Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Helga Weber"'
Autor:
Javiera Obreque, Luis Vergara-Gómez, Nicolás Venegas, Helga Weber, Gareth I. Owen, Pablo Pérez-Moreno, Pamela Leal, Juan Carlos Roa, Carolina Bizama
Publikováno v:
Biological Research, Vol 56, Iss 1, Pp 1-27 (2023)
Abstract In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before clinical evaluation, a declaration that now demands the establishment and verification of ex vivo
Externí odkaz:
https://doaj.org/article/53e2cfa4a35d4a9fae6d1f662c519da0
Autor:
Daniela León, María Elena Reyes, Helga Weber, Álvaro Gutiérrez, Claudio Tapia, Ramón Silva, Tamara Viscarra, Kurt Buchegger, Carmen Ili, Priscilla Brebi
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8683 (2024)
Photodynamic therapy (PDT) treats nonmelanoma skin cancer. PDT kills cells through reactive oxygen species (ROS), generated by interaction among cellular O2, photosensitizer and specific light. Protoporphyrin IX (PpIX) is a photosensitizer produced f
Externí odkaz:
https://doaj.org/article/b59581e899084bd594689713d328b2ba
Autor:
Brian Effer, Isabela Perez, Daniel Ulloa, Carolyn Mayer, Francisca Muñoz, Diego Bustos, Claudio Rojas, Carlos Manterola, Luis Vergara-Gómez, Camila Dappolonnio, Helga Weber, Pamela Leal
Publikováno v:
Biomedicines, Vol 11, Iss 7, p 2086 (2023)
Cancer is one of the leading global causes of death and disease, and treatment options are constantly evolving. In this sense, the use of monoclonal antibodies (mAbs) in immunotherapy has been considered a fundamental aspect of modern cancer therapy.
Externí odkaz:
https://doaj.org/article/212def7bb1854f7cb700ec0d9b8be2eb
Autor:
Luis Vergara-Gómez, Carolina Bizama, Jun Zhong, Kurt Buchegger, Felipe Suárez, Lorena Rosa, Carmen Ili, Helga Weber, Javiera Obreque, Karena Espinoza, Gabriela Repetto, Juan C. Roa, Pamela Leal, Patricia García
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7238 (2023)
Treatment options for advanced gallbladder cancer (GBC) are scarce and usually rely on cytotoxic chemotherapy, but the effectiveness of any regimen is limited and recurrence rates are high. Here, we investigated the molecular mechanisms of acquired r
Externí odkaz:
https://doaj.org/article/f85b56d5790f4420afe4ac658218f7ba
Autor:
Patricia García, Carolina Bizama, Lorena Rosa, Jaime A. Espinoza, Helga Weber, Javier Cerda-Infante, Marianela Sánchez, Viviana P. Montecinos, Justo Lorenzo-Bermejo, Felix Boekstegers, Marcela Dávila-López, Francisca Alfaro, Claudia Leiva-Acevedo, Zasha Parra, Diego Romero, Sumie Kato, Pamela Leal, Marcela Lagos, Juan Carlos Roa
Publikováno v:
Biological Research, Vol 53, Iss 1, Pp 1-17 (2020)
Abstract Background Gallbladder cancer (GBC) is the most common tumor of the biliary tract. The incidence of GBC shows a large geographic variability, being particularly frequent in Native American populations. In Chile, GBC represents the second cau
Externí odkaz:
https://doaj.org/article/a26547339f234670bf41ee3ee9f7bab1
Autor:
María José Contreras, Kattia Núñez-Montero, Pablo Bruna, Matías García, Karla Leal, Leticia Barrientos, Helga Weber
Publikováno v:
Antibiotics, Vol 11, Iss 12, p 1796 (2022)
Porcine breeding today is based on artificial insemination with chilled semen. This is stored at 5 °C with antibiotic supplementation to avoid bacteriospermia. There are many negative consequences on sperm quality and functionality as a result of ba
Externí odkaz:
https://doaj.org/article/7485bbd42b6d4e61a1c2d2070c53a254
Autor:
Dina Guzmán-Oyarzo, Jacobo Hernández-Montelongo, Carlos Rosas, Pamela Leal, Helga Weber, Marysol Alvear, Luis A. Salazar
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 484 (2022)
Although polyphenols have great pharmacological potential, the main disadvantage is that they have low bioavailability at the desired site. Thus, the use of biocompatible systems for drug delivery is a strategy that is currently gaining great interes
Externí odkaz:
https://doaj.org/article/8814b9d7de0740048212286de7c0f334
Autor:
Benjamín Durán-Vinet, Karla Araya-Castro, Juan Calderón, Luis Vergara, Helga Weber, Javier Retamales, Paulina Araya-Castro, Pamela Leal-Rojas
Publikováno v:
Cancers, Vol 13, Iss 18, p 4640 (2021)
Colorectal cancer (CRC) is the third most prevalent cancer with the second highest mortality rate worldwide. CRC is a heterogenous disease with multiple risk factors associated, including obesity, smoking, and use of alcohol. Of total CRC cases, 60%
Externí odkaz:
https://doaj.org/article/9ff02e0f037d4cfeb47f1b1c620a9854
Autor:
Patricia García, Lorena Rosa, Sergio Vargas, Helga Weber, Jaime A. Espinoza, Felipe Suárez, Isabel Romero-Calvo, Nicole Elgueta, Vanessa Rivera, Bruno Nervi, Javiera Obreque, Pamela Leal, Eduardo Viñuela, Gloria Aguayo, Sabrina Muñiz, Alfredo Sagredo, Juan C. Roa, Carolina Bizama
Publikováno v:
Cancers, Vol 12, Iss 4, p 778 (2020)
Gallbladder cancer is an aggressive disease with late diagnosis and no efficacious treatment. The Hippo-Yes-associated protein 1 (YAP1) signaling pathway has emerged as a target for the development of new therapeutic interventions in cancers. However
Externí odkaz:
https://doaj.org/article/898804c455bb48d8841a6bf5abbe58f0
Autor:
Helga Weber, Stefan Wunderle
Publikováno v:
Remote Sensing, Vol 11, Iss 4, p 467 (2019)
Explicit knowledge of different error sources in long-term climate records from space is required to understand and mitigate their impacts on resulting time series. Imagery of the heritage Advanced Very High Resolution Radiometer (AVHRR) provides uni
Externí odkaz:
https://doaj.org/article/00f0ad417c1448fca9f53e3e28807e4e