most common form of osteoarthritis (OA) world-wide and remains the leading cause of disability and the associated socio-economic burden in an increasing aging population. Traditionally, OA has been viewed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1363e1ef2bc485dbf5f601a489d281
https://doi.org/10.1016/j.bbrc.2011.01.007
https://doi.org/10.1016/j.bbrc.2011.01.007
Publikováno v:
Epigenetics. 2:86-91
Heterogeneity of cells with respect to the DNA methylation status at a specific CpG site is a problem when assessing methylation status. We have developed a simple two-step method for the quantification of the percent of cells that display methylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0d43a5edf45a37b57b8ff7ff2cb70a
https://doi.org/10.4161/epi.2.2.4203
https://doi.org/10.4161/epi.2.2.4203
Autor:
Helmtrud I. Roach, Thomas Aigner
Publikováno v:
Osteoarthritis and Cartilage. 15:128-137
Summary Objective To review the current knowledge of the mechanism of DNA methylation, its association with transcriptional silencing, possible mechanisms of hyper- and hypomethylation and how epigenetic changes may relate to the pathogenesis of oste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d916d7dc33111e8081278f715211a149
https://doi.org/10.1016/j.joca.2006.07.002
https://doi.org/10.1016/j.joca.2006.07.002
Publikováno v:
Journal of Bone and Joint Surgery. 88:155-161
Background: An investigation of matrix metalloproteinase-9 (MMP-9) and its influence on vascular invasion in the secondary ossification center at the chondroepiphysis of developing long bones was undertaken. The effect of MMP-9 was compared with that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b02824b660a773db8a5cb9303cd860
https://doi.org/10.2106/jbjs.f.00542
https://doi.org/10.2106/jbjs.f.00542
Publikováno v:
Current Rheumatology Reviews. 2:221-232
In the last few years there has been an explosion of research into epigenetics and, in particular, the roles of DNA methylation in the normal functioning of the mammalian organism as well as whether changes in methylation status contribute to or caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f42b613b776624cb2fdb9970cfea24e
https://doi.org/10.2174/157339706778019647
https://doi.org/10.2174/157339706778019647