Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Helinä Kahma"'
Autor:
Marie-Noëlle, Paludetto, Mika, Kurkela, Helinä, Kahma, Janne T, Backman, Mikko, Niemi, Anne M, Filppula
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals.
This study aimed to explore the cytochrome P450 (CYP) metabolic and inhibitory profile of hydroxychloroquine (HCQ). Hydroxychloroquine metabolism was studied using human liver microsomes (HLMs) and recombinant CYP enzymes. The inhibitory effects of H
Autor:
Mikko Niemi, Mikko Neuvonen, Janne T. Backman, Terhi Launiainen, Anne M. Filppula, Jani Katajamäki, Helinä Kahma, Aleksi Tornio, Laura Aurinsalo, Jenni Viinamäki, Marie-Noëlle Paludetto
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 162
We developed an in vitro high-throughput cocktail assay with nine major drug-metabolizing CYP enzymes, optimized for screening of time-dependent inhibition. The method was applied to determine the selectivity of the time-dependent CYP2C8 inhibitors g
Autor:
Terhi Launiainen, Janne T. Backman, Mikko Neuvonen, Rheem A. Totah, Helinä Kahma, Eric A. Evangelista, Jenni Viinamäki, Anne M. Filppula
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 47(4)
Clopidogrel acyl-β-d-glucuronide is a mechanism-based inhibitor of cytochrome P450 2C8 in human liver microsomes (HLMs). However, time-dependent inactivation (TDI) of CYP2C8 could not be detected in an earlier study in human recombinant CYP2C8 (Supe
Autor:
Janne T. Backman, Mikko Neuvonen, Terhi Launiainen, Aleksi Tornio, Helinä Kahma, Jenni Viinamäki, Laura Aurinsalo, Anne M. Filppula
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S19
Autor:
Mikko Niemi, Mikko Neuvonen, Janne T. Backman, Matti K. Itkonen, Pertti J. Neuvonen, Mikko T. Holmberg, Helinä Kahma, Moshe Finel, E. Katriina Tarkiainen, Aleksi Tornio, Anne M. Filppula
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(2)
The antiplatelet drug clopidogrel is metabolized to an acyl-β-d-glucuronide, which causes time-dependent inactivation of CYP2C8. Our aim was to characterize the UDP-glucuronosyltransferase (UGT) enzymes that are responsible for the formation of clop
Autor:
Janne T. Backman, Pertti J. Neuvonen, Mikko T. Holmberg, Moshe Finel, Anne M. Filppula, Aleksi Tornio, Helinä Kahma, Mikko Niemi, Mikko Neuvonen, E. Katriina Tarkiainen, Matti K. Itkonen
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:S36