Hemodynamic Effects of Cyclic Guanosine Monophosphate-Dependent Signaling Through β3 Adrenoceptor Stimulation in Patients With Advanced Heart Failure: A Randomized Invasive Clinical Trial

Autor: Henning Bundgaard, Anna Axelsson Raja, Kasper Iversen, Nana Valeur, Niels Tønder, Morten Schou, Alex Hørby Christensen, Niels Eske Bruun, Helle Søholm, Muzhda Ghanizada, Natasha A.S. Fry, Elisha J. Hamilton, Søren Boesgaard, Mathias B. Møller, Emil Wolsk, Kasper Rossing, Lars Køber, Helge H. Rasmussen, Christoffer Rasmus Vissing

Publikováno v: Circulation: Heart Failure. 15

Background: β3-AR (β3-adrenergic receptor) stimulation improved systolic function in a sheep model of systolic heart failure (heart failure with reduced ejection fraction [HFrEF]). Exploratory findings in patients with New York Heart Association fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763580cbe3edbfa18b72f2dea0a74121
https://doi.org/10.1161/circheartfailure.121.009120

Displacement of Native FXYD Protein From Na+/K+-ATPase With Novel FXYD Peptide Derivatives:Effects on Doxorubicin Cytotoxicity

Autor: Chia-Chi Liu, Yeon Jae Kim, Rachel Teh, Alvaro Garcia, Elisha J. Hamilton, Flemming Cornelius, Robert C. Baxter, Helge H. Rasmussen

Publikováno v: Liu, C C, Kim, Y J, Teh, R, Garcia, A, Hamilton, E J, Cornelius, F, Baxter, R C & Rasmussen, H H 2022, ' Displacement of Native FXYD Protein From Na + /K +-ATPase With Novel FXYD Peptide Derivatives : Effects on Doxorubicin Cytotoxicity ', Frontiers in Oncology, vol. 12, 859216 . https://doi.org/10.3389/fonc.2022.859216

The seven mammalian FXYD proteins associate closely with α/β heterodimers of Na+/K+-ATPase. Most of them protect the β1 subunit against glutathionylation, an oxidative modification that destabilizes the heterodimer and inhibits Na+/K+-ATPase activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e916bc51e8a7717ddc5962711b6c83
https://pure.au.dk/portal/da/publications/displacement-of-native-fxyd-protein-from-nakatpase-with-novel-fxyd-peptide-derivatives(74a9a0a3-e211-402f-afd7-710536ae648a).html

Targeting Cardiac Myocyte Na

Autor: Natasha A S, Fry, Chia-Chi, Liu, Alvaro, Garcia, Elisha J, Hamilton, Keyvan, Karimi Galougahi, Yeon Jae, Kim, David W, Whalley, Henning, Bundgaard, Helge H, Rasmussen

Publikováno v: Circulation. Heart failure. 13(9)

Abnormally high cytosolic NaIndices for HF were lung-, heart-, and liver: body weight ratios and ascites after circumflex coronary artery ligation in rabbits. NaCoronary ligation caused ascites in most rabbits, significantly increased lung-, heart-,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5cd5ddcc64e12b81a4352eb97096941
https://pubmed.ncbi.nlm.nih.gov/32842758

P-004. A novel use of β3 adrenergic receptor agonist in treating preeclampsia

Autor: Annemarie Hennessy, Helge H. Rasmussen, YunJia Zhang, Chia-Chi Liu, Angela Makris

Publikováno v: Pregnancy Hypertension. 25:e30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::226b0bbb82dd30fd01320f013875fe7d
https://doi.org/10.1016/j.preghy.2021.07.039

The first-in-man randomized trial of a beta3 adrenoceptor agonist in chronic heart failure: the BEAT-HF trial

Autor: Søren Boesgaard, J. H. Thomsen, Lars Køber, Anna Axelsson, Helge H. Rasmussen, N. Fry, Finn Gustafsson, Henning Bundgaard, Rasmus Bo Hasselbalch, Kasper Iversen, Nana Valeur, Klaus F. Kofoed, Mathias Sørgaard

Publikováno v: European Journal of Heart Failure. 19:566-575

AIMS The third isotype of beta adrenergic receptors (β3 ARs) has distinctly different effects on cardiomyocytes compared with β1 and β2 ARs. Stimulation of β3 ARs may reduce cardiomyocyte Na+ overload and reduce oxidative stress in heart failure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89a857086c80dc07d06a418c9fefc17a
https://doi.org/10.1002/ejhf.714