Zobrazeno 1 - 10
of 420
pro vyhledávání: '"Helge Karch"'
Autor:
Nadine Legros, Gottfried Pohlentz, Daniel Steil, Ivan U. Kouzel, Ivan Liashkovich, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 8, Pp 1383-1401 (2018)
Shiga toxins (Stxs) are the major virulence factors of Stx-producing Escherichia coli (STEC), which cause hemorrhagic colitis and severe extraintestinal complications due to injury of renal endothelial cells, resulting in kidney failure. Since kidney
Externí odkaz:
https://doaj.org/article/80ae21502f744401be4a43c7f010311a
Autor:
Lucia Karnisova, Monika Marejkova, Hana Hrbackova, Alexander Mellmann, Helge Karch, Angelika Fruth, Pavel Drevinek, Kveta Blahova, Martina Bielaszewska, Jaroslav Nunvar
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Enterohemorrhagic Escherichia coli (EHEC) O26:H11/H−, the most common non-O157 serotype causing hemolytic uremic syndrome worldwide, are evolutionarily highly dynamic with new pathogenic clones emerging rapidly. Here, we investi
Externí odkaz:
https://doaj.org/article/ff292ad9a6894a99a347e780c8802e20
Autor:
Johanna Detzner, Anna-Lena Klein, Gottfried Pohlentz, Elisabeth Krojnewski, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
Toxins, Vol 13, Iss 8, p 529 (2021)
Tubular epithelial cells of the human kidney are considered as targets of Shiga toxins (Stxs) in the Stx-mediated pathogenesis of hemolytic–uremic syndrome (HUS) caused by Stx-releasing enterohemorrhagic Escherichia coli (EHEC). Analysis of Stx-bin
Externí odkaz:
https://doaj.org/article/4ab3f642e38242558cedb74ca51b35a7
Autor:
Johanna Detzner, Elisabeth Krojnewski, Gottfried Pohlentz, Daniel Steil, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
Toxins, Vol 13, Iss 2, p 139 (2021)
Human kidney epithelial cells are supposed to be directly involved in the pathogenesis of the hemolytic–uremic syndrome (HUS) caused by Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC). The characterization of the major and min
Externí odkaz:
https://doaj.org/article/7307a806e6dc468ea874324d78fd7d7b
Autor:
Daniel Steil, Catherine-Louise Schepers, Gottfried Pohlentz, Nadine Legros, Jana Runde, Hans-Ulrich Humpf, Helge Karch, Johannes Müthing
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2322-2336 (2015)
Shiga toxins (Stxs) are produced by enterohemorrhagic Escherichia coli (EHEC), which cause human infections with an often fatal outcome. Vero cell lines, derived from African green monkey kidney, represent the gold standard for determining the cytoto
Externí odkaz:
https://doaj.org/article/9ccc2feecab542dd8e39a80a9b893a63
Autor:
Alexander Kehl, Ronja Kuhn, Johanna Detzner, Daniel Steil, Johannes Müthing, Helge Karch, Alexander Mellmann
Publikováno v:
Microorganisms, Vol 8, Iss 5, p 673 (2020)
Enterohemorrhagic Escherichia coli (EHEC) is a zoonotic pathogen responsible for life-threating diseases such as hemolytic uremic syndrome. While its major virulence factor, the Shiga toxin (Stx), is known to exert its cytotoxic effect on various end
Externí odkaz:
https://doaj.org/article/4901aa269d754c44aeb34d8c261c7a7c
Autor:
Martina Bielaszewska, Christian Rüter, Andreas Bauwens, Lilo Greune, Kevin-André Jarosch, Daniel Steil, Wenlan Zhang, Xiaohua He, Roland Lloubes, Angelika Fruth, Kwang Sik Kim, M Alexander Schmidt, Ulrich Dobrindt, Alexander Mellmann, Helge Karch
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006159 (2017)
Outer membrane vesicles (OMVs) are important tools in bacterial virulence but their role in the pathogenesis of infections caused by enterohemorrhagic Escherichia coli (EHEC) O157, the leading cause of life-threatening hemolytic uremic syndrome, is p
Externí odkaz:
https://doaj.org/article/df438c3e4bf348ff83104b5fd6a6472e
Autor:
Martina Bielaszewska, Roswitha Schiller, Lydia Lammers, Andreas Bauwens, Angelika Fruth, Barbara Middendorf, M Alexander Schmidt, Phillip I Tarr, Ulrich Dobrindt, Helge Karch, Alexander Mellmann
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 3, Pp 347-357 (2014)
Abstract Extraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non‐pathogens acquire virulence tr
Externí odkaz:
https://doaj.org/article/bfe514cde49048e19795156d2bd858ec
Autor:
Johanna Detzner, Caroline Gloerfeld, Gottfried Pohlentz, Nadine Legros, Hans-Ulrich Humpf, Alexander Mellmann, Helge Karch, Johannes Müthing
Publikováno v:
Microorganisms, Vol 7, Iss 11, p 582 (2019)
Shiga toxin (Stx) producing Escherichia coli (STEC) cause the edema disease in pigs by releasing the swine-pathogenic Stx2e subtype as the key virulence factor. Stx2e targets endothelial cells of animal organs including the kidney harboring the Stx r
Externí odkaz:
https://doaj.org/article/ff5de9bec8e44242820f19984b82b7ec
Autor:
Ivan U. Kouzel, Gottfried Pohlentz, Wiebke Storck, Lena Radamm, Petra Hoffmann, Martina Bielaszewska, Andreas Bauwens, Christoph Cichon, M. Alexander Schmidt, Michael Mormann, Helge Karch, Johannes Müthing
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 692-710 (2013)
Glycosphingolipids (GSLs) of the globo-series constitute specific receptors for Shiga toxins (Stxs) released by certain types of pathogenic Escherichia coli strains. Stx-loaded leukocytes may act as transporter cells in the blood and transfer the tox
Externí odkaz:
https://doaj.org/article/f0ee7e7f5d234e4fb0530775ecb68d87