Výsledky vyhledávání - "Hella Kenneweg"

Akademický článek

Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments

Autor: David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K. Christopher Garcia, Thomas D. Müller, Jacob Piehler

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

The contribution of ligands for cytokine receptor dimerization is still not fully understood. Here, the authors show the efficient ligand-induced dimerization of type II interleukin-4 receptor at the plasma membrane and the kinetic trapping of signal

Externí odkaz: https://doaj.org/article/468ea883eae44e69b79d347c613a8344

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Four-color single-molecule imaging with engineered tags resolves the molecular architecture of signaling complexes in the plasma membrane

Autor: Changjiang You, Florian Eull, Jacob Piehler, Ulrich Rothbauer, Stephan Wilmes, Rainer Kurre, Oliver Birkholz, Hella Kenneweg, Christian Richter, Junel Sotolongo Bellón, Mark R. Walter

Publikováno v: Cell reports methods. 2(2)

Localization and tracking of individual receptors by single-molecule imaging opens unique possibilities to unravel the assembly and dynamics of signaling complexes in the plasma membrane. For this purpose, we here developed a comprehensive workflow f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9eb340bc57fed8b0d0a3bab267baaf2
https://pubmed.ncbi.nlm.nih.gov/35474965

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The photosystem II-associated Cah3 in Chlamydomonas enhances the O2 evolution rate by proton removal

Autor: Vasily V. Terentyev, Hella Kenneweg, Suleyman I. Allakhverdiev, Sergey Chernyshov, Göran Samuelsson, Bertil Andersson, Joachim Buchta, Wolfgang Junge, Tatiana Shutova, Julia Nikitina, Vyacheslav V. Klimov, Holger Dau

Publikováno v: The EMBO Journal. 27:782-791

Water oxidation in photosystem II (PSII) is still insufficiently understood and is assumed to involve HCO(3)(-). A Chlamydomonas mutant lacking a carbonic anhydrase associated with the PSII donor side shows impaired O(2) evolution in the absence of H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3737e7d41814c639bb7fae906750457
https://doi.org/10.1038/emboj.2008.12

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High efficiency cell-specific targeting of cytokine activity

Autor: Yann Bordat, Franciane Paul, Stephan Wilmes, Florence Apparailly, Jan Tavernier, Guillaume Cartron, Gilles Uzé, Markus Staufenbiel, Stefaan De Koker, José Van der Heyden, Geneviève Garcin, Jacob Piehler

Publikováno v: Nature Communications; Vol 5
Nature Communications
Nature Communications, Nature Publishing Group, 2014, 5 (1), ⟨10.1038/ncomms4016⟩
Nature Communications, 2014, 5 (1), ⟨10.1038/ncomms4016⟩

International audience; Systemic toxicity currently prevents exploiting the huge potential of many cytokines for medical applications. Here we present a novel strategy to engineer immunocytokines with very high targeting efficacies. The method lies i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f1f2acf7720c3ec88d563ae2163e9c2

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