Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Helle D. Ulrich"'
Autor:
Lonnie P. Swift, B. Christoffer Lagerholm, Lucy R. Henderson, Malitha Ratnaweera, Hannah T. Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D. Ulrich, Joseph A. Newman, Christopher J. Schofield, Peter J. McHugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to comple
Externí odkaz:
https://doaj.org/article/cd10c307980d47f8a16e6289838eff95
Autor:
Kook Son, Vakil Takhaveev, Visesato Mor, Hobin Yu, Emma Dillier, Nicola Zilio, Nikolai J. L. Püllen, Dmitri Ivanov, Helle D. Ulrich, Shana J. Sturla, Orlando D. Schärer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Most genotoxic anticancer agents fail in tumors with intact DNA repair. Therefore, trabectedin, anagent more toxic to cells with active DNA repair, specifically transcription-coupled nucleotide excision repair (TC-NER), provides therapeutic
Externí odkaz:
https://doaj.org/article/1a45c02a032c494596a84c053a37fd46
Autor:
Jie Shi, Kristine Hauschulte, Ivan Mikicic, Srijana Maharjan, Valerie Arz, Tina Strauch, Jan B. Heidelberger, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Petra Beli, Helle D. Ulrich, Hans-Peter Wollscheid
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The actin cytoskeleton is of fundamental importance for cellular structure and plasticity. However, abundance and function of filamentous actin in the nucleus are still controversial. Here we show that the actin-based molecular motor myosin
Externí odkaz:
https://doaj.org/article/664388851c7f4b1e93e0bfdb9d7cdc53
Autor:
Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D. Ulrich, Dennis Kappei, René F. Ketting, Falk Butter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Telomeres, tandem repeats at the ends of linear chromosomes, have evolved to deal with the end replication and end protection. Using a proteomics approach, the authors identify TEBP-1 and TEBP-2, two double-stranded binding proteins which together ar
Externí odkaz:
https://doaj.org/article/f83ddf084bc149738d2f2680d08fdb42
Autor:
Annie M. Sriramachandran, Katrin Meyer-Teschendorf, Stefan Pabst, Helle D. Ulrich, Niels H. Gehring, Kay Hofmann, Gerrit J. K. Praefcke, R. Jürgen Dohmen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The cellular functions of poly-SUMO chains of different compositions are not fully understood. Here, the authors characterize Arkadia/RNF111 as a SUMO-targeted ubiquitin ligase that recognizes proteins with hybrid SUMO1-capped SUMO2/3 chains and targ
Externí odkaz:
https://doaj.org/article/d0762ab2824541ce8ce0b7085be1b113
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100076- (2020)
Summary: GLOE-Seq is a next-generation sequencing method for the genome-wide mapping of 3′-OH termini, either resulting from single- or double-strand breaks or introduced by enzymatic conversion of lesions or modified nucleotides. This protocol pro
Externí odkaz:
https://doaj.org/article/271be5ee97a1498598352e58f80f9bb0
Autor:
Arianna Lockhart, Vanessa Borges Pires, Fabio Bento, Vanessa Kellner, Sarah Luke-Glaser, George Yakoub, Helle D. Ulrich, Brian Luke
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2890-2900.e5 (2019)
Summary: RNA-DNA hybrids are tightly regulated to ensure genome integrity. The RNase H enzymes RNase H1 and H2 contribute to chromosomal stability through the removal of RNA-DNA hybrids. Loss of RNase H2 function is implicated in human diseases of th
Externí odkaz:
https://doaj.org/article/a5ec3288a6eb4673abec1547d2f32951
Autor:
Christian Renz, Evrydiki Asimaki, Cindy Meister, Véronique Albanèse, Kirill Petriukov, Nils Krapoth, Sabrina Wegmann, Hans-Peter Wollscheid, Ronald Wong, Sébastien Léon, Helle D. Ulrich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8096be60e96bbc6014ddc8057b3e14eb
https://doi.org/10.2139/ssrn.4421571
https://doi.org/10.2139/ssrn.4421571
Autor:
James A. Oo, Katalin Pálfi, Timothy Warwick, Ilka Wittig, Cristian Prieto-Garcia, Vigor Matkovic, Ines Tomašković, Frederike Boos, Judit Izquierdo Ponce, Tom Teichmann, Kirill Petriukov, Shaza Haydar, Lars Maegdefessel, Zhiyuan Wu, Minh Duc Pham, Jaya Krishnan, Andrew H. Baker, Stefan Günther, Helle D. Ulrich, Ivan Dikic, Matthias S. Leisegang, Ralf P. Brandes
Publikováno v:
Cell Reports, 41(7):111670. Cell Press
Cell Reports: Methods
Cell Reports: Methods
In healthy vessels, endothelial cells maintain a stable, differentiated, and growth-arrested phenotype for years. Upon injury, a rapid phenotypic switch facilitates proliferation to restore tissue perfusion. Here we report the identification of the e
Autor:
Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36cf4ac37486df5deea1fc767a563a32
https://doi.org/10.7554/elife.79676.sa2
https://doi.org/10.7554/elife.79676.sa2