A method to image brain tissue frozen at autopsy

Autor: Govind Nair, Roy Sun, Hellmut Merkle, Qing Xu, Kyra Hoskin, Kendyl Bree, Stephen Dodd, Alan P. Koretsky

Publikováno v: NeuroImage, Vol 296, Iss , Pp 120680- (2024)

Magnetic Resonance Imaging (MRI) can provide the location and signal characteristics of pathological regions within a postmortem tissue block, thereby improving the efficiency of histopathological studies. However, such postmortem-MRI guided histopat

Externí odkaz: https://doaj.org/article/53239d8cc14845cb8ec039eb979552d9

Laminar differences in functional oxygen metabolism in monkey visual cortex measured with calibrated fMRI

Autor: Yvette Bohraus, Hellmut Merkle, Nikos K. Logothetis, Jozien Goense

Publikováno v: Cell Reports, Vol 42, Iss 11, Pp 113341- (2023)

Summary: Blood-oxygenation-level-dependent functional magnetic resonance imaging (BOLD fMRI) of cortical layers relies on the hemodynamic response and is biased toward large veins on the cortical surface. Functional changes in the cerebral metabolic

Externí odkaz: https://doaj.org/article/5f34b441141d4984b87e17043a4e253a

Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

Autor: Shun Kishimoto, Jeffrey R Brender, Daniel R Crooks, Shingo Matsumoto, Tomohiro Seki, Nobu Oshima, Hellmut Merkle, Penghui Lin, Galen Reed, Albert P Chen, Jan Henrik Ardenkjaer-Larsen, Jeeva Munasinghe, Keita Saito, Kazutoshi Yamamoto, Peter L Choyke, James Mitchell, Andrew N Lane, Teresa WM Fan, W Marston Linehan, Murali C Krishna

Publikováno v: eLife, Vol 8 (2019)

Metabolic differences among and within tumors can be an important determinant in cancer treatment outcome. However, methods for determining these differences non-invasively in vivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we dem

Externí odkaz: https://doaj.org/article/55e2be4d50894222ab3e33462c3754bc

Dynamic Imaging of Glucose and Lactate Metabolism by 13C-MRS without Hyperpolarization

Autor: Jeeva Munasinghe, Peter L. Choyke, Galen D. Reed, Jeffrey R. Brender, Murali C. Krishna, Jan Henrik Ardenkjær-Larsen, James B. Mitchell, Ralph E. Hurd, Keita Saito, Shun Kishimoto, Kazutoshi Yamamoto, Albert P. Chen, Tomohiro Seki, Nobu Oshima, Hellmut Merkle

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Brender, J R, Kishimoto, S, Merkle, H, Reed, G, Hurd, R E, Chen, A P, Ardenkjær-Larsen, J H, Munasinghe, J, Saito, K, Seki, T, Oshima, N, Yamamoto, K, Choyke, P L, Mitchell, J & Krishna, M C 2019, ' Dynamic Imaging of Glucose and Lactate Metabolism by C-13-MRS without Hyperpolarization ', Scientific Reports, vol. 9, no. 1, 3410 . https://doi.org/10.1038/s41598-019-38981-1

Metabolic reprogramming is one of the defining features of cancer and abnormal metabolism is associated with many other pathologies. Molecular imaging techniques capable of detecting such changes have become essential for cancer diagnosis, treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96facdedfd8ba3ce49e0419474af6ae
http://link.springer.com/article/10.1038/s41598-019-38981-1

First-in-Human Intraoperative MRI Coil for High-Resolution Imaging during Transsphenoidal Surgery

Autor: John A. Butman, Prashant Chittiboina, Alan P. Koretsky, Elizabeth Hogan, Joelle E. Sarlls, Gretchen Scott, Hellmut Merkle, Lalith Talagala

Publikováno v: 30th Annual Meeting North American Skull Base Society.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33e7b10380c3c11529b3e55e5182f243
https://doi.org/10.1055/s-0040-1702521