Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Heli Vaikkinen"'
Autor:
Siddharth Jayaraman, Claire Harris, Edith Paxton, Anne-Marie Donachie, Heli Vaikkinen, Richard McCulloch, James P J Hall, John Kenny, Luca Lenzi, Christiane Hertz-Fowler, Christina Cobbold, Richard Reeve, Tom Michoel, Liam J Morrison
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 4, p e0007262 (2019)
Antigenic variation is employed by many pathogens to evade the host immune response, and Trypanosoma brucei has evolved a complex system to achieve this phenotype, involving sequential use of variant surface glycoprotein (VSG) genes encoded from a la
Externí odkaz:
https://doaj.org/article/e97f4a4757b749a9a3f0afa32c365e78
Autor:
Tim Meyer, Teresa Marafioti, Sergio A. Quezada, Karl Peggs, Christos Toumpanakis, Martyn Caplin, Chrissie Thirlwell, Tu Vinh Luong, Amir Gander, Olagunju Ogunbiyi, Javier Herrero, Lucia Conde, Heli Vaikkinen, Pawan Dhami, Ayse U. Akarca, Alexa Childs, Yien Ning Sophia Wong, Clare Vesely
Supplementary Data from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b21416a7dce2193bc61d72e5612fc0c
https://doi.org/10.1158/1078-0432.22486557
https://doi.org/10.1158/1078-0432.22486557
Autor:
Tim Meyer, Teresa Marafioti, Sergio A. Quezada, Karl Peggs, Christos Toumpanakis, Martyn Caplin, Chrissie Thirlwell, Tu Vinh Luong, Amir Gander, Olagunju Ogunbiyi, Javier Herrero, Lucia Conde, Heli Vaikkinen, Pawan Dhami, Ayse U. Akarca, Alexa Childs, Yien Ning Sophia Wong, Clare Vesely
Purpose:The immune tumor microenvironment and the potential therapeutic opportunities for immunotherapy in small intestinal neuroendocrine tumors (siNET) have not been fully defined.Experimental Design:Herein, we studied 40 patients with primary and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e62c014a2e3243652c68f6bcf35aad
https://doi.org/10.1158/1078-0432.c.6532341
https://doi.org/10.1158/1078-0432.c.6532341
Autor:
Tim Meyer, Teresa Marafioti, Sergio A. Quezada, Karl Peggs, Christos Toumpanakis, Martyn Caplin, Chrissie Thirlwell, Tu Vinh Luong, Amir Gander, Olagunju Ogunbiyi, Javier Herrero, Lucia Conde, Heli Vaikkinen, Pawan Dhami, Ayse U. Akarca, Alexa Childs, Yien Ning Sophia Wong, Clare Vesely
Supplementary Table from Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33adef37e53562846258689ff6c5ee01
https://doi.org/10.1158/1078-0432.22486527
https://doi.org/10.1158/1078-0432.22486527
Autor:
Lucia Conde, Leah Ensell, Javier Herrero, Martyn Caplin, John A. Hartley, Christos Toumpanakis, Clare Vesely, Nischalan Pillay, Alexa Childs, Christopher D. Steele, Francesca M Rizzo, Pawan Dhami, Christina Thirlwell, Helen Lowe, Tim Meyer, Heli Vaikkinen, Tu Vinh Luong
Publikováno v:
Endocrine-Related Cancer
Single-cell profiling of circulating tumor cells (CTCs) as part of a minimally invasive liquid biopsy presents an opportunity to characterize and monitor tumor heterogeneity and evolution in individual patients. In this study, we aimed to compare sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c47baef0fb1caf6635e4cb3e8600fe
http://europepmc.org/articles/PMC8428071
http://europepmc.org/articles/PMC8428071
Autor:
Oladapo E. Olaniru, Ulrich Kadolsky, Shichina Kannambath, Heli Vaikkinen, Kathy Fung, Pawan Dhami, Shanta J. Persaud
The progress made in directed differentiation of stem cells has shown that understanding human pancreas development can provide cues for generating unlimited amounts of insulin-producing beta cells for transplantation therapy in diabetes. However, cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38d1c4127d93606f4044eac33a18b62c
https://doi.org/10.1101/2022.02.04.478971
https://doi.org/10.1101/2022.02.04.478971
Autor:
Oladapo Edward Olaniru, Ulrich Kadolsky, Shichina Kannambath, Heli Vaikkinen, Kathy Fung, Pawan Dhami, Shanta J. Persaud
Publikováno v:
Cell Metabolism. 35:184-199.e5
Current differentiation protocols have not been successful in reproducibly generating fully functional human beta cells in vitro, partly due to incomplete understanding of human pancreas development. Here, we present detailed transcriptomic analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76e5ed9af616438e189387f489fdc32
https://doi.org/10.1016/j.cmet.2022.11.009
https://doi.org/10.1016/j.cmet.2022.11.009
Autor:
Clare Vesely, Yien Ning Sophia Wong, Alexa Childs, Ayse U. Akarca, Pawan Dhami, Heli Vaikkinen, Lucia Conde, Javier Herrero, Olagunju Ogunbiyi, Amir Gander, Tu Vinh Luong, Chrissie Thirlwell, Martyn Caplin, Christos Toumpanakis, Karl Peggs, Sergio A. Quezada, Teresa Marafioti, Tim Meyer
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 28(12)
Purpose: The immune tumor microenvironment and the potential therapeutic opportunities for immunotherapy in small intestinal neuroendocrine tumors (siNET) have not been fully defined. Experimental Design: Herein, we studied 40 patients with primary a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1830786a8b25d863ebc3781ef6d95e3
https://pubmed.ncbi.nlm.nih.gov/35320356
https://pubmed.ncbi.nlm.nih.gov/35320356
Autor:
Stephan Beck, Miljana Tanic, Andrew Feber, Pawan Dhami, James E. Barrett, John Ambrose, Heli Vaikkinen, Ismail Moghul, Simon Rodney
DNA methylation is a key epigenetic modification in the regulation of cell fate and differentiation, and its analysis is gaining increasing importance in both basic and clinical research. Targeted Bisulfite Sequencing (TBS) has become the method of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e0ebbdb93620dcefdb9ae745422bd2
https://doi.org/10.21203/rs.3.rs-882163/v1
https://doi.org/10.21203/rs.3.rs-882163/v1
Autor:
Francisco Gimeno-Valiente, Carla Castignani, Elizabeth Larose-Cadieux, Kezhong Chen, Nana Mensah, Olga Chervova, Thomas Watkins, Pawan Dhami, Heli Vaikkinen, Andrew Feber, TRACERx Consortium, Jonas Demeulemeester, Miljana Tanic, Stephan Beck, Peter Van Loo, Charles Swanton, Nnennaya Kanu
Publikováno v:
Cancer Research. 82:5710-5710
Introduction: Lung TRACERx is a prominent study employing multi-region and longitudinal multi-omics sequencing to unravel the evolutionary trajectories of lung cancer. Aberrant DNA methylation patterns have been widely described in nearly all human c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30b6f786d51c65da6f96aa1363d43c8e
https://doi.org/10.1158/1538-7445.am2022-5710
https://doi.org/10.1158/1538-7445.am2022-5710