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Akademický článek

Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue

Autor: Inês Félix, Heli Jokela, Joonas Karhula, Noora Kotaja, Eriika Savontaus, Marko Salmi, Pia Rantakari

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Adipose tissue macrophages (ATMs) regulate homeostasis and contribute to the metabolically harmful chronic inflammation in obese individuals. While evident heterogeneity of resident ATMs has been described previously, their phenotype, developmental o

Externí odkaz: https://doaj.org/article/072af540b4f9485f860ad23c02456dff

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Fetal-derived macrophages persist and sequentially maturate in ovaries after birth in mice

Autor: Emmi Lokka, Pia Rantakari, Heli Jokela, Sofia Tyystjärvi, Heidi Gerke, Marko Salmi, Miikka Kiviranta, Kati Elima

Publikováno v: European journal of immunologyReferences. 50(10)

Macrophages, which are highly diverse in different tissues, play a complex and vital role in tissue development, homeostasis, and inflammation. The origin and heterogeneity of tissue-resident monocytes and macrophages in ovaries remains unknown. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ecc81d9458f2e45a359c5870f349c2
https://pubmed.ncbi.nlm.nih.gov/32459864

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Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility

Autor: Janne, Hakkarainen, Fu-Ping, Zhang, Heli, Jokela, Artur, Mayerhofer, Rüdiger, Behr, Sheyla, Cisneros-Montalvo, Mirja, Nurmio, Jorma, Toppari, Claes, Ohlsson, Noora, Kotaja, Petra, Sipilä, Matti, Poutanen

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(6)

The pituitary gonadotrophins and testosterone are the main hormonal regulators of spermatogenesis, but estradiol is also known to play a role in the process. The hormonal responses in the testis are partially mediated by somatic Sertoli cells that pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::07117cf78581f358c427ac676edc4bfb
https://pubmed.ncbi.nlm.nih.gov/31180283

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Hydroxysteroid (17β)-dehydrogenase 1–deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production

Autor: Claes Ohlsson, Fu-Ping Zhang, Matti Poutanen, Heli Jokela, Liesbeth Vandenput, Pirjo Pakarinen, Laura Kätkänaho, Janne Hakkarainen, Hanna Heikelä

Publikováno v: The FASEB Journal. 29:3806-3816

Hydroxysteroid (17β)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to highly active 17-hydroxysteroids, testosterone (T) and E2, respectively. In this study, the imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4e22904ab5946c98df4e1609bf35fc
https://doi.org/10.1096/fj.14-269035

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Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice

Autor: Matti Poutanen, Robert Winqvist, Kirsi Sainio, Katri Pylkäs, Roxana Ola, Pia Rantakari, Heli Jokela, Heidi Lagerbohm, Jenni Nikkilä

Publikováno v: Human Molecular Genetics. 19:3021-3029

Mutations of the PALB2 tumor suppressor gene in humans are associated with hereditary predisposition to breast and also some other cancers. In the present study, we have characterized mice deficient in Palb2. The data show that the Palb2((+/-)) mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b6abcd62f17d0f3c7689ce4ffe7b56
https://doi.org/10.1093/hmg/ddq207

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Hydroxysteroid (17β) Dehydrogenase 7 Activity Is Essential for Fetal de Novo Cholesterol Synthesis and for Neuroectodermal Survival and Cardiovascular Differentiation in Early Mouse Embryos

Autor: Aino-Liisa Mutka, Leena Strauss, Matti Poutanen, Pia Rantakari, Tatu A. Miettinen, Roxana Ola, Heli Jokela, Helena Gylling, Tarja Lamminen, Pirjo Pakarinen, Kirsi Sainio

Publikováno v: Endocrinology. 151:1884-1892

Hydroxysteroid (17β) dehydrogenase 7 (HSD17B7) has been shown to catalyze the conversion of both estrone to estradiol (17-ketosteroid reductase activity) and zymosterone to zymosterol (3-ketosteroid reductase activity involved in cholesterol biosynt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc88339356eb2a2a5a3c738455ff533
https://doi.org/10.1210/en.2009-0928

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Novel hydroxysteroid (17beta) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice

Autor: Tarja Lamminen, Roberto Dina, Päivi Järvensivu, Jan J. Brosens, Antti Perheentupa, Heli Jokela, Pasi Koskimies, Sadaf Ghaem-Maghami, Matti Poutanen, Sari Mäkelä, Taija Saloniemi, Pauliina Damdimopoulou, Harry Kujari

Publikováno v: The American journal of pathology. 176(3)

Local estrogen production plays a key role in proliferative endometrial disorders, such as endometrial hyperplasia and cancer. Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is an enzyme that catalyzes with high efficiency the conversion of weakly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7537f9022aaa07849fe63f0deb84400
https://pubmed.ncbi.nlm.nih.gov/20093485

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