Výsledky vyhledávání - "Helga Seyschab"

Simultaneous measurement, using flow cytometry, of radiosensitivity and defective mitogen response in ataxia telangiectasia and related syndromes

Autor: J. P. Fryns, Ingeborg Krägeloh-Mann, Folker Hanefeld, E. Seemanova, Helga Seyschab, Gotthold Barbi, Albert Schinzel, Rudolf Korinthenberg, Eugen Boltshauser, N. Tommerup, Holger Hoehn, J. M. J. C. Scheres, Detlev Schindler, Richard Friedl

Publikováno v: European Journal of Pediatrics. 151:756-760

In a retrospective study, peripheral blood mononuclear cells from 13 patients with known ataxia telangiectasia (AT) (Louis Bar syndrome, McKusick #20890) were irradiated with different doses of X-rays prior to stimulation with phytohaemagglutinin. Mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037b2d9fea576cf21f60cdcc3c3dfc5d
https://doi.org/10.1007/bf01959085

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Chromosome instability and X-ray hypersensitivity in a microcephalic and growth-retarded child

Autor: Karl Mehnert, J. M. J. C. Scheres, Klaus Rodens, Detlev Schindler, R. D. F. M. Taalman, Max Müller, Helga Seyschab, Gotthold Barbi

Publikováno v: American Journal of Medical Genetics. 40:44-50

We report on a microcephalic, growth-retarded newborn girl without major anomalies who has chromosome instability in lymphocytes and fibroblasts. Frequent involvement of bands 7p13, 7q34, 14q11, and 14q32 suggested the diagnosis of ataxia telangiecta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb052d4184dee27c1e073ef46487a1a6
https://doi.org/10.1002/ajmg.1320400109

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Comparative evaluation of diepoxybutane sensitivity and cell cycle blockage in the diagnosis of Fanconi anemia

Autor: Traute Schroeder-Kurth, Holger Hoehn, Detlev Schindler, Helga Seyschab, Sabine Hentze, Richard Friedl, Yujie Sun

Publikováno v: Blood. 85(8)

Fanconi anemia (FA) is a clinically and genetically heterogenous disease that is usually diagnosed on the basis of chromosomal instability reflecting the hypersensitivity towards the DNA cross-linking agents diepoxybutane (DEB) and/or mitomycin C. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a1eaf613f961ef3b420febf09b9a8a
https://pubmed.ncbi.nlm.nih.gov/7718895

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Modulation of the spontaneous G2 phase blockage in Fanconi anemia cells by caffeine: differences from cells arrested by X-irradiation

Autor: Holger Hoehn, Gisela Bretzel, Richard Friedl, Helga Seyschab, Detlev Schindler, Yujie Sun

Publikováno v: Mutation research. 308(2)

The effect of caffeine on the endogenous G2 phase cell cycle blockage of Fanconi anemia (FA) cells was compared with the effect of caffeine on the G2 phase blockage induced in control cells by X-irradiation. The G2 phase accumulations in FA cells cou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2479ad766824fe6cf5961932c6679be1
https://pubmed.ncbi.nlm.nih.gov/7518042

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G2 phase cell cycle disturbance as a manifestation of genetic cell damage

Autor: Helga Seyschab, Yujie Sun, Detlev Schindler, Holger Hoehn, Richard Friedl

Publikováno v: Human genetics. 92(1)

The predominant cell cycle change induced by X-rays and clastogens in peripheral blood mononuclear cells is the accumulation of cells in the G2 phase of the cell cycle. We show that this accumulation consists of cells that are either delayed or arres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bb31fd8c7794e4bab390eb70262c37
https://pubmed.ncbi.nlm.nih.gov/8365728

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Differential activity of recombinant lymphokines on mouse B cell proliferation and cell cycle progression are revealed by 5-bromo-2'-deoxyuridine/Hoechst 33258 dye flow cytometry

Autor: Helga Seyschab, Holger Hoehn, Una Chen, Peter S. Rabinovitch

Publikováno v: European journal of immunology. 21(9)

Activation of resting mouse B cells with anti-mu chain antibodies (anti-mu) leads to cell proliferation. We have investigated the effect of recombinant T cell interleukins (IL 2 to IL 6) on such anti-mu-induced proliferation. No proliferative respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30d20db2a8ae0a5606a855f421d4ce3d
https://pubmed.ncbi.nlm.nih.gov/1909644

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Continuous bromodeoxyuridine labeling and bivariate ethidium bromide/hoechst flow cytometry in cell kinetics

Autor: Holger Hoehn, Julia Koehler, U. Kaempf, Peter S. Rabinovitch, Martin Poot, Detlev Schindler, Una Chen, M. Kubbies, Helga Seyschab, Heidi Schmitt

Publikováno v: Cytometry. 10:222-226

Most techniques of flow cytometric cell cycle analysis are not capable of distinguishing the number of rounds of DNA synthesis that a cell has undergone since the start of an experiment. Continuous labeling with 5-bromodeoxyuridine (Brd-Urd) offers s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f56e386bbcd258589220eb09d7ce46
https://doi.org/10.1002/cyto.990100215

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The effects of bacterial lipopolysaccharide, anti-receptor antibodies and recombinant interferon on mouse B cell cycle progression using 5-bromo-2'-deoxyuridine/hoechst 33258 dye flow cytometry

Autor: Holger Hoehn, Richard Friedl, Helga Seyschab, Detlev Schindler, Peter S. Rabinovitch, Una Chen

Publikováno v: European Journal of Immunology. 19:1605-1612

Polyclonal stimulation of resting B cells with anti-antigen receptor antibodies [anti-IgM mu chain antibody (anti-mu)] or with bacterial lipopolysaccharide (LPS) stimulates a proportion of B cells to proliferate. Exposure of resting B cells to both L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88fe081c726bc245e99e7c9fe90c021
https://doi.org/10.1002/eji.1830190913

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