Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Helle Bogetofte"'
Autor:
Helle Bogetofte, Brent J. Ryan, Pia Jensen, Sissel I. Schmidt, Dana L.E. Vergoossen, Mike B. Barnkob, Lisa N. Kiani, Uroosa Chughtai, Rachel Heon-Roberts, Maria Claudia Caiazza, William McGuinness, Ricardo Márquez-Gómez, Jane Vowles, Fiona S. Bunn, Janine Brandes, Peter Kilfeather, Jack P. Connor, Hugo J.R. Fernandes, Tara M. Caffrey, Morten Meyer, Sally A. Cowley, Martin R. Larsen, Richard Wade-Martins
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112180- (2023)
Summary: Variants at the GBA locus, encoding glucocerebrosidase, are the strongest common genetic risk factor for Parkinson’s disease (PD). To understand GBA-related disease mechanisms, we use a multi-part-enrichment proteomics and post-translation
Externí odkaz:
https://doaj.org/article/82feb45f7a544f64addd016b4fe4a636
Autor:
Helle Bogetofte, Pia Jensen, Justyna Okarmus, Sissel Ida Schmidt, Mikkel Agger, Matias Ryding, Peter Nørregaard, Christina Fenger, Xianmin Zeng, Jesper Graakjær, Brent James Ryan, Richard Wade-Martins, Martin Røssel Larsen, Morten Meyer
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
Mutations in parkin, encoded by the PARK2 gene, causes early-onset familial Parkinson's disease (PD), but dysfunctional parkin has also been implicated in sporadic PD. By combining human isogenic induced pluripotent stem cells (iPSCs) with and withou
Externí odkaz:
https://doaj.org/article/e98e9afd23534172af5a503933362700
Autor:
Helle Bogetofte, Pia Jensen, Matias Ryding, Sissel I. Schmidt, Justyna Okarmus, Louise Ritter, Christina S. Worm, Michaela C. Hohnholt, Carla Azevedo, Laurent Roybon, Lasse K. Bak, Helle Waagepetersen, Brent J. Ryan, Richard Wade-Martins, Martin R. Larsen, Morten Meyer
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to inv
Externí odkaz:
https://doaj.org/article/76001a3b4cfe44f1a503e596795f8bcb
Autor:
Hugo J.R. Fernandes, Elizabeth M. Hartfield, Helen C. Christian, Evangelia Emmanoulidou, Ying Zheng, Heather Booth, Helle Bogetofte, Charmaine Lang, Brent J. Ryan, S. Pablo Sardi, Jennifer Badger, Jane Vowles, Samuel Evetts, George K. Tofaris, Kostas Vekrellis, Kevin Talbot, Michele T. Hu, William James, Sally A. Cowley, Richard Wade-Martins
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 342-356 (2016)
Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest common genetic risk factor for Parkinson's disease (PD), the second most common neurodegenerative disorder. However, the molecular mechanisms underlying this associat
Externí odkaz:
https://doaj.org/article/20acb6da0a224454831f8f80ba1147cd
Autor:
Anusha B. Gopalan, Lisa van Uden, Richard Sprenger, Nadine Fernandez-Novel Marx, Helle Bogetofte, Pierre A Neveu, Morten Meyer, Kyung Min Noh, Alba Diz-Munoz, Christer S. Ejsing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3e2ef373620611575231b7069f3f02
https://doi.org/10.15252/rc.2022337090
https://doi.org/10.15252/rc.2022337090
Autor:
Anusha B. Gopalan, Lisa van Uden, Richard R. Sprenger, Nadine Fernandez-Novel Marx, Helle Bogetofte, Pierre Neveu, Morten Meyer, Kyung-Min Noh, Alba Diz-Muñoz, Christer S. Ejsing
During development, different tissues acquire distinct lipotypes that are coupled to tissue function and homeostasis. In the brain, where complex membrane trafficking systems are required for neural function, specific glycerophospholipids, sphingolip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::388b80433338e114fa435064f9718c6a
https://doi.org/10.1101/2022.08.31.505694
https://doi.org/10.1101/2022.08.31.505694
Publikováno v:
Bogetofte, H, Alamyar, A, Blaabjerg, M & Meyer, M 2020, ' Levodopa therapy for Parkinson's disease : history, current status and perspectives ', C N S & Neurological Disorders-Drug Targets, vol. 19, no. 8, pp. 572-583 . https://doi.org/10.2174/1871527319666200722153156
Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by a preferential degeneration of dopaminergic neurons in the substantia nigra pars compacta. This results in a profound decrease of striatal dopamine (DA) levels, which in turn
Autor:
Luis A. García Rodríguez, Maria Therese Schelde-Olesen, Mette Hasle, Rustam Al-Shahi Salman, Jesper Hallas, Willy Krone, Christine Kring Sloth, Ida Christine Olesrud, David Gaist, Charlotte Madsen, Helle Bogetofte, Stefanie Binzer, Stine Munk Hald, Miriam Højholt, Mikkel Agger
Publikováno v:
Clinical Epidemiology. 12:1313-1325
Purpose To establish the validity of intracerebral hemorrhage (ICH) diagnoses in the Danish Stroke Registry (DSR) and the Danish National Patient Registry (DNPR). Patients and Methods Based on discharge summaries and brain imaging reports, we estimat
Autor:
Brent J. Ryan, Fernandes Hj, Bunn F, Martin R. Larsen, Pia Jensen, Kilfeather P, Richard Wade-Martins, Jane Vowles, Mike Bogetofte Barnkob, Helle Bogetofte, Vergoossen Dl, Chughtai U, Brandes J, Tara M. Caffrey, Kiani L, Morten Meyer, Sally A. Cowley
The causes of Parkinson’s disease (PD) likely involve complex interactions between environmental factors and susceptibility genes with variants at theGBAlocus encoding the glucocerebrosidase (GCase) enzyme being the strongest common genetic risk fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::668f36110dc40173e49a3f4fa50e835d
https://doi.org/10.1101/2021.06.30.450333
https://doi.org/10.1101/2021.06.30.450333
Autor:
Sissel Ida Schmidt, Alberto Martínez-Serrano, Brent J. Ryan, Justyna Okarmus, Helle Bogetofte, Poul Hyttel, Morten Meyer, Matias Ryding, Silvia García-López
Publikováno v:
Scientific Reports
Okarmus, J, Bogetofte, H, Schmidt, S I, Ryding, M, García-López, S, Ryan, B J, Martínez-Serrano, A, Hyttel, P & Meyer, M 2020, ' Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation ', Scientific Reports, vol. 10, 10278 . https://doi.org/10.1038/s41598-020-67091-6
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Okarmus, J, Bogetofte, H, Schmidt, S I, Ryding, M, García-López, S, Ryan, B J, Martínez-Serrano, A, Hyttel, P & Meyer, M 2020, ' Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation ', Scientific Reports, vol. 10, 10278 . https://doi.org/10.1038/s41598-020-67091-6
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd5b25f7e042edf0f1ac3e6d8ea98f8
https://ora.ox.ac.uk/objects/uuid:dcd9c4e9-8459-438e-9d9b-2afb48b4266d
https://ora.ox.ac.uk/objects/uuid:dcd9c4e9-8459-438e-9d9b-2afb48b4266d