P2X7 accelerate tissue fibrosis via metalloproteinase 8‐dependent macrophage infiltration in a murine model of unilateral ureteral obstruction

Autor: Jacob Rudjord Therkildsen, Stine Julie Tingskov, Michael Schou Jensen, Helle Praetorius, Rikke Nørregaard

Publikováno v: Physiological Reports, Vol 11, Iss 22, Pp n/a-n/a (2023)

Abstract Renal fibrosis is tightly associated with chronic kidney disease, irrespective of the underlying pathogenesis. We previously demonstrated mild antifibrotic effects of targeting the P2X7 receptor in a pyelonephritis model. Reduced P2X7R‐act

Externí odkaz: https://doaj.org/article/ad10cd4bbc1b4df7878d0986cace4659

Europhysiology 2022: Let’s meet for real

Autor: Helle Praetorius, William Louch

Publikováno v: Praetorius, H & Louch, W E 2022, ' Europhysiology 2022 : Let’s meet for real ', Acta Physiologica, vol. 235, no. 2, e13825 . https://doi.org/10.1111/apha.13825

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e7965d3785d97322087ab41f6a9870
https://doi.org/10.1111/apha.13825

Acute pyelonephritis: Increased plasma membrane targeting of renal aquaporin‐2

Autor: Christina V. Ernstsen, Frédéric H. Login, Anne‐Sofie B. Schelde, Jacob R. Therkildsen, Jakob Møller‐Jensen, Rikke Nørregaard, Helle Prætorius, Lene N. Nejsum

Publikováno v: Ernstsen, C V, Login, F H, Schelde, A-S B, Therkildsen, J R, Møller-Jensen, J, Nørregaard, R, Prætorius Øhrwald, H & Nejsum, L N 2022, ' Acute pyelonephritis : increased plasma membrane targeting of renal aquaporin-2 ', Acta Physiologica, vol. 234, no. 2, e13760 . https://doi.org/10.1111/apha.13760
Ernstsen, C V, Login, F H, Schelde, A S B, Therkildsen, JR, Møller-Jensen, J, Nørregaard, R, Prætorius, H & Nejsum, L N 2022, ' Acute pyelonephritis : Increased plasma membrane targeting of renal aquaporin-2 ', Acta Physiologica, vol. 234, no. 2, e13760 . https://doi.org/10.1111/apha.13760

AIM: Aquaporin-2 (AQP2) shuttling between intracellular vesicles and the apical plasma membrane is pivotal in arginine vasopressin-mediated urine concentration and is dysregulated in multiple diseases associated with water balance disorders. Children

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::651e174f41340fdc1424097089bca4f3
https://doi.org/10.1111/apha.13760

Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances: Another link between innate immunity and coagulation

Autor: Julie Brogaard Larsen, Rasmus Pihl, Mathies Appel Aggerbeck, Kim Michael Larsen, Christine Lodberg Hvas, Nanna Johnsen, Mette G. Christensen, Helle Praetorius, Anne-Mette Hvas, Steffen Thiel

Publikováno v: Larsen, J B, Pihl, R, Aggerbeck, M A, Larsen, K M, Hvas, C L, Johnsen, N, Christensen, M G, Praetorius, H, Hvas, A-M & Thiel, S 2023, ' Inter-α-inhibitor heavy chain H4 and sepsis-related coagulation disturbances : Another link between innate immunity and coagulation ', Research and Practice in Thrombosis and Haemostasis, vol. 7, no. 2, 100078 . https://doi.org/10.1016/j.rpth.2023.100078

BACKGROUND: The protease inhibitor inter-α-inhibitor heavy chain H4 (ITIH4) has been described as an acute-phase reactant and could potentially aid in sepsis monitoring and prognostication.OBJECTIVES: To investigate ITIH4 plasma levels in sepsis pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c4bc81fda1c690a6bd21087d9dab02
https://doi.org/10.1016/j.rpth.2023.100078

How Does Aldosterone Work in the

Autor: Jens, Leipziger, Helle, Praetorius

Publikováno v: J Am Soc Nephrol

BACKGROUND: Aldosterone activates the intercalated cell mineralocorticoid receptor, which is enhanced with hypokalemia. Whether this receptor directly regulates the intercalated cell chloride/bicarbonate exchanger pendrin is unclear, as are potassium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db2827c3df091c5ee4e4eda5de321478
https://pubmed.ncbi.nlm.nih.gov/32054691