Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in cells.

Autor: Li Y; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, Germany., Arghittu SM; Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, Frankfurt am Main, Germany.; IMPRS on Cellular Biophysics, Max-von-Laue-Str. 3, Frankfurt am Main, Germany., Dietz MS; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, Germany., Hella GJ; Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, Frankfurt am Main, Germany., Haße D; Department of Chemistry, Bielefeld University, Universitaetsstr. 25, Bielefeld, Germany., Ferraris DM; Department of Pharmaceutical Sciences, University of Piemonte Orientale, Largo Donegani 2, Novara, Italy., Freund P; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, Germany., Barth HD; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, Germany., Iamele L; Department of Molecular Medicine, University of Pavia, Immunology and General Pathology Section, Via Ferrata 9, Pavia, Italy., de Jonge H; Department of Molecular Medicine, University of Pavia, Immunology and General Pathology Section, Via Ferrata 9, Pavia, Italy., Niemann HH; Department of Chemistry, Bielefeld University, Universitaetsstr. 25, Bielefeld, Germany., Covino R; Frankfurt Institute for Advanced Studies, Ruth-Moufang-Str. 1, Frankfurt am Main, Germany. covino@fias.uni-frankfurt.de.; IMPRS on Cellular Biophysics, Max-von-Laue-Str. 3, Frankfurt am Main, Germany. covino@fias.uni-frankfurt.de.; Institute of Computer Science, Goethe-University Frankfurt, Robert-Mayer-Str. 11-15, Frankfurt am Main, Germany. covino@fias.uni-frankfurt.de., Heilemann M; Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 7, Frankfurt am Main, Germany. heilemann@chemie.uni-frankfurt.de.; IMPRS on Cellular Biophysics, Max-von-Laue-Str. 3, Frankfurt am Main, Germany. heilemann@chemie.uni-frankfurt.de.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 02; Vol. 15 (1), pp. 9486. Date of Electronic Publication: 2024 Nov 02.