Výsledky vyhledávání - "Helga Kleiner"

Akademický článek

Genotoxic Bystander Signals from Irradiated Human Mesenchymal Stromal Cells Mainly Localize in the 10–100 kDa Fraction of Conditioned Medium

Autor: Vanessa Kohl, Alice Fabarius, Oliver Drews, Miriam Bierbaum, Ahmed Jawhar, Ali Darwich, Christel Weiss, Johanna Flach, Susanne Brendel, Helga Kleiner, Wolfgang Seifarth, Wolf-Karsten Hofmann, Henning D. Popp

Publikováno v: Cells, Vol 10, Iss 4, p 827 (2021)

Genotoxic bystander signals released from irradiated human mesenchymal stromal cells (MSC) may induce radiation-induced bystander effects (RIBEs) in human hematopoietic stem and progenitor cells (HSPC), potentially causing leukemic transformation. Al

Externí odkaz: https://doaj.org/article/324cbdfc921b4985a3e13ddfc358bd33

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Akademický článek

Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.

Autor: Sabrina Ruppenthal, Helga Kleiner, Florian Nolte, Alice Fabarius, Wolf-Karsten Hofmann, Daniel Nowak, Wolfgang Seifarth

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0191734 (2018)

ESPL1/separase, a cysteine endopeptidase, is a key player in centrosome duplication and mitotic sister chromatid separation. Aberrant expression and/or altered separase proteolytic activity are associated with centrosome amplification, aneuploidy, tu

Externí odkaz: https://doaj.org/article/4140e6baeb7e4420bf1b671951f1bd1b

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Akademický článek

Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.

Autor: Wiltrud Haaß, Helga Kleiner, Christel Weiß, Claudia Haferlach, Brigitte Schlegelberger, Martin C Müller, Rüdiger Hehlmann, Wolf-Karsten Hofmann, Alice Fabarius, Wolfgang Seifarth, Schweizerische Arbeitsgemeinschaft für Klinische Krebsforschung, German CML Study Group

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129648 (2015)

Unbalanced (major route) additional cytogenetic aberrations (ACA) at diagnosis of chronic myeloid leukemia (CML) indicate an increased risk of progression and shorter survival. Moreover, newly arising ACA under imatinib treatment and clonal evolution

Externí odkaz: https://doaj.org/article/f121bb6eca144f35b1cf7854cf9ad6dc

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Akademický článek

Measurement of separase proteolytic activity in single living cells by a fluorogenic flow cytometry assay.

Autor: Wiltrud Haaß, Helga Kleiner, Martin C Müller, Wolf-Karsten Hofmann, Alice Fabarius, Wolfgang Seifarth

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0133769 (2015)

ESPL1/Separase, an endopeptidase, is required for centrosome duplication and separation of sister-chromatides in anaphase of mitosis. Overexpression and deregulated proteolytic activity of Separase as frequently observed in human cancers is associate

Externí odkaz: https://doaj.org/article/0ae70782c5b54ec98a47e9f9b5b718c0

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Evidence for recombinant GRP78, CALR, PDIA3 and GPI as mediators of genetic instability in human CD34+ cells

Autor: Alice Fabarius, Vanessa Samra, Oliver Drews, Handan Mörz, Miriam Bierbaum, Ali Darwich, Christel Weiss, Susanne Brendel, Helga Kleiner, Wolfgang Seifarth, Wolfgang Greffrath, Wolf-Karsten Hofmann, Clemens A. Schmitt, Henning D. Popp

Publikováno v: Cancers; Volume 14; Issue 12; Pages: 2883

Soluble factors released from irradiated human mesenchymal stromal cells (MSC) may induce genetic instability in human CD34+ cells, potentially mediating hematologic disorders. Recently, we identified four key proteins in the secretome of X-ray-irrad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0523aa1111fb73ee0403905a9b83bd53
http://edoc.mdc-berlin.de/21720/1/21720oa.pdf

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Gene Expression Pattern of ESPL1, PTTG1 and PTTG1IP Can Potentially Predict Response to TKI First-Line Treatment of Patients with Newly Diagnosed CML

Autor: Eva Christiani, Nicole Naumann, Christel Weiss, Birgit Spiess, Helga Kleiner, Alice Fabarius, Wolf-Karsten Hofmann, Susanne Saussele, Wolfgang Seifarth

Publikováno v: Cancers; Volume 15; Issue 9; Pages: 2652

The achievement of major molecular response (MMR, BCR::ABL1 ≤ 0.1% IS) within the first year of treatment with tyrosine kinase inhibitors (TKI) is a milestone in the therapeutic management of patients with newly diagnosed chronic myeloid leukemia (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437c7da0c1d457a2c54c4fcba57abfb0
https://doi.org/10.3390/cancers15092652

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Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients

Autor: Wolfgang Seifarth, Birgit Spiess, Johanna Flach, Wolf-Karsten Hofmann, Helga Kleiner, Susanne Saussele, Alice Fabarius

Publikováno v: Annals of Hematology. 99:991-1006

Separase, a cysteine endopeptidase, is a key player in mitotic sister chromatid separation, replication fork dynamics, and DNA repair. Aberrant expression and/or altered separase proteolytic activity are associated with aneuploidy, tumorigenesis, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e92b91383690dbc16c9c333947167b3
https://doi.org/10.1007/s00277-020-04007-4

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Proteins Marking the Sequence of Genotoxic Signaling from Irradiated Mesenchymal Stromal Cells to CD34+ Cells

Autor: Vanessa Kohl, Alice Fabarius, Daniel Nowak, Birgit Spiess, Christel Weiss, Henning Roehl, Oliver Drews, Wolf-Karsten Hofmann, Henning D. Popp, Helga Kleiner, Susanne Brendel, Victor Costina, Johanna Flach, Miriam Bierbaum, Ahmed Jawhar, Wolfgang Seifarth

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 5844, p 5844 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 11

Non-targeted effects (NTE) of ionizing radiation may initiate myeloid neoplasms (MN). Here, protein mediators (I) in irradiated human mesenchymal stromal cells (MSC) as the NTE source, (II) in MSC conditioned supernatant and (III) in human bone marro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838a9b0b50a2e78241cf8adbb9bdf0ca
https://www.mdpi.com/1422-0067/22/11/5844

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Irradiated mesenchymal stromal cells induce genetic instability in human CD34+ cells

Autor: Birgit Spiess, Alice Fabarius, Wolf-Karsten Hofmann, Ahmed Jawhar, Miriam Bierbaum, Wolfgang Seifarth, Helga Kleiner, Victor Costina, Susanne Brendel, Vanessa Kohl, Oliver Drews, Johanna Flach, Daniel Nowak, Henning D. Popp, Christel Weiss, Henning Roehl

Radiation-induced bystander effects (RIBE) in human hematopoietic stem and progenitor cells may initiate myeloid neoplasms (MN). Here, the occurrence of RIBE caused by genotoxic signaling from irradiated human mesenchymal stromal cells (MSC) on human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72c3c1239ed273438701f4557fc1196a
https://doi.org/10.1101/2020.10.30.361758

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