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of 7
pro vyhledávání: '"Helle Lynggaard"'
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-4 (2023)
Abstract Background The estimand for a clinical trial is a precise definition of the treatment effect to be estimated. Traditionally, estimates of treatment effects are based on either an ITT analysis or a per-protocol analysis. However, there are im
Externí odkaz:
https://doaj.org/article/f79c9f497f0b4bdf8973281120c9ba57
Autor:
Helle Lynggaard, James Bell, Christian Lösch, Amel Besseghir, Khadija Rantell, Volker Schoder, Vivian Lanius
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Clinical study protocols are the foundation of good clinical studies. Prospective and multidisciplinary collaboration that pays attention to the design of all components of the study protocol can ensure that a clinical study will answer the
Externí odkaz:
https://doaj.org/article/5bcd4a8937fe437cb3502ec61c52e7a2
Publikováno v:
Gao, Y, Luquez, C, Lynggaard, H, Andersen, H & Saboo, B 2014, ' The SimpleMix study with biphasic insulin aspart 30 : a randomized controlled trial investigating patient-driven titration versus investigator-driven titration ', Current Medical Research and Opinion, vol. 30, no. 12, pp. 2483-92 . https://doi.org/10.1185/03007995.2014.960512
OBJECTIVE: The study aimed to confirm the efficacy, through non-inferiority, of patient-driven versus investigator-driven titration of biphasic insulin aspart 30 (BIAsp 30) in terms of glycemic control assessed by HbA1c change.METHODS: SimpleMix was
Autor:
Francesco Chiarelli, Nobuo Matsuura, Pedro Martul, Stephen Greene, Jan Åman, Peter G.F. Swift, Dennis Daneman, Hannah McGee, Eugen J. Schoenle, Oddmund Søvik, Maurizio Vanelli, Rosa Maria Tsou, Kenneth Robertson, Henk-Jan Aanstoot, Patrick Garandeau, Eero A. Kaprio, Soren E. Skovlund, Philip Hougaard, Michael Fitzgerald, Harry Dorchy, Helle Lynggaard, Mirjana Kocova, Thomas Danne, Henrik B. Mortensen, Reinhard W. Holl, Hilary Hoey
Publikováno v:
Hoey, H, McGee, H M, Fitzgerald, M, Mortensen, H B, Hougaard, P, Lynggaard, H, Skovlund, S E, Aanstoot, H-J, Chiarelli, F, Daneman, D, Danne, T, Dorchy, H, Garandeau, P, Greene, S, Holl, R, Kaprio, E, Kocova, M, Martul, P, Matsuura, N, Robertson, K, Schoenle, E, Sovik, O, Swift, P, Tsou, R M, Vanelli, M, Aman, J & Hvidøre Study Group on Childhood Diabetes 2006, ' Parent and health professional perspectives in the management of adolescents with diabetes : development of assessment instruments for international studies ', Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, vol. 15, no. 6, pp. 1033-42 . https://doi.org/10.1007/s11136-006-0042-8
OBJECTIVE: Assessment of quality of life (QOL) in adolescents with diabetes requires patient, parent and health professional input. Psychometrically robust instruments to assess parent and professional perspectives are required.RESEARCH DESIGN AND ME
Autor:
Eero A. Kaprio, Denis Daneman, Patrick Garandeau, Peter G.F. Swift, Oddmund Søvik, Pedro Martul, Hilary Hoey, Mirjana Kocova, Maurizio Vanelli, Kenneth Robertson, Nobuo Matsuura, Francesco Chiarelli, Eugen J. Schoenle, Jan Åman, Henk-Jan Aanstoot, Steven Greene, Rosa-Maria Tsou, Harry Dorchy, Helle Lynggaard, Reinhard W. Holl, Phillip Hougaard, Thomas Danne, Henrik B. Mortensen
Publikováno v:
European Journal of Pediatrics. 162:22-29
The optimal insulin regimen for paediatric patients with type 1 diabetes remains controversial. Therefore this multicentre study was performed in adolescents over a 3-year period to assess metabolic control, severe hypoglycaemia, and weight gain in r
Autor:
Henk-Jan Aanstoot, Patrick Garandeau, Mirjana Kocova, Hannah McGee, Nobuo Matsuura, Oddmund Søvik, Denis Daneman, Hilary Hoey, Jan Åman, Philip Hougaard, Peter G.F. Swift, Pedro Martul, Stephen Greene, Michael Fitzgerald, Reinhard W. Holl, Eugen J. Schoenle, Eero A. Kaprio, Thomas Danne, Rosa Maria Tsou, Helle Lynggaard, Henrik B. Mortensen, Harry Dorchy, Kenneth Robertson, Francesco Chiarelli, Maurizio Vanelli
Publikováno v:
Diabetes Care. 24:1923-1928
OBJECTIVE—It is unclear whether the demands of good metabolic control or the consequences of poor control have a greater influence on quality of life (QOL) for adolescents with diabetes. This study aimed to assess these relations in a large interna
Autor:
Jan Åman, Kenneth Robertson, Maurizio Vanelli, Stephen Greene, Oddmund Søvik, Patrick Garandeau, Henk-Jan Aanstoot, Mirjana Kocova, Reinhard W. Holl, Nobuo Matsuura, Thomas Danne, Hilary Hoey, Henrik B. Mortensen, Philip Hougaard, Eugen J. Schoenle, Francesco Chiarelli, Rosa Maria Tsou, Pedro Martul, Eero A. Kaprio, Peter G.F. Swift, Denis Daneman, Harry Dorchy, Helle Lynggaard
Publikováno v:
Diabetes Care. 24:1342-1347
OBJECTIVE—Twenty-one international pediatric diabetes centers from 17 countries investigated the effect of simple feedback about the grand mean HbA1c level of all centers and the average value of each center on changes in metabolic control, rate of