Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Helga U. van der Heul"'
Autor:
Somayah S. Elsayed, Helga U. van der Heul, Xiansha Xiao, Aleksi Nuutila, Laura R. Baars, Changsheng Wu, Mikko Metsä-Ketelä, Gilles P. van Wezel
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-16 (2023)
Abstract Angucyclines are type II polyketide natural products, often characterized by unusual structural rearrangements through B- or C-ring cleavage of their tetracyclic backbone. While the enzymes involved in B-ring cleavage have been extensively s
Externí odkaz:
https://doaj.org/article/552e4cdb804544a5861a5f3671f524ed
Autor:
Mandy B. Hulst, Le Zhang, Helga U. van der Heul, Chao Du, Somayah S. Elsayed, Arina Koroleva, Thadee Grocholski, Dennis P. A. Wander, Mikko Metsä-Ketelä, Jacques J. C. Neefjes, Gilles P. van Wezel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction: Daunorubicin and doxorubicin, two anthracycline polyketides produced by S. peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of prod
Externí odkaz:
https://doaj.org/article/4df9c2d97b6a46d0a40d7261af1249f7
Autor:
Changsheng Wu, Gilles P. van Wezel, Pieter C. Dorrestein, Jens Lübben, Helga U. van der Heul, Adriaan J. Minnaard, Young Hae Choi, Alexey V. Melnik
Publikováno v:
Angewandte Chemie (International ed. in English), 58(9), 2809-2814
Angewandte Chemie-International Edition, 58(9), 2809-2814. WILEY-V C H VERLAG GMBH
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 58(9), 2809-2814. WILEY-V C H VERLAG GMBH
Angewandte Chemie (International Ed. in English)
The angucyclines form the largest family of polycyclic aromatic polyketides, and have been studied extensively. Herein, we report the discovery of lugdunomycin, an angucycline‐derived polyketide, produced by Streptomyces species QL37. Lugdunomycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a8aab88b03fe6cc6cd98dd3b53a838
https://doi.org/10.1002/anie.201814581
https://doi.org/10.1002/anie.201814581
Autor:
Silvia Estevão, Helga U van der Heul, Marcel Sluijter, Theo Hoogenboezem, Nico G Hartwig, Annemarie M C van Rossum, Cornelis Vink
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70870 (2013)
The DNA recombination and repair machinery of Mycoplasma pneumoniae is composed of a limited set of approximately 11 proteins. Two of these proteins were predicted to be encoded by neighboring open reading frames (ORFs) MPN340 and MPN341. Both ORFs w
Externí odkaz:
https://doaj.org/article/ef180c4eb0e748388851a9de4cef3f35
Autor:
Gilles P. van Wezel, Helga U. van der Heul, Michiel T. Uiterweerd, Isabel Nunez Santiago, Adriaan J. Minnaard
Publikováno v:
European Journal of Organic Chemistry, 2020(32), 5145-5152. WILEY-V C H VERLAG GMBH
European Journal of Organic Chemistry, 5145-5152
ISSUE=32;STARTPAGE=5145;ENDPAGE=5152;TITLE=European Journal of Organic Chemistry
European Journal of Organic Chemistry, 5145-5152
ISSUE=32;STARTPAGE=5145;ENDPAGE=5152;TITLE=European Journal of Organic Chemistry
Iso-maleimycin, a previously unknown constitutional isomer of the antibiotic maleimycin, has been detected in an extract of Streptomyces sp. QL37. Chemical synthesis of both maleimycin (20 % yield over seven steps) and iso-maleimycin, (15 % yield ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe4335cfca18729e85f8ea54c543698
https://research.rug.nl/en/publications/6f4b5a7d-1aab-48d5-b950-6c176ebd3f52
https://research.rug.nl/en/publications/6f4b5a7d-1aab-48d5-b950-6c176ebd3f52
Autor:
Changsheng Wu, Andrea E. Prota, Helga U. van der Heul, Chao Du, Xiansha Xiao, Weidong Liu, Mikko Metsä-Ketelä, Chun-Chi Chen, Rey-Ting Guo, Somayah S. Elsayed, Jan Pieter Abrahams, Gilles P. van Wezel
Publikováno v:
ACS Chemical Biology, 15(9), 2529-2538
ACS Chemical Biology
ACS Chemical Biology
Angucyclines are a structurally diverse class of actinobacterial natural products defined by their varied polycyclic ring systems, which display a wide range of biological activities. We recently discovered lugdunomycin (1), a highly rearranged polyk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8fee26a0f5dd1336b75ddf16474bfb
http://hdl.handle.net/1887/3134616
http://hdl.handle.net/1887/3134616
Autor:
Gilles P. van Wezel, Bohdan Bilyk, Ryan F. Seipke, Helga U. van der Heul, Kenneth J. McDowall
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that inhabit both soil and aquatic sediments. In the natural environment, antimicr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272327463965bb9308189ca43ce0188a
https://eprints.whiterose.ac.uk/130173/1/NaturalProductsReports_April.pdf
https://eprints.whiterose.ac.uk/130173/1/NaturalProductsReports_April.pdf