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pro vyhledávání: '"Helit, Rozen"'
Autor:
Rotem Lange, Allan Bar-Sinai, Adi Salzberg, Ze'ev Paroush, Shaked Bar-Cohen, Tatyana Kushnir, David Engelberg, Navit Mooshayef, Helit Rozen
Publikováno v:
Genetics. 214:109-120
Excessive RTK signaling, often caused by activating mutations in Ras, Raf and/or MEK, occurs in most human tumors. Intriguingly, confirmed cancer-driver mutations in the downstream effector kinase, ERK, have not been reported. To test if... Receptor
Autor:
Tatyana, Kushnir, Shaked, Bar-Cohen, Navit, Mooshayef, Rotem, Lange, Allan, Bar-Sinai, Helit, Rozen, Adi, Salzberg, David, Engelberg, Ze'ev, Paroush
Publikováno v:
Genetics
Receptor tyrosine kinase signaling plays prominent roles in tumorigenesis, and activating oncogenic point mutations in the core pathway components Ras, Raf, or MEK are prevalent in many types of cancer. Intriguingly, however, analogous oncogenic muta