Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Heli Valtanen"'
Publikováno v:
Karolinska Institutet
Membrane type 1 matrix metalloproteinase (MT1-MMP) is a membrane-bound proteinase and a cell-surface receptor and activator of gelatinase A in normal and neoplastic cells. We have expressed and purified a soluble deletion mutant of MT1-MMP lacking th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602253c8e293651e421d2813cefd5830
https://doi.org/10.1006/prep.2000.1216
https://doi.org/10.1006/prep.2000.1216
Autor:
Oula Penate, Medina, Kalevi, Kairemo, Heli, Valtanen, Aino, Kangasniemi, Sami, Kaukinen, Ilona, Ahonen, Perttu, Permi, Arto, Annila, Mia, Sneck, Juha M, Holopainen, Sirkka-Liisa, Karonen, Paavo K J, Kinnunen, Erkki, Koivunen
Publikováno v:
Anticancer research. 25(1A)
Tumors express MMP-2 and MMP-9 gelatinases, which are involved in the formation of tumor vasculature. This suggests that a tumor and its surrounding neovasculature can be visualized by a sensitive gelatinase recognition method. We have studied tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38a64440ebfadf610975189fa6c586a2
https://pubmed.ncbi.nlm.nih.gov/15816516
https://pubmed.ncbi.nlm.nih.gov/15816516
Publikováno v:
Combinatorial chemistryhigh throughput screening. 6(1)
Screening of phage display libraries allows rapid identification of peptides binding to a target. However, functional analysis of the phage sequences and their reproduction as soluble and stable peptides are often the most time-consuming part in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3249d1a17db8c6a91f45e45667b955a7
https://pubmed.ncbi.nlm.nih.gov/12570750
https://pubmed.ncbi.nlm.nih.gov/12570750
Autor:
Kim Anh Do, Raphael E. Pollock, Limor Chen, Johanna Lahdenranta, Virginia J. Yao, Heli Valtanen, Martin Trepel, Ricardo J. Giordano, Wadih Arap, Christopher J. Logothetis, Keith A. Baggerly, Lisa M. Weavind, Patricia Troncoso, Renata Pasqualini, Corazon D. Bucana, Dolores J. Cahill, Claudia I. Vidal, Anne L. Flamm, Erkki Koivunen, Gregory H. Botz, Marina Cardó-Vila, Marshall E. Hicks, Rebecca D. Pentz, Paul J. Mintz, Peter U. Ardelt, Mikhail G. Kolonin
Publikováno v:
ResearcherID
The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980a56b87507934e32f8a41f321cd3d3
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/72328
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/72328
Publikováno v:
Karolinska Institutet
Membrane-type-1 matrix metalloproteinase (MT1-MMP) has transmembrane and cytoplasmic domains, which target it to invasive fronts. We analyzed the role of the cytoplasmic tail by expressing wild type MT1-MMP and three mutants with progressively trunca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc0e7b4c158f4f855753a0baaaac1fc
https://pubmed.ncbi.nlm.nih.gov/10748199
https://pubmed.ncbi.nlm.nih.gov/10748199
Autor:
Wadih Arap, Oula Penate Medina, Heli Valtanen, Erkki Ruoslahti, Pia Heikkilä, Tuula Salo, Renata Pasqualini, Erkki Koivunen, Carmela Kantor, Timo Sorsa, Yrjö T. Konttinen, Aija Rainisalo, Carl G. Gahmberg
Publikováno v:
University of Helsinki
Several lines of evidence suggest that tumor growth, angiogenesis, and metastasis are dependent on matrix metalloproteinase (MMP) activity. However, the lack of inhibitors specific for the type IV collagenase/gelatinase family of MMPs has thus far pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5223ff2943495b3e2aedb3fdb96567bb
https://pubmed.ncbi.nlm.nih.gov/10429241
https://pubmed.ncbi.nlm.nih.gov/10429241
Publikováno v:
Journal of Biological Chemistry. 279:40246
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b8befc740154d31b48a88e37d81b8d
https://doi.org/10.1016/s0021-9258(20)72838-3
https://doi.org/10.1016/s0021-9258(20)72838-3
Autor:
Tanja-Maria Ranta, Heli Valtanen, Sami Kaukinen, Erkki Koivunen, Carl Gahmberg, Boermann, Otto C., Oyen, Wim J. G., Kalevi Kairemo
Publikováno v:
ResearcherID
University of Helsinki
University of Helsinki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::611ea686a1b847f42d73af845d493aaf
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000205501600027&KeyUID=WOS:000205501600027
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000205501600027&KeyUID=WOS:000205501600027
Publikováno v:
Karolinska Institutet
Human fibroblasts and HT-1080 fibrosarcoma cells express membrane-type-1 matrix metalloproteinase (MT1-MMP), the cell surface activator of gelatinase A, in separate forms of 63 kDa, 60 kDa and in some cases 43 kDa. In the present work the interrelati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df5d124f59d076c89b2999f8f307a23
http://www.ncbi.nlm.nih.gov/pubmed/9716492
http://www.ncbi.nlm.nih.gov/pubmed/9716492
Publikováno v:
Karolinska Institutet
Membrane type-1 matrix metalloproteinase (MT1-MMP) degrades extracellular matrix components directly and indirectly by activation of other matrix metalloproteinases (MMPs). In the present study, we have isolated and characterized the human MT1-MMP ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6226c3d4898e95f420653646bcca135
http://www.ncbi.nlm.nih.gov/pubmed/10721699
http://www.ncbi.nlm.nih.gov/pubmed/10721699