Zobrazeno 1 - 10
of 15 728
pro vyhledávání: '"Helicase P"'
Autor:
Alexei Yu. Kostygov, Karolína Skýpalová, Natalia Kraeva, Elora Kalita, Cameron McLeod, Vyacheslav Yurchenko, Mark C. Field, Julius Lukeš, Anzhelika Butenko
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background In trypanosomatids, a group of unicellular eukaryotes that includes numerous important human parasites, cis-splicing has been previously reported for only two genes: a poly(A) polymerase and an RNA helicase. Conversely, trans-spli
Externí odkaz:
https://doaj.org/article/f6fb216fcfeb4a7b8a4e909bf195155a
Publikováno v:
Journal of Vector Borne Diseases, Vol 61, Iss 4, Pp 536-546 (2024)
Background & objectives: RNA viruses are complex pathogens in terms of their genetic makeup, mutation frequency, and transmission modes. They contain the RNA helicase enzyme, which plays a crucial role in the viral genome replication process. This wo
Externí odkaz:
https://doaj.org/article/efda1a2b06be4e83ab23bc5dd95bffb4
Akademický článek
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Autor:
Kunqi Su, Zhuochen Zhao, Yuying Wang, Shiqi Sun, Xiaofeng Liu, Chunfeng Zhang, Yang Jiang, Xiaojuan Du
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Aberrant accumulation of R-loops leads to DNA damage, genome instability and even cell death. Therefore, the timely removal of harmful R-loops is essential for the maintenance of genome integrity. Nucleolar R-loops occupy up to 50
Externí odkaz:
https://doaj.org/article/ddc25dd671434f62bd3c4da8f0bed35b
Publikováno v:
Journal of Vector Borne Diseases, Vol 61, Iss 3, Pp 389-399 (2024)
Background & objectives: The battle against malaria has witnessed remarkable progress in recent years, characterized by increased funding, development of life-saving tools, and a significant reduction in disease prevalence. Yet, the formidable challe
Externí odkaz:
https://doaj.org/article/2c3f39cf826a431d80977169e3fd85de
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal tumor with an ill-defined pathogenesis. DExD box (DDX) family genes are widely distributed and involved in various RNA metabolism and cellular biogenesis; their dysregulat
Externí odkaz:
https://doaj.org/article/1f8a4e614dd843c7865bebd72ab98241
Publikováno v:
Liaquat National Journal of Primary Care, Vol 6, Iss 2, Pp 165-173 (2024)
Incidences of dengue-virus infection are increasing globally. Around 3.90 billion population is at high risk of infection. There is no cure/ prevention available. Hence aim of the current review was the evaluation of current development and prospect
Externí odkaz:
https://doaj.org/article/e80dc5320c594d6da69804be68a13396
Publikováno v:
Comparative Immunology Reports, Vol 7, Iss , Pp 200172- (2024)
The large superfamily of DExD/H box RNA helicases are involved in various life processes, such as RNA metabolism, transcriptional regulation, translation, tumorigenesis, cell cycle, and viral infection, and RIG-like receptors (RLRs) in the superfamil
Externí odkaz:
https://doaj.org/article/5da4e5d7cb9e44018b1a68ae7cdfc71e
Autor:
Ashley J. Parkes, Sabesan Anandavijayan, Anna Lou-Hing, Olivia Downs, Tom Killelea, Louise Martin, Fiorela Kapllanaj, Edward L. Bolt
Publikováno v:
Royal Society Open Science, Vol 11, Iss 12 (2024)
Human DDX49 is an emerging target in cancer progression and retroviral diseases through its essential roles in nucleolar RNA processing. Here, we identify nuclease activity of human DDX49, which requires active site aspartate residues within a conser
Externí odkaz:
https://doaj.org/article/bfb3d6d703454286a1d4dc754928c36b
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 7, Pp 959-964 (2024)
Objective To explore the role of DExD/H box helicase 60(DDX60) in the development of systemic lupus erythematosus (SLE) by regulating the dsDNA-cGAS-IFN-Ⅰ pathway. Methods Differences in DDX60 mRNA level in peripheral blood mononuclear cells (PBMCs
Externí odkaz:
https://doaj.org/article/5d1a7df73a7249a6994b8a5b66bde0e9