Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Helleboid-Chapman A"'
Autor:
Ploton, Maheul, Mazuy, Claire, Gheeraert, Céline, Dubois, Vanessa, Berthier, Alexandre, Dubois-Chevalier, Julie, Maréchal, Xavier, Bantubungi, Kadiombo, Diemer, Hélène, Cianférani, Sarah, Strub, Jean-Marc, Helleboid-Chapman, Audrey, Eeckhoute, Jérôme, Staels, Bart, Lefebvre, Philippe
Publikováno v:
In Journal of Hepatology November 2018 69(5):1099-1109
Publikováno v:
Journal of Hepatology
Autor:
Maheul Ploton, Wahiba Berrabah, Bart Staels, Philippe Lefebvre, Claire Mazuy, Jérôme Eeckhoute, Audrey Helleboid-Chapman
Publikováno v:
FEBS Letters. 587:3883-3890
Nur77 is a stress sensor in pancreatic β-cells, which negatively regulates glucose-stimulated insulin secretion. We recently showed that a lipotoxic shock caused by exposure of β-cells to the saturated fatty acid palmitate strongly increases Nur77
Autor:
Emmanuelle Moitrot, Audrey Helleboid-Chapman, Jamila Fruchart-Najib, Heidelinde Jakel, Len A. Pennacchio, Corinne Rommens, Jean-Charles Fruchart, Maxime Nowak
Publikováno v:
Journal of Molecular Biology. 380:789-798
The apolipoprotein A5 gene (APOA5) is a key player in determining triglyceride concentrations in humans and mice. Since diabetes is often associated with hypertriglyceridemia, this study explores whether APOA5 gene expression is regulated by alterati
Autor:
Maxime Nowak, Jean-Charles Fruchart, Heidelinde Jakel, Audrey Helleboid-Chapman, Jamila Fruchart-Najib
Publikováno v:
Annals of Medicine. 38:2-10
Hypertriglyceridemia is an independent risk factor for the development of cardiovascular disease and is often associated with diabetes, inflammation and the metabolic syndrome. Recently, apolipoprotein A5 (APOA5) was identified as a novel member of t
Autor:
Bart Staels, Audrey Helleboid-Chapman, Len A. Pennacchio, Hélène Dehondt, Jean-Charles Fruchart, Annelise Genoux, Geneviève Martin, Jamila Fruchart-Najib, Christian Duhem, Dean W. Hum
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:1186-1192
Objective— The newly identified apolipoprotein A5 ( APOA5 ), selectively expressed in the liver, is a crucial determinant of plasma triglyceride levels. Because elevated plasma triglyceride concentrations constitute an independent risk factor for c
Autor:
Maxime Nowak, Heidelinde Jakel, Len A. Pennacchio, Daniel Duran-Sandoval, Jean-Charles Fruchart, Audrey Helleboid-Chapman, Bart Staels, Edward M. Rubin, Jamila Fruchart-Najib, Geneviève Martin, Marja-Riitta Taskinen
Publikováno v:
Molecular and Cellular Biology. 25:1537-1548
The apolipoprotein A5 gene (APOA5) has been repeatedly implicated in lowering plasma triglyceride levels. Since several studies have demonstrated that hyperinsulinemia is associated with hypertriglyceridemia, we sought to determine whether APOA5 is r
Autor:
Rodolphe Carpentier, Brigitte Vandewalle, Audrey Helleboid-Chapman, François Pattou, Philippe Lefebvre, Nathalie Hennuyer, Olivier Briand, Valery Gmyr, Bart Staels, Julie Kerr-Conte, Maheul Ploton, Ericka Moerman, Jérôme Eeckhoute
The NR4A orphan nuclear receptors Nur77, Nurr1, and Nor1 exert multiple cellular and metabolic functions. These transcriptional regulators are activated in response to extracellular stresses, including lipotoxic fatty acids (FA) and proinflammatory c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdba7897267a88a57ab97d273a38557
https://europepmc.org/articles/PMC5417130/
https://europepmc.org/articles/PMC5417130/
Autor:
François Pattou, Iuliana Popescu, Julie Kerr-Conte, Anthony Lucas, Sandrine Caron, Emmanuel Bouchaert, Audrey Helleboid-Chapman, Bart Staels, Julie Dumont, Bruno Derudas, Brigitte Vandewalle
Publikováno v:
FEBS Letters
FEBS Letters, 2010, 584 (13), pp.2845-51. ⟨10.1016/j.febslet.2010.04.068⟩
FEBS Letters, Wiley, 2010, 584 (13), pp.2845-51. ⟨10.1016/j.febslet.2010.04.068⟩
FEBS Letters, 2010, 584 (13), pp.2845-51. ⟨10.1016/j.febslet.2010.04.068⟩
FEBS Letters, Wiley, 2010, 584 (13), pp.2845-51. ⟨10.1016/j.febslet.2010.04.068⟩
International audience; Farnesoid X receptor (FXR) is highly expressed in liver and intestine where it controls bile acid (BA), lipid and glucose homeostasis. Here we show that FXR is expressed and functional, as assessed by target gene expression an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870ad5fb5581e103c1c3b5926e7545c0
https://www.hal.inserm.fr/inserm-00485665/file/Art_RISTEA.pdf
https://www.hal.inserm.fr/inserm-00485665/file/Art_RISTEA.pdf
Autor:
Stéphane Helleboid, Hélène Dehondt, Emmanuelle Moitrot, Hervé Drobecq, Jean-Charles Fruchart, Corinne Rommens, Jamila Fruchart-Najib, Maxime Nowak, Audrey Helleboid-Chapman, Laurent Héliot
Publikováno v:
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 24(5-6)
Apolipoprotein A-V is an important determinant of plasma triglyceride level in both humans and mice. This study showed the physiological impact of apoA-V on insulin secretion in rat pancreatic beta-cells (INS-1 cells). In order to precise the mechani