Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

Autor: Erik Jung, Matthias Osswald, Miriam Ratliff, Helin Dogan, Ruifan Xie, Sophie Weil, Dirk C. Hoffmann, Felix T. Kurz, Tobias Kessler, Sabine Heiland, Andreas von Deimling, Felix Sahm, Wolfgang Wick, Frank Winkler

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Whether the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have a different role in glioblastoma progression and resistance to therapies is currently unclear. Here, the authors, by long-term trackin

Externí odkaz: https://doaj.org/article/a219a87b2e5c41669d28b24deca0d0b9

Rapid-CNS2: rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof-of-concept study

Autor: Areeba Patel, Helin Dogan, Alexander Payne, Elena Krause, Philipp Sievers, Natalie Schoebe, Daniel Schrimpf, Christina Blume, Damian Stichel, Nadine Holmes, Philipp Euskirchen, Jürgen Hench, Stephan Frank, Violaine Rosenstiel-Goidts, Miriam Ratliff, Nima Etminan, Andreas Unterberg, Christoph Dieterich, Christel Herold-Mende, Stefan M. Pfister, Wolfgang Wick, Matthew Loose, Andreas von Deimling, Martin Sill, David T. W. Jones, Matthias Schlesner, Felix Sahm

Publikováno v: Acta Neuropathologica. 143:609-612

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57f87b0594863199e5aed85d9d75a6e5
https://doi.org/10.1007/s00401-022-02415-6

Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1

Autor: Matija Snuderl, Zied Abdullaev, Christel Herold-Mende, Ralf Ketter, Uta Schick, Zane Jaunmuktane, David T.W. Jones, Christian Mawrin, Daniel Schrimpf, Leonille Schweizer, Christina Blume, Miriam Ratliff, Arnault Tauziède-Espariat, Pascale Varlet, Arie Perry, Felix Sahm, Damian Stichel, Walter Stummer, Martin Hasselblatt, Jürgen Hench, Stefan M. Pfister, Pieter Wesseling, Guido Reifenberger, Jens Schittenhelm, Helin Dogan, Andreas von Deimling, David W. Ellison, Christian Hartmann, Philipp Sievers, Melike Pekmezci, Wolfgang Wick, David E. Reuss, Stephan Frank, Martin Sill, Sebastian Brandner, Stéphanie Puget, Benno Küsters, Kenneth Aldape, Andreas Unterberg

Publikováno v: Acta Neuropathologica, 141, 281-290
Acta Neuropathologica, 141, 2, pp. 281-290
Sievers, P, Sill, M, Blume, C, Tauziede-Espariat, A, Schrimpf, D, Stichel, D, Reuss, D E, Dogan, H, Hartmann, C, Mawrin, C, Hasselblatt, M, Stummer, W, Schick, U, Hench, J, Frank, S, Ketter, R, Schweizer, L, Schittenhelm, J, Puget, S, Brandner, S, Jaunmuktane, Z, Küsters, B, Abdullaev, Z, Pekmezci, M, Snuderl, M, Ratliff, M, Herold-Mende, C, Unterberg, A, Aldape, K, Ellison, D W, Wesseling, P, Reifenberger, G, Wick, W, Perry, A, Varlet, P, Pfister, S M, Jones, D T W, von Deimling, A, Sahm, F & The German Consortium “Aggressive Meningiomas” 2021, ' Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1 ', Acta Neuropathologica, vol. 141, no. 2, pp. 281-290 . https://doi.org/10.1007/s00401-020-02247-2
Acta Neuropathologica, 141(2), 281-290. Springer Verlag
Acta Neuropathologica

Clear cell meningioma represents an uncommon variant of meningioma that typically affects children and young adults. Although an enrichment of loss-of-function mutations in the SMARCE1 gene has been reported for this subtype, comprehensive molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb13b0f61a78e72f828c6744db421a9e
http://www.scopus.com/inward/record.url?scp=85097560192&partnerID=8YFLogxK

Dissecting intra-tumoral heterogeneity in meningiomas on single cell level unveils distinct tumor subpopulations and a differential tumor microenvironment between meningioma subgroups

Autor: Christina Blume, Helin Dogan, Michael Ritter, Lisa Schweizer, Wolfgang Wick, Michael Weller, Matthias Mann, Michel Kalamarides, Andreas von Deimling, Matthias Schlesner, Felix Sahm

Publikováno v: WFNOS 2022 Abstract Book.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a74174ef7389caa3b4a79a272375e44b
https://doi.org/10.14791/btrt.2022.10.f-1340

PATH-46. COMPUTATIONAL HISTOPATHOLOGY INFORMED RAPID TARGETED NANOPORE SEQUENCING ENABLES AFFORDABLE NEXT DAY REPORTING OF COMPREHENSIVE MOLECULAR MARKERS FOR CNS TUMOUR DIAGNOSTICS

Autor: Areeba Patel, Helin Dogan, Alexander Jung, Zaira Seferbekova, Alexander Payne, Michael Ritter, Daniel Schrimpf, Damian Stichel, Stefan Hamelmann, Christina Blume, Philipp Euskirchen, Violaine Goidts, Martin Sill, Stefan Pfister, Matthew Loose, Wolfgang Wick, Andreas von Deimling, David T Jones, Matthias Schlesner, Moritz Gerstung, Felix Sahm

Publikováno v: Neuro-Oncology. 24:vii161-vii161

BACKGROUND Integrative brain tumour diagnostics indisputably requires comprehensive reporting of molecular markers. The 2021 WHO classification of central nervous system (CNS) tumours substantially increased the set of markers for routine evaluation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f52c486fcd3d7faf845c20ed0362f928
https://doi.org/10.1093/neuonc/noac209.619