Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Helge K. Martens"'
Autor:
Martin Dichgans, Andreas Trinkl, Helge K. Martens, Gerhard F. Hamann, Jan Burk, Dorothe Burggraf
Publikováno v:
Brain Research. 1189:189-197
The alpha1-integrin cell adhesion molecules, the principal endothelial receptors for basal lamina (BL) components disappear during transient ischemia. The current study investigated the localization of integrins, the time dependency and vessel size s
Autor:
Martin Liebetrau, Dorothe Burggraf, Gerhard F. Hamann, Helge K. Martens, Gabriele Jäger, Nathalie Wunderlich, Martin Dichgans
Publikováno v:
European Journal of Neuroscience. 22:273-277
Focal cerebral ischemia leads to the gradual disruption of the extracellular matrix. A key role in the turnover of the extracellular matrix is played by the system of matrix metalloproteinases (MMPs). In this study we describe changes of the MMP indu
Publikováno v:
European Journal of Neuroscience. 20:2903-2908
The aim of this study was to investigate the effects of different doses of exogenous recombinant human tissue plasminogen activator (rt-PA) on the endogenous cerebral plasminogen-plasmin system in focal ischemia in rats. Ischemia was induced using th
Publikováno v:
Neuroscience Letters. 357:17-20
Calpains, intracellular proteases, are involved in various cerebral disorders. To determine the effect of moderate hypothermia on calpain activity, transient middle cerebral artery occlusion in rats was performed. For the reperfusion period normother
Publikováno v:
Thrombosis and Haemostasis. 89:1072-1080
SummaryWhile recombinant tissue plasminogen activator (rt-PA) is successfully used in human ischemic stroke, it may also cause hemorrhagic complications. Animal experiments have shown that hemorrhages are related to microvascular basal lamina damage.
Autor:
Martin Liebetrau, Christian U.A. Kloss, Gerhard F. Hamann, G. Bültemeier, Natalie Wunderlich, Gabriele Jäger, Dorothe Burggraf, Thomas Pfefferkorn, Helge K. Martens
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 22:526-533
To define the location and extent of microvascular damage of the basal lamina after cerebral ischemia and reperfusion in rats, the authors subjected animals (n = 16) to 3 hours of focal cerebral ischemia and 24 hours of reperfusion using the suture m
Publikováno v:
Thrombosis and haemostasis. 98(5)
SummaryAlthough recombinant tissue plasminogen activator (rt-PA) is successfully used for thrombolysis in human stroke, it may increase the risk of haemorrhagic complications. It was shown that the matrix metalloproteinase (MMP) system is critically
Publikováno v:
Brain research. 1164
While recombinant tissue plasminogen activator (rt-PA) is successfully used for thrombolysis in human stroke, it may increase the risk of hemorrhagic complications. We describe the effects of different doses of rt-PA (saline, 0.9, 9, or 18 mg rt-PA/k
Autor:
Gerhard F. Hamann, Nora Thomassen, Dorothe Burggraf, Wolfgang Lubisch, Helge K. Martens, Achim Möller, Martin Liebetrau, Dusica Gabrijelcic-Geiger
Publikováno v:
Neurological research. 27(5)
Calpains are intracellular proteases, which are activated in various cerebral injuries. We studied the expression of mu-calpain in a model of focal cerebral ischemia/reperfusion and the efficacy of the calpain inhibitor A-558693.A transient occlusion
Autor:
Martin Dichgans, Martin Liebetrau, Gerhard F. Hamann, Dorothe Burggraf, Helge K. Martens, Milan R. Vosko
Publikováno v:
Neuroscience letters. 386(2)
We describe a novel experimental set-up that allows biochemical, immunohistochemical and morphometric recording of multiple parameters from a single rat brain. The whole brain was cut (coronal sectioning) in a volumetric manner, and 100 cryo-sections