[Early Detection Of Type 1 Diabetes By Islet Autoantibody Screening: A Position Paper Of The Fr1daplex Project Leaders And Training Centres, Bvkj Bavaria And Paednetz (Registered) Bavaria].

Autor: Achenbach P; Institut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.; Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany., Berner R; Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Kinder- und Jugendmedizin, Technische Universität Dresden, Dresden, Germany., Bonifacio E; Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany., Brämswig S; Klinik für Kinder- und Jugendmedizin, RoMed Klinikum Rosenheim, Rosenheim, Germany., Braig S; Klinik für Kinder und Jugendliche, Klinikum Bayreuth GmbH, Bayreuth, Germany., Dunstheimer D; Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Augsburg, Augsburg, Germany., Ermer U; Kinder- und Jugendmedizin, Ameos Klinikum St. Elisabeth Neuburg, Neuburg an der Donau, Germany., Ewald D; Bahnhofstr. 24, Kinderarztpraxis, Regensburg, Germany., Gemulla G; Universitätsklinikum Carl Gustav Carus, Klinik und Poliklinik für Kinder- und Jugendmedizin, Technische Universität Dresden, Dresden, Germany.; Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany., Hauer J; Zentrum für Kinder und Jugendmedizin, München Klinik und Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany., Haupt F; Institut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.; Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany., Haus G; Hans-Mielich-Str. 35, Kinderarztpraxis, München, Germany., Hubmann M; Steinweg 6, Kinderarztpraxis, Zirndorf, Germany., Hummel S; Institut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.; Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany., Kandler M; Ottilienstr. 1, Kinderarztpraxis, Regensburg, Germany., Kordonouri O; Diabetologie, Endokrinologie und Allgemeine Pädiatrie, Kinder- und Jugendkrankenhaus AUF DER BULT, Hannover, Germany., Lange K; Medizinische Psychologie, Medizinische Hochschule Hannover, Hannover, Germany., Laub O; Happinger Str. 98, Kinderarztpraxis, Rosenheim, Germany., Lorrmann A; Kinder und Jugendmedizin, KJF Klinik Josefinum GmbH, Augsburg, Germany., Nellen-Hellmuth N; Kinderdiabetologie, MVZ Leopoldina GmbH, Schweinfurt, Germany., Sindichakis M; Klinik für Kinder- und Jugendmedizin, Kinderdiabetologie, Klinikum Traunstein, Traunstein, Germany., von dem Berge T; Diabetologie, Endokrinologie und Allgemeine Pädiatrie, Kinder- und Jugendkrankenhaus AUF DER BULT, Hannover, Germany., Warncke K; Zentrum für Kinder und Jugendmedizin, München Klinik und Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany., Weber L; Klinik für Kinderheilkunde und Jugendmedizin, Kinderdiabetologie, Klinikum Kempten-Oberallgau GmbH, Kempten, Germany., Winkler C; Institut für Diabetesforschung, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt, Neuherberg, Germany.; Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany., Wintermeyer P; Ingolstädterstr. 166, Kinderarztpraxis, München, Germany., Ziegler AG; Institute of Diabetes Research, Helmholtz Center Munich German Research Center for Environmental Health, Neuherberg, Germany.; Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München Fakultät für Medizin, Munchen, Germany.

Publikováno v: Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) [Gesundheitswesen] 2024 Jul 29. Date of Electronic Publication: 2024 Jul 29.

Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome.

Autor: Brat C; Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt/Main 60590 Hesse, Germany., Huynh Phuoc HP; Department Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen, 63225 Hesse, Germany., Awad O; Department Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen, 63225 Hesse, Germany., Parmar BS; Institute of Biochemistry II, University Hospital Frankfurt, Goethe-University, Frankfurt/Main, 60590 Hesse, Germany., Hellmuth N; Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt/Main 60590 Hesse, Germany., Heinicke U; Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt/Main 60590 Hesse, Germany., Amr S; Institute of Biochemistry II, University Hospital Frankfurt, Goethe-University, Frankfurt/Main, 60590 Hesse, Germany., Grimmer J; Department of Chemistry, RPTU Kaiserslautern-Landau, Kaiserslautern, 67663 Rhineland-Palatinate, Germany., Sürün D; Medical Systems Biology, Faculty of Medicine, TU Dresden, Dresden, 01307 Saxony, Germany., Husnjak K; Institute of Biochemistry II, University Hospital Frankfurt, Goethe-University, Frankfurt/Main, 60590 Hesse, Germany., Carlsson M; Division of Food Chemistry and Toxicology, Department of Chemistry, RPTU Kaiserslautern-Landau, Kaiserslautern, 67663 Rhineland-Palatinate, Germany., Fahrer J; Division of Food Chemistry and Toxicology, Department of Chemistry, RPTU Kaiserslautern-Landau, Kaiserslautern, 67663 Rhineland-Palatinate, Germany., Bauer T; Department Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen, 63225 Hesse, Germany., Krieg SC; Department of Chemistry, RPTU Kaiserslautern-Landau, Kaiserslautern, 67663 Rhineland-Palatinate, Germany., Manolikakes G; Department of Chemistry, RPTU Kaiserslautern-Landau, Kaiserslautern, 67663 Rhineland-Palatinate, Germany., Zacharowski K; Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt/Main 60590 Hesse, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe-University, Frankfurt/Main, 60438 Hesse, Germany., Münch C; Institute of Biochemistry II, University Hospital Frankfurt, Goethe-University, Frankfurt/Main, 60590 Hesse, Germany., Maier TJ; Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt/Main 60590 Hesse, Germany; Department Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen, 63225 Hesse, Germany., Roos J; Department of Anesthesia, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt/Main 60590 Hesse, Germany; Department Safety of Medicinal Products and Medical Devices, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen, 63225 Hesse, Germany. Electronic address: jessica.roos@pei.de.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2023 Oct 19; Vol. 30 (10), pp. 1277-1294.e12. Date of Electronic Publication: 2023 Jul 19.

Understanding Daily, Emotional, and Physical Burdens and Needs of Parents Caring for Children with Type 1 Diabetes.

Autor: Saßmann H; Hannover Medical School, Medical Psychology, Hannover, Germany., Kim-Dorner SJ; Hannover Medical School, Medical Psychology, Hannover, Germany., Berndt V; Sana Hospital Group Berlin-Brandenburg, Social-Pediatric Centre Lichtenberg, Berlin, Germany., Biester T; Children's Hospital AUF DER BULT, Diabetes-Centre for Children and Adolescents, Hannover, Germany., Dehn-Hindenberg A; Hannover Medical School, Medical Psychology, Hannover, Germany., Heidtmann B; Catholic Children's Hospital Wilhelmstift, Hamburg, Germany., Jorch N; Bielefeld University, University Clinic for Pediatrics, Evang. Klinikum Bethel, Bielefeld, Germany., Lilienthal E; University Clinic Ruhr-University Bochum, University Children's Hospital, Bochum, Germany., Nellen-Hellmuth N; Leopoldina-Hospital Schweinfurt, Clinic for Pediatrics, Schweinfurt, Germany., Neu A; Eberhard Karls University Tübingen, Pediatric Endocrinology and Diabetes, Tübingen, Germany., Schaaf K; Elisabeth-Hospital-Essen, Pediatrics, Essen, Germany., Ziegler R; Diabetes Clinic for Children and Adolescents Münster, Münster, Germany., Lange K; Hannover Medical School, Medical Psychology, Hannover, Germany.

Publikováno v: Journal of diabetes research [J Diabetes Res] 2022 Dec 13; Vol. 2022, pp. 9604115. Date of Electronic Publication: 2022 Dec 13 (Print Publication: 2022).

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase

Autor: Roos, J., Peters, M., Maucher, I.V., Kühn, B., Fettel, J., Hellmuth, N., Brat, C., Sommer, B., Urbschat, A., Piesche, M., Vogel, A., Proschak, E., Blöcher, R., Buscató, E., Häfner, A.-K., Matrone, C., Werz, O., Heidler, J., Wittig, I., Angioni, C., Geisslinger, G., Parnham, M.J., Zacharowski, K., Steinhilber, D., Maier, T.J.

Aims: 5-Lipoxygenase (5-LO) is the key enzyme of leukotriene (LT) biosynthesis and is critically involved in a number of inflammatory diseases such as arthritis, gout, bronchial asthma, atherosclerosis, and cancer. Because 5-LO contains critical nucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::e807cdcecbc9a504fca6b5eaad0936ce
https://publica.fraunhofer.de/handle/publica/254342

Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids.

Autor: Hellmuth N; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany., Brat C; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany., Awad O; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.; Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany., George S; Institute of Pharmaceutical Chemistry, Goethe-University, Frankfurt, Germany., Kahnt A; Institute of Pharmaceutical Chemistry, Goethe-University, Frankfurt, Germany., Bauer T; Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany., Huynh Phuoc HP; Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe-University, Frankfurt, Germany., Angioni C; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, Goethe-University, Frankfurt, Germany., Hassan M; Department of Chemistry, TU Kaiserslautern, Kaiserslautern, Germany.; Department of Chemistry, Faculty of Science, Aswan University, Aswan, Egypt., Hock KJ; Department of Chemistry, TU Kaiserslautern, Kaiserslautern, Germany., Manolikakes G; Department of Chemistry, TU Kaiserslautern, Kaiserslautern, Germany., Zacharowski K; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany., Roos J; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.; Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany., Maier TJ; Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt, Germany.; Paul-Ehrlich Institute, Federal Institute for Vaccines and Biomedicines, Langen, Germany.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2021 Nov 18; Vol. 12, pp. 715076. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2021).