Selenoprotein deficiency disorder predisposes to aortic aneurysm formation

Autor: Erik Schoenmakers, Federica Marelli, Helle F. Jørgensen, W. Edward Visser, Carla Moran, Stefan Groeneweg, Carolina Avalos, Sean J. Jurgens, Nichola Figg, Alison Finigan, Neha Wali, Maura Agostini, Hannah Wardle-Jones, Greta Lyons, Rosemary Rusk, Deepa Gopalan, Philip Twiss, Jacob J. Visser, Martin Goddard, Samer A. M. Nashef, Robin Heijmen, Paul Clift, Sanjay Sinha, James P. Pirruccello, Patrick T. Ellinor, Elisabeth M. Busch-Nentwich, Ramiro Ramirez-Solis, Michael P. Murphy, Luca Persani, Martin Bennett, Krishna Chatterjee

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Aortic aneurysms, which may dissect or rupture acutely and be lethal, can be a part of multisystem disorders that have a heritable basis. We report four patients with deficiency of selenocysteine-containing proteins due to selenocysteine Ins

Externí odkaz: https://doaj.org/article/9890b834ab67406cacc92d0ad7bdebb8

Somatostatin Receptor PET/MR Imaging of Inflammation in Patients With Large Vessel Vasculitis and Atherosclerosis

Autor: Andrej Ćorović, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jørgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H.F. Rudd, Justin C. Mason, Jason M. Tarkin

Publikováno v: Ćorović, A, Wall, C, Nus, M, Gopalan, D, Huang, Y, Imaz, M, Zulcinski, M, Peverelli, M, Uryga, A, Lambert, J, Bressan, D, Maughan, R T, Pericleous, C, Dubash, S, Jordan, N, Jayne, D R, Hoole, S P, Calvert, P A, Dean, A F, Rassl, D, Barwick, T, Iles, M, Frontini, M, Hannon, G, Manavaki, R, Fryer, T D, Aloj, L, Graves, M J, Gilbert, F J, Dweck, M R, Newby, D E, Fayad, Z A, Reynolds, G, Morgan, A W, Aboagye, E O, Davenport, A P, Jørgensen, H F, Mallat, Z, Bennett, M R, Peters, J E, Rudd, J H F, Mason, J C & Tarkin, J M 2023, ' Somatostatin Receptor PET/MR Imaging of Inflammation in Patients with Large Vessel Vasculitis and Atherosclerosis ', Journal of the American College of Cardiology, vol. 81, no. 4, pp. 336-354 . https://doi.org/10.1016/j.jacc.2022.10.034, https://doi.org/10.1016/j.jacc.2022.10.034

Background:Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be challenging by conventional measures. Objectives:We aimed to investigate somatostatin receptor 2 (SST2) as a novel inflammation-specific molecular imaging targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160dc50b6bb26e3f1bcc28ffe5e6ba6c
https://zenodo.org/record/7912981

DNA glycosylase Neil3 regulates vascular smooth muscle cell biology during atherosclerosis development

Autor: Magnar Bjørås, Pål Aukrust, Bente Halvorsen, Jonas Øgaard, Erik A.L. Biessen, Filip M. Segers, Martin R. Bennett, Eric P. van der Veer, Helle F. Jørgensen, Katja Scheffler, Ellen Lund Sagen, Sverre Holm, Ståle Nygård, Vigdis Bjerkeli, Kirsten B. Holven, Jurriën Prins, Tuula A. Nyman, Xiang Yi Kong, Knut H. Lauritzen, Tuva B. Dahl, Hilde Nilsen, Tom Rune Karlsen, Kuan Yang, Ana Quiles-Jiménez, Penelope Kroustallaki, Yngvar Fløisand, Maria Belland Olsen, Tonje Skarpengland, Rajikala Suganthan, Ida Gregersen

Publikováno v: Atherosclerosis, 324, 123-132. Elsevier Ireland Ltd
Atherosclerosis

Background and aims: Atherogenesis involves a complex interaction between immune cells and lipids, processes greatly influenced by the vascular smooth muscle cell (VSMC) phenotype. The DNA glycosylase NEIL3 has previously been shown to have a role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b3cb8f608b1a6a650ba77f96dfd8d5
https://doi.org/10.1016/j.atherosclerosis.2021.02.023

BS34 Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury

Autor: Abel Martin Garrido, Fabrizio d'Adda di Fagagna, Kirsty Foote, Anna K. Uryga, Helle F. Jørgensen, Martin R. Bennett, Joel Chappell, Francesca Rossiello, Dimitra Aravani, Mandy O.J. Grootaert, Alison Finigan, Sebnem Oc

Publikováno v: Basic science.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c1c70a216745e3c8ffbb8575ff703ae
https://doi.org/10.1136/heartjnl-2021-bcs.232

Vascular Smooth Muscle Cell Plasticity and Autophagy in Dissecting Aortic Aneurysms

Autor: Juliette Raffort, Annabel L. Taylor, Patrick Bruneval, Helle F. Jørgensen, Alison Finigan, Martin R. Bennett, James Harrison, Ziad Mallat, Marc Clement, Fabien Lareyre, Joel Chappell, Soraya Taleb, Marie Vandestienne

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 39:1149-1159

Objective— Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However, lineage-tracing studies are still lacking, and the behavior of VSMCs during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec8da7b89c087144fe542037e453a669
https://doi.org/10.1161/atvbaha.118.311727