Structural basis of mRNA decay by the human exosome-ribosome supercomplex.

Autor: Kögel A; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany., Keidel A; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany., Loukeri MJ; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany., Kuhn CC; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany., Langer LM; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany., Schäfer IB; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany. ischaefe@biochem.mpg.de.; Paul Langerhans Institute Dresden and Center of Membrane Biochemistry and Lipid Research, Faculty of Medicine, TU Dresden, Dresden, Germany. ischaefe@biochem.mpg.de.; German Center for Diabetes Research, Neuherberg, Germany. ischaefe@biochem.mpg.de., Conti E; Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried, Germany. conti@biochem.mpg.de.

Publikováno v: Nature [Nature] 2024 Nov; Vol. 635 (8037), pp. 237-242. Date of Electronic Publication: 2024 Oct 09.

Chemical and topological design of multicapped mRNA and capped circular RNA to augment translation.

Autor: Chen H; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Liu D; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aditham A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Guo J; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huang J; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kostas F; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Maher K; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, MA, USA., Friedrich MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA., Zhang F; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Cambridge, MA, USA.; McGovern Institute for Brain Research at MIT, Cambridge, MA, USA.; Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Wang X; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA. xwangx@mit.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. xwangx@mit.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. xwangx@mit.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 Sep 23. Date of Electronic Publication: 2024 Sep 23.

OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress.

Autor: Villa S; Quantitative and Systems Biology, University of California, Merced, CA, 95343, USA.; Calico Life Sciences, 1170 Veterans Boulevard, South San Francisco, CA, 94080, USA., Dwivedi P; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.; Merck, West Point, PA, 19486, USA., Stahl A; Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, 52242, USA.; Department of Neuroscience, Scripps Research, Jupiter, FL, 33458, USA., Hinkle T; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Rose CM; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Kirkpatrick DS; Department of Microchemistry, Proteomics, and Lipidomics, Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA.; Xaira Therapeutics, Brisbane, CA, 94005, USA., Tomchik SM; Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, 52242, USA.; Department of Neuroscience, Scripps Research, Jupiter, FL, 33458, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, 52242, USA.; Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA, 52242, USA., Dixit VM; Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA., Wolf FW; Quantitative and Systems Biology, University of California, Merced, CA, 95343, USA. fwolf@ucmerced.edu.; Department of Molecular and Cell Biology, University of California, Merced, CA, 95343, USA. fwolf@ucmerced.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 11; Vol. 15 (1), pp. 6873. Date of Electronic Publication: 2024 Aug 11.

Sex chromosome-encoded protein homologs: current progress and open questions.

Autor: Owens MC; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.; Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, USA., Yanas A; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.; Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, USA., Liu KF; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. liufg@pennmedicine.upenn.edu.; Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, USA. liufg@pennmedicine.upenn.edu.; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA, USA. liufg@pennmedicine.upenn.edu.; Penn Center for Genome Integrity, University of Pennsylvania, Philadelphia, PA, USA. liufg@pennmedicine.upenn.edu.

Publikováno v: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Aug; Vol. 31 (8), pp. 1156-1166. Date of Electronic Publication: 2024 Aug 09.

Diversity of Picorna-Like Viruses in the Teltow Canal, Berlin, Germany.

Autor: Zell, Roland¹ (AUTHOR) roland.zell@med.uni-jena.de, Groth, Marco² (AUTHOR), Selinka, Lukas¹ (AUTHOR), Selinka, Hans-Christoph³ (AUTHOR)

Publikováno v: Viruses (1999-4915). Jul2024, Vol. 16 Issue 7, p1020. 19p.