Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Hellen Kuasne"'
Autor:
Elena Kuzmin, Toby M. Baker, Tom Lesluyes, Jean Monlong, Kento T. Abe, Paula P. Coelho, Michael Schwartz, Joseph Del Corpo, Dongmei Zou, Genevieve Morin, Alain Pacis, Yang Yang, Constanza Martinez, Jarrett Barber, Hellen Kuasne, Rui Li, Mathieu Bourgey, Anne-Marie Fortier, Peter G. Davison, Atilla Omeroglu, Marie-Christine Guiot, Quaid Morris, Claudia L. Kleinman, Sidong Huang, Anne-Claude Gingras, Jiannis Ragoussis, Guillaume Bourque, Peter Van Loo, Morag Park
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113988- (2024)
Summary: The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. A
Externí odkaz:
https://doaj.org/article/037f03f6925f4a5d977165ac992225f6
Autor:
Naiade Calanca, Ana Lucia Noronha Francisco, Daniela Bizinelli, Hellen Kuasne, Mateus Camargo Barros Filho, Bianca Campos Troncarelli Flores, Clóvis Antonio Lopes Pinto, Claudia Aparecida Rainho, Milena Botelho Pereira Soares, Fabio Albuquerque Marchi, Luiz Paulo Kowalski, Silvia Regina Rogatto
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115559- (2023)
Oral cavity squamous cell carcinoma (OSCC) is a complex and dynamic disease characterized by clinicopathological and molecular heterogeneity. Spatial and temporal heterogeneity of cell subpopulations has been associated with cancer progression and im
Externí odkaz:
https://doaj.org/article/5d77f3e1e09e428e8d390ea47ed26220
Autor:
Ipshita Nandi, Harvey W. Smith, Virginie Sanguin-Gendreau, Linjia Ji, Alain Pacis, Vasilios Papavasiliou, Dongmei Zuo, Stella Nam, Sherif S. Attalla, Sung Hoon Kim, Sierra Lusson, Hellen Kuasne, Anne-Marie Fortier, Paul Savage, Constanza Martinez Ramirez, Morag Park, John A. Katzenellenbogen, Benita S. Katzenellenbogen, William J. Muller
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor outcomes, yet the underlying mechanisms are incompletely understood. Here, we have shown that deletion of c-Src in a genetically engineered model mimicking the lumina
Externí odkaz:
https://doaj.org/article/6febccb2e0664106aef4e61bab5617dd
Autor:
Stephanie P. Totten, Young Kyuen Im, Eduardo Cepeda Cañedo, Ouafa Najyb, Alice Nguyen, Steven Hébert, Ryuhjin Ahn, Kyle Lewis, Benjamin Lebeau, Rachel La Selva, Valérie Sabourin, Constanza Martínez, Paul Savage, Hellen Kuasne, Daina Avizonis, Nancy Santos Martínez, Catherine Chabot, Adriana Aguilar-Mahecha, Marie-Line Goulet, Matthew Dankner, Michael Witcher, Kevin Petrecca, Mark Basik, Michael Pollak, Ivan Topisirovic, Rongtuan Lin, Peter M. Siegel, Claudia L. Kleinman, Morag Park, Julie St-Pierre, Josie Ursini-Siegel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregu
Externí odkaz:
https://doaj.org/article/e78e979f7f9a43d280222791ea6273df
Autor:
Sarah Santiloni Cury, Hellen Kuasne, Jeferson dos Santos Souza, Juan Jose Moyano Muñoz, Jeyson Pereira da Silva, Ademar Lopes, Cristovam Scapulatempo-Neto, Eliney Ferreira Faria, Jean-Marie Delaissé, Fabio Albuquerque Marchi, Silvia Regina Rogatto
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Extracellular matrix (ECM) remodeling and inflammation have been reported in penile carcinomas (PeCa). However, the cell types and cellular crosstalk involved in PeCa are unexplored. We aimed to characterize the complexity of cells and pathways invol
Externí odkaz:
https://doaj.org/article/a2f43b984e634f36a7f7b6c88d6fea3b
Autor:
Qin Wu, Wail ba-alawi, Genevieve Deblois, Jennifer Cruickshank, Shili Duan, Evelyne Lima-Fernandes, Jillian Haight, Seyed Ali Madani Tonekaboni, Anne-Marie Fortier, Hellen Kuasne, Trevor D. McKee, Hassan Mahmoud, Michelle Kushida, Sarina Cameron, Nergiz Dogan-Artun, WenJun Chen, Yan Nie, Lan Xin Zhang, Ravi N. Vellanki, Stanley Zhou, Panagiotis Prinos, Bradly G. Wouters, Peter B. Dirks, Susan J. Done, Morag Park, David W. Cescon, Benjamin Haibe-Kains, Mathieu Lupien, Cheryl H. Arrowsmith
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level
Externí odkaz:
https://doaj.org/article/130018a3112a40a29ff505012c3352a4
Autor:
Erika Naakka, Mateus Camargo Barros-Filho, Shady Adnan-Awad, Ahmed Al-Samadi, Fábio Albuquerque Marchi, Hellen Kuasne, Katja Korelin, Ilida Suleymanova, Amy Louise Brown, Cristovam Scapulatempo-Neto, Silvia Vanessa Lourenço, Rogério Moraes Castilho, Luiz Paulo Kowalski, Antti Mäkitie, Vera Cavalcanti Araújo, Ilmo Leivo, Silvia Regina Rogatto, Tuula Salo, Fabricio Passador-Santos
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
ObjectivesTo integrate mRNA and miRNA expression profiles of mucoepidermoid carcinomas (MECs) and normal salivary gland (NSGs) tissue samples and identify potential drivers.Material and MethodsGene and miRNA expression arrays were performed in 35 MEC
Externí odkaz:
https://doaj.org/article/ad28b40ff1f040b1b06240343e6c9f9a
Autor:
Isabella Maria Dias Payão Ortiz, Mateus Camargo Barros-Filho, Mariana Bisarro dos Reis, Caroline Moraes Beltrami, Fabio Albuquerque Marchi, Hellen Kuasne, Luísa Matos do Canto, Julia Bette Homem de Mello, Cecilie Abildgaard, Clóvis Antônio Lopes Pinto, Luiz Paulo Kowalski, Silvia Regina Rogatto
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background DNA methylation in miRNA genes has been reported as a mechanism that may cause dysregulation of mature miRNAs and consequently impact the gene expression. This mechanism is largely unstudied in papillary thyroid carcinomas (PTC).
Externí odkaz:
https://doaj.org/article/a1e9f36f064e40fa86aa2ad50e93023e
Autor:
Paulo Roberto Stevanato Filho, Samuel Aguiar Júnior, Maria Dirlei Begnami, Hellen Kuasne, Ranyell Matheus Spencer, Wilson Toshihiko Nakagawa, Tiago Santoro Bezerra, Bruna Catin Kupper, Renata Maymi Takahashi, Mateus Barros Filho, Silvia Regina Rogatto, Ademar Lopes
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polypo
Externí odkaz:
https://doaj.org/article/9e572fb3a20a44bb9057cf0383982920
Autor:
Fabio Albuquerque Marchi, David Correa Martins, Mateus Camargo Barros-Filho, Hellen Kuasne, Ariane Fidelis Busso Lopes, Helena Brentani, Jose Carlos Souza Trindade Filho, Gustavo Cardoso Guimarães, Eliney F. Faria, Cristovam Scapulatempo-Neto, Ademar Lopes, Silvia Regina Rogatto
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Molecular data generation and their combination in penile carcinomas (PeCa), a significant public health problem in poor and underdeveloped countries, remain virtually unexplored. An integrativemethodology combin ing genome-wide copy number
Externí odkaz:
https://doaj.org/article/567d21a2e38742ad89f2318f9882dae3