Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.

Autor: Helliwell, Matthew V.^1,2 (AUTHOR) mhelliwell1@yahoo.com, Zhang, Yihong² (AUTHOR) aziza.elharchi@bristol.ac.uk, El Harchi, Aziza² (AUTHOR), Dempsey, Christopher E.¹ (AUTHOR) c.dempsey@bristol.ac.uk, Hancox, Jules C.² (AUTHOR) jules.hancox@bristol.ac.uk

Publikováno v: Pharmaceuticals (14248247). Sep2023, Vol. 16 Issue 9, p1204. 20p.

Structural implications of hERG K+ channel block by a high affinity minimally-structured blocker

Autor: Helliwell, Matthew V, Zhang, Yihong, El Harchi, Aziza, Du, Chunyun, Hancox, Jules C, Dempsey, Christopher E

Publikováno v: Helliwell, M V, Zhang, Y, El Harchi, A, Du, C, Hancox, J C & Dempsey, C E 2018, ' Structural implications of hERG K+ channel block by a high affinity minimally-structured blocker ', Journal of Biological Chemistry, vol. 293, no. 18, pp. 7040-7057 . https://doi.org/10.1074/jbc.RA117.000363

Cardiac potassium channels encoded byhuman Ether-à-go-go Related Gene (hERG)are major targets for structurally diverse drugs associated with acquired long QT syndrome. This study characterized hERG channel inhibition by a minimally structured high a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::e4472d81dd3c6f15fae9918e0d057f60
https://hdl.handle.net/1983/5086088a-9ce4-4b97-b755-0bd960e1ec3c

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