Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Helle A. Praetorius"'
Autor:
Steen K. Fagerberg, Parth Patel, Lars W. Andersen, Xiaowen Lui, Michael W. Donnino, Helle A. Praetorius
Publikováno v:
Critical Care, Vol 22, Iss 1, Pp 1-12 (2018)
Abstract Background Pore-forming proteins released from bacteria or formed as result of complement activation are known to produce severe cell damage. Inhibition of purinergic P2X receptors markedly reduces damage inflicted by cytolytic bacterial tox
Externí odkaz:
https://doaj.org/article/c082b9be2cd548f2899b2f38d50c9d10
Publikováno v:
Toxins, Vol 5, Iss 3, Pp 472-487 (2013)
The pore-forming exotoxin α-hemolysin from E. coli causes a significant volume reduction of human erythrocytes that precedes the ultimate swelling and lysis. This shrinkage results from activation of Ca2+-sensitive K+ (KCa3.1) and Cl− channels (TM
Externí odkaz:
https://doaj.org/article/e82f5523ff8f466f8f9e900bcb8b111e
Publikováno v:
Frontiers in Physiology, Vol 4 (2013)
Local purinergic signals modulate renal tubular transport. Acute activation of renal epithelial P2 receptors causes inhibition of epithelial transport and thus, should favor increased water and salt excretion by the kidney. So far only a few studies
Externí odkaz:
https://doaj.org/article/46de85315c1f4533ae7b034c8d415c91
Autor:
Helle A. Praetorius
Publikováno v:
Praetorius, H 2021, ' The bacteria and the host : a story of purinergic signaling in urinary tract infections ', American journal of physiology. Cell physiology, vol. 321, no. 1, pp. C134-C146 . https://doi.org/10.1152/ajpcell.00054.2021
The local environment forces a selection of bacteria that might invade the urinary tract, allowing only the most virulent to access the kidney. Quite similar to the diet in setting the stage for the gut microbiome, renal function determines the condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3752c6b3fa7d059d53950aec34eca80
https://pubmed.ncbi.nlm.nih.gov/33979212
https://pubmed.ncbi.nlm.nih.gov/33979212
Autor:
Helle A. Praetorius, Samuel L Svendsen, Mads V. Sorensen, Thi Thuy Linh Hoang, Peder Berg, Jens Leipziger
Publikováno v:
Berg, P, Svendsen, S L, Hoang, T T L, Praetorius, H A, Sørensen, M V & Leipziger, J 2021, ' Impaired renal HCO 3-secretion in CFTR deficient mice causes metabolic alkalosis during chronic base-loading ', Acta Physiologica, vol. 231, no. 3, e13591 . https://doi.org/10.1111/apha.13591
Aim: Cystic fibrosis patients have an increased risk of developing metabolic alkalosis presumably as a result of altered renal HCO3- handling. In this study, we directly assess the kidneys’ ability to compensate for a chronic base-load in the absen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b4f2907f89f3036aa3ac3ef89dc4f9
https://doi.org/10.1111/apha.13591
https://doi.org/10.1111/apha.13591
Autor:
Helle A. Praetorius, Anne-Mette Hvas, Peter Rubak, Mette G. Christensen, Aimi D.M. Hamilton, Nanna Johnsen, Marianne Skals
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 16
International Journal of Molecular Sciences, Vol 21, Iss 5652, p 5652 (2020)
Christensen, M G, Johnsen, N, Skals, M, Hamilton, A D M, Rubak, P, Hvas, A M & Praetorius, H 2020, ' Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis ', International Journal of Molecular Sciences, vol. 21, no. 16, 5652, pp. 1-18 . https://doi.org/10.3390/ijms21165652
Christensen, M G, Johnsen, N, Skals, M, Hamilton, A D M, Rubak, P, Hvas, A M & Praetorius, H 2020, ' Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis ', International Journal of Molecular Sciences, vol. 21, no. 16, 5652 . https://doi.org/10.3390/ijms21165652
Volume 21
Issue 16
International Journal of Molecular Sciences, Vol 21, Iss 5652, p 5652 (2020)
Christensen, M G, Johnsen, N, Skals, M, Hamilton, A D M, Rubak, P, Hvas, A M & Praetorius, H 2020, ' Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis ', International Journal of Molecular Sciences, vol. 21, no. 16, 5652, pp. 1-18 . https://doi.org/10.3390/ijms21165652
Christensen, M G, Johnsen, N, Skals, M, Hamilton, A D M, Rubak, P, Hvas, A M & Praetorius, H 2020, ' Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis ', International Journal of Molecular Sciences, vol. 21, no. 16, 5652 . https://doi.org/10.3390/ijms21165652
Urosepsis is a potentially life-threatening, systemic reaction to uropathogenic bacteria entering the bloodstream of the host. One of the hallmarks of sepsis is early thrombocyte activation with a following fall in circulating thrombocytes as a resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d07e6138c44b67b972563f8a89e861
Autor:
Helle A. Praetorius, Jens Leipziger
Publikováno v:
Leipziger, J & Praetorius, H 2020, ' Renal Autocrine and Paracrine Signaling : A Story of Self-protection ', Physiological Reviews, vol. 100, no. 3, pp. 1229-1289 . https://doi.org/10.1152/physrev.00014.2019
Autocrine and paracrine signaling in the kidney adds an extra level of diversity and complexity to renal physiology. The extensive scientific production on the topic precludes easy understanding of the fundamental purpose of the vast number of molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45b89e31e100e969351d471dda314cd
https://pure.au.dk/portal/da/publications/renal-autocrine-and-paracrine-signaling(dd24e1f1-bd81-456c-ad5c-08db6c7df890).html
https://pure.au.dk/portal/da/publications/renal-autocrine-and-paracrine-signaling(dd24e1f1-bd81-456c-ad5c-08db6c7df890).html
Autor:
Peder, Berg, Samuel L, Svendsen, Thi Thuy Linh, Hoang, Helle A, Praetorius, Mads V, Sorensen, Jens, Leipziger
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 231(3)
Cystic fibrosis patients have an increased risk of developing metabolic alkalosis presumably as a result of altered renal HCOComprehensive urine and blood acid-base analyses were done in anaesthetized WT mice or mice lacking either CFTR or pendrin, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0ca2e359093a8a87dffa6c2ed5b3d08
https://pubmed.ncbi.nlm.nih.gov/33270356
https://pubmed.ncbi.nlm.nih.gov/33270356
Autor:
Søren Brøgger Christensen, Helle A. Praetorius, Jesper V. Møller, Pankaj Sehgal, Paula Szalai, Nikolai Engedal, Poul Nissen, Claus Olesen
Publikováno v:
Sehgal, P, Szalai, P, Olesen, C, Praetorius, H A, Nissen, P, Christensen, S B, Engedal, N & Møller, J V 2017, ' Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+ depletion and the unfolded protein response ', Journal of Biological Chemistry, vol. 292, pp. 19656-19673 . https://doi.org/10.1074/jbc.M117.796920
Calcium (Ca2+) is a fundamental regulator of cell signaling and function. Thapsigargin (Tg) blocks the sarco/endoplasmic reticulum (ER) Ca2+-ATPase (SERCA), disrupts Ca2+ homeostasis, and causes cell death. However, the exact mechanisms whereby SERCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab344f2ce47b2460055b73b630f6cb1
https://doi.org/10.1074/jbc.m117.796920
https://doi.org/10.1074/jbc.m117.796920
Autor:
Jens Leipziger, Helle A. Praetorius
Publikováno v:
Leipziger, J & Praetorius, H 2020, ' How does aldosterone work in the b-intercalated cell? ', Journal of the American Society of Nephrology, vol. 31, no. 3, pp. 451-452 . https://doi.org/10.1681/ASN.2020010077
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab03b3d01dc181f49770a8e48361d6aa
https://doi.org/10.1681/asn.2020010077
https://doi.org/10.1681/asn.2020010077