Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Heli Ylä-Outinen"'
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 7, Iss 9, Pp n/a-n/a (2019)
Abstract Background Type 1 neurofibromatosis (NF1) is a genetic tumor predisposing Rasopathy. NF1 patients have an increased risk for developing benign and malignant tumors, but the occurrence of intestinal tumors has not been investigated at the pop
Externí odkaz:
https://doaj.org/article/fa4ef33f50ff477b832dbb18a28c9356
Autor:
Aarne Oikarinen, Vesa Aaltonen, Juha Peltonen, Seija-Liisa Karvonen, Jussi Koivunen, Heli Ylä-Outinen
Publikováno v:
Archives of Dermatological Research. 296:547-554
Type 1 neurofibromatosis syndrome (NF1) has been linked with mutations of the NF1 gene which encodes tumor suppressor neurofibromin, a regulator of Ras-MAPK signaling. In human epidermis, keratinocytes express NF1 tumor suppressor and it may have a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4617d059b9ab592d4dae2ad39487d720
https://doi.org/10.1007/s00403-005-0564-x
https://doi.org/10.1007/s00403-005-0564-x
Publikováno v:
Archives of Dermatological Research. 296:465-472
Capacitative calcium entry and calcium wave propagation were studied in keratinocytes from healthy volunteers and patients with type 1 neurofibromatosis (NF1) in calcium-depleted and in low calcium culture medium. In previous studies, we found eviden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78cc87036b83596807980501d926db4
https://doi.org/10.1007/s00403-004-0538-4
https://doi.org/10.1007/s00403-004-0538-4
Autor:
Kari Majamaa, Harri Rusanen, Juha Peltonen, Ilmo E. Hassinen, Heli Ylä-Outinen, Johanna Annunen, Aino Laurila
Publikováno v:
Cell Motility and the Cytoskeleton. 53:231-238
The cytoskeleton, mainly composed of actin filaments, microtubules, and intermediate filaments, is involved in cell proliferation, the maintenance of cell shape, and the formation of cellular junctions. The organization of the intermediate filaments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84150561868351552a48143fa3997476
https://doi.org/10.1002/cm.10066
https://doi.org/10.1002/cm.10066
Autor:
Heli Ylä-Outinen, Ann-Sofi Björkstrand, Marja Nissinen, Juha Peltonen, Marja Paloniemi, Seija-Liisa Karvonen, Timo Korkiamäki, Sirkku Peltonen, Jussi Koivunen
Publikováno v:
Laboratory Investigation. 82:353-361
We have previously shown that NF1 (type 1 neurofibromatosis) p21ras GTPase-activating tumor suppressor protein undergoes major relocalization during the formation of cell-cell junctions in differentiating keratinocytes in vitro. This prompted us to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1730e1ce37451b3e931c45e2b5d06e
https://doi.org/10.1038/labinvest.3780429
https://doi.org/10.1038/labinvest.3780429
Autor:
Jaakko Karvonen, Juha Peltonen, Kati Pummi, Marja Nissinen, Timo Korkiamäki, Heli Ylä-Outinen, Harri Teerikangas, Seija-Liisa Karvonen
Publikováno v:
Journal of Investigative Dermatology. 114(4):693-700
Intracellular calcium plays an important part in the regulation of proliferation and differentiation of keratinocytes. Detached from their in vivo environment, cultured psoriatic keratinocytes were investigated by monitoring free intracellular calciu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c6b0f486b34ce79c411cfcfadebf4a
Autor:
Minna Pöyhönen, Matti Laato, Timo Korkiamäki, Heli Ylä-Outinen, Jaakko Karvonen, Juha Peltonen, Seija-Liisa Karvonen, Sirkku Peltonen, Jussi Koivunen
Publikováno v:
Journal of Investigative Dermatology. 114(3):473-479
The expression and subcellular localization of neurofibromatosis type 1 tumor suppressor was studied in keratinocytes induced to differentiate by increased Ca2+ concentration of the culture medium. Differentiating keratinocytes became intensely immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d524424161cb2e7255dd13b5755fec
Autor:
Juha Peltonen, Ann-Sofi Björkstrand, Matti Laato, Outi Hirvonen, Vesa Aaltonen, Marko Vähä-Kreula, Jouni Lakkakorpi, Heli Ylä-Outinen
Publikováno v:
Journal of Investigative Dermatology. 110(3):232-237
We first studied expression of neurofibromin by immunohistochemistry in scars obtained from operations involving areas of healing wounds. The results demonstrated increased immunoreactivity for neurofibromin in the fibroblastic cell population of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055d86108932469cde7806f6f8bc20c2
Autor:
H. Kalimo, Vesa Aaltonen, H. Hirvonen, Juha Peltonen, Heli Ylä-Outinen, Outi Hirvonen, Jouni Lakkakorpi, M. Rossi, Seija-Liisa Karvonen
Publikováno v:
Journal of Neurocytology. 27:939-951
Mutations of the NF1 tumor suppressor gene cause type 1 neurofibromatosis, characterized by multiple tumors of the peripheral nerves, as well as other tumor types. The NF1 protein, neurofibromin, is intricately linked to the cell growth regulatory si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43d11a9250444a51de9410f9e2749ec2
https://doi.org/10.1023/a:1006905224474
https://doi.org/10.1023/a:1006905224474
Publikováno v:
Journal of Investigative Dermatology. 105(5):664-667
Neurofibromin enhances the inactivation of protooncogene p21ras and has been suggested to function as a regulator of cell growth and differentiation. In normal skin, neurofibromin is particularly abundant in the basal keratinocytes of epidermis. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dee802d347c02aebf9dc0103c02b94