Interplay between Caveolin-1 and body and tumor size affects clinical outcomes in breast cancer

Autor: Christopher Godina, Vineesh Indira Chandran, Magdalena Barbachowska, Helga Tryggvadottir, Björn Nodin, Edward Visse, Signe Borgquist, Karin Jirström, Karolin Isaksson, Ana Bosch, Mattias Belting, Helena Jernström

Publikováno v: Translational Oncology, Vol 22, Iss , Pp 101464- (2022)

Background: Caveolin-1 (CAV1) is associated with cholesterol-rich membrane raft domains and is a master regulator of cell signaling and membrane transport. Here, we investigated CAV1’s role in cellular compartments of breast cancer in relation to s

Externí odkaz: https://doaj.org/article/d9798d3b49bb4a7c89a22c3134b4a34a

The Prognostic Impact of Intratumoral Aryl Hydrocarbon Receptor in Primary Breast Cancer Depends on the Type of Endocrine Therapy: A Population-Based Cohort Study

Autor: Helga Tryggvadottir, Emma Sandén, Sofie Björner, Alessandra Bressan, Maria Ygland Rödström, Somayeh Khazaei, Dean P. Edwards, Björn Nodin, Karin Jirström, Karolin Isaksson, Signe Borgquist, Helena Jernström

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

The aryl hydrocarbon receptor (AhR) is a master regulator of multiple pathways involved in breast cancer, and influences the estrogen receptor alpha (ER) and aromatase/CYP19A1. The purpose of this study was to elucidate the interplay between intratum

Externí odkaz: https://doaj.org/article/1a080f780df64b5cb7c55bdd4e05c12e

Prognostic Impact of Menopausal Hormone Therapy in Breast Cancer Differs According to Tumor Characteristics and Treatment

Autor: Christopher Godina, Erik Ottander, Helga Tryggvadottir, Signe Borgquist, Karolin Isaksson, Helena Jernström

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

This study investigated how a history of menopausal hormone therapy (MHT) impacts clinical outcomes overall and in different subgroups of breast cancer patients. The study included 814 primary breast cancer patients aged ≥50 years in Sweden (2002�

Externí odkaz: https://doaj.org/article/378227b51b54441f937e5d29ba8d8cf2

Coffee Is Associated With Lower Breast Tumor Insulin-Like Growth Factor Receptor 1 Levels in Normal-Weight Patients and Improved Prognosis Following Tamoxifen or Radiotherapy Treatment

Autor: Sofie Björner, Ann H. Rosendahl, Helga Tryggvadottir, Maria Simonsson, Karin Jirström, Signe Borgquist, Carsten Rose, Christian Ingvar, Helena Jernström

Publikováno v: Frontiers in Endocrinology, Vol 9 (2018)

Coffee is associated with decreased breast cancer risk, but the impact of body mass index (BMI) in combination with coffee consumption on prognosis is unclear. The suppressive effect of coffee constituents on the insulin-like growth factor receptor 1

Externí odkaz: https://doaj.org/article/859bfe1334084ca291dca1d8ac4638dd

Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer: a prospective cohort study

Autor: Somayeh Khazaei, Ana Bosch, Helena Jernström, Christopher Godina, Edward Visse, Karolin Isaksson, Helga Tryggvadottir, Karin Jirström, Björn Nodin, Signe Borgquist

Publikováno v: Godina, C, Khazaei, S, Tryggvadottir, H, Visse, E, Nodin, B, Jirström, K, Borgquist, S, Bosch, A, Isaksson, K & Jernström, H 2021, ' Prognostic impact of tumor-specific insulin-like growth factor binding protein 7 (IGFBP7) levels in breast cancer : A prospective cohort study ', Carcinogenesis, vol. 42, no. 11, pp. 1314-1325 . https://doi.org/10.1093/carcin/bgab090
Carcinogenesis

The prognostic impact of insulin-like growth factor binding protein 7 (IGFBP7) in breast cancer is unclear. Host factors, including lifestyle, anthropometry and metabolic profile, might influence tumor-specific IGFBP7. This study aimed to investigate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ccc7b49b753aaace2171e6a33b905d5
https://doi.org/10.1093/carcin/bgab090