Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Helle H Nielsen"'
Publikováno v:
Brain Sciences, Vol 11, Iss 1, p 38 (2021)
The use of non-selective tumor necrosis factor (TNF) inhibitors is well known in the treatment of inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, and psoriasis. Its use in neurological disorders is limited however, due to rare
Externí odkaz:
https://doaj.org/article/a80263f769f543b39283051b946bf756
Autor:
Nellie A Martin, Arkadiusz Nawrocki, Viktor Molnar, Maria L Elkjaer, Eva K Thygesen, Miklos Palkovits, Peter Acs, Tobias Sejbaek, Helle H Nielsen, Zoltan Hegedus, Finn Sellebjerg, Tihamer Molnar, Eudes G V Barbosa, Nicolas Alcaraz, Ferenc Gallyas, Asa F Svenningsen, Jan Baumbach, Hans Lassmann, Martin R Larsen, Zsolt Illes
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202530 (2018)
OBJECTIVE:Here, we applied a multi-omics approach (i) to examine molecular pathways related to de- and remyelination in multiple sclerosis (MS) lesions; and (ii) to translate these findings to the CSF proteome in order to identify molecules that are
Externí odkaz:
https://doaj.org/article/f5ed24cb4fb74452b64b252b86d998fc
Autor:
Helle H Nielsen, Hans C Beck, Lars P Kristensen, Mark Burton, Tunde Csepany, Magdolna Simo, Peter Dioszeghy, Tobias Sejbaek, Manuela Grebing, Niels H H Heegaard, Zsolt Illes
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139659 (2015)
Inflammatory demyelinating diseases of the CNS comprise a broad spectrum of diseases like neuromyelitis optica (NMO), NMO spectrum disorders (NMO-SD) and multiple sclerosis (MS). Despite clear classification criteria, differentiation can be difficult
Externí odkaz:
https://doaj.org/article/0de9f23466e84c92a8c90d2a1defe7d5
Autor:
Helle H. Nielsen, Catarina B. Soares, Sofie S. Høgedal, Jonna S. Madsen, Rikke B. Hansen, Alex A. Christensen, Charlotte Madsen, Bettina H. Clausen, Lars Henrik Frich, Matilda Degn, Christian Sibbersen, Kate L. Lambertsen
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Ischemic stroke causes increased blood–brain barrier permeability and release of markers of axonal damage and inflammation. To investigate diagnostic and prognostic roles of neurofilament light chain (NF-L), we assessed levels of NF-L,
Externí odkaz:
https://doaj.org/article/80ab9067054241c3bf407ae0d6aabc2d
Autor:
Birgitte Villadsen, Camilla Thygesen, Manuela Grebing, Stefan J. Kempf, Marie B. Sandberg, Pia Jensen, Stefanie H. Kolstrup, Helle H. Nielsen, Martin R. Larsen, Bente Finsen
Publikováno v:
Journal of neurochemistry.
Ceruloplasmin (Cp) is a multicopper oxidase with ferroxidase properties being of importance to the mobilisation and export of iron from cells and its ability to bind copper. In aging humans, Cp deficiency is known to result in aceruloplasminemia, whi
Publikováno v:
Brain Sciences, Vol 10, Iss 1, p 56 (2020)
Neurofilaments (NFs) are quickly becoming the biomarkers of choice in the field of neurology, suggesting their use as an unspecific screening marker, much like the use of elevated plasma C-reactive protein (CRP) in other fields. With sensitive techni
Externí odkaz:
https://doaj.org/article/2dff7936561d450fab951998882cc958
Autor:
Cecilie Dollerup Skov, Christina Borgen Sørensen, Maria Thorning, Kate Lykke Lambertsen, Lars Henrik Frich, Henrik Boye Jensen, Anders Holsgaard-Larsen, Helle H Nielsen
Publikováno v:
Multiple sclerosis and related disorders. 66
The purpose of this interventional study on participants with multiple sclerosis (MS) with walking disability was to evaluate changes in functional hand and walking measurements after fampridine treatment, after stratifying by the Expanded Disability
Autor:
Keld-Erik Byg, Zsolt Illes, Tobias Sejbaek, Nina Nguyen, Sören Möller, Kate L. Lambertsen, Helle H. Nielsen, Torkell Ellingsen
Publikováno v:
Journal of Neuroimmunology. 369:577913
Twenty patients with newly diagnosed neurosarcoidosis were examined for multiple outcomes in an observational cohort study with 12-month follow-up.The patients' contrast-enhancing lesions on MRI scans reduced during treatment (p 0.0001). The mean mod
Autor:
Keld-Erik Byg, Zsolt Illes, Tobias Sejbaek, Kate L. Lambertsen, Torkell Ellingsen, Helle H. Nielsen
Publikováno v:
Byg, K-E, Illés, Z, Sejbæk, T, Lambertsen, K L, Ellingsen, T J & Nielsen, H H 2022, ' Inflammatory profiles in plasma and cerebrospinal fluid of patients with neurosarcoidosis ', Journal of Neuroimmunology, vol. 367, 577849 . https://doi.org/10.1016/j.jneuroim.2022.577849
Methods: Cerebrospinal fluid (CSF) and plasma levels of 38 biomarkers from 20 neurosarcoidosis (NS) patients were compared to healthy controls (HC). Results: In CSF, 25 biomarkers were significantly elevated compared to HC: IFNγ, TNFα, TNFβ, IL-2,
Autor:
Barbara Uzonyi, Zsóka Szabó, Eszter Trojnár, Satu Hyvärinen, Katalin Uray, Helle H. Nielsen, Anna Erdei, T. Sakari Jokiranta, Zoltán Prohászka, Zsolt Illes, Mihály Józsi
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Uzonyi, B, Szabó, Z, Trojnár, E, Hyvärinen, S, Uray, K, Nielsen, H H, Erdei, A, Jokiranta, T S, Prohászka, Z, Illes, Z & Józsi, M 2021, ' Autoantibodies Against the Complement Regulator Factor H in the Serum of Patients With Neuromyelitis Optica Spectrum Disorder ', Frontiers in Immunology, vol. 12, 660382 . https://doi.org/10.3389/fimmu.2021.660382
Frontiers in Immunology, Vol 12 (2021)
Uzonyi, B, Szabó, Z, Trojnár, E, Hyvärinen, S, Uray, K, Nielsen, H H, Erdei, A, Jokiranta, T S, Prohászka, Z, Illes, Z & Józsi, M 2021, ' Autoantibodies Against the Complement Regulator Factor H in the Serum of Patients With Neuromyelitis Optica Spectrum Disorder ', Frontiers in Immunology, vol. 12, 660382 . https://doi.org/10.3389/fimmu.2021.660382
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS), characterized by pathogenic, complement-activating autoantibodies against the main water channel in the CNS, aquaporin 4 (AQP4).