Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Helga Gleichmann"'
Autor:
Helga Gleichmann, Patricia Ohly
Publikováno v:
Experimental and Clinical Endocrinology & Diabetes. 103:79-82
Recently, this laboratory reported that the antioxidant metallothionein (MT) is constitutively expressed and significantly (p < 0.001) induced with zinc in pancreatic islets in vivo. Therefore, our aim was to study, whether MT can also be induced in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671337c7417f2ef29195fc2ca445e510
https://doi.org/10.1055/s-0029-1211399
https://doi.org/10.1055/s-0029-1211399
Autor:
Friedrich Deerberg, Helga Gleichmann
A report is given on the frequency of immune-complex glomerulonephritis in Han: NMRI mice, on the results from histological examination and from immunofluorescence microscopy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad37a2da9dd86c6ffc318a4dcd3b601f
https://doi.org/10.1159/000428765
https://doi.org/10.1159/000428765
Autor:
Helga Gleichmann, Hans-Joachim Partke, Abdelhakim Lgssiar, Mohamed Hassan, Patricia Schott-Ohly, Nadira Friesen
Publikováno v:
Experimental Biology and Medicine. 229:1177-1185
Recently, we reported that zinc sulfate-enriched (25 mM) drinking water (Zn2+) protected male C57BL/6 mice from diabetes induced by multiple low doses of streptozotocin (MLD-STZ) and that MLD-STZ activates the transcription factors nuclear factor (NF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286da38174c6792b5d854a65964f5383
https://doi.org/10.1177/153537020422901113
https://doi.org/10.1177/153537020422901113
Publikováno v:
Diabetologia. 47:676-685
We studied the impact of the reactive oxygen species hydrogen peroxide (H2O2) and antioxidative enzymes on the pathogenesis of diabetes induced by multiple low doses of streptozotocin (MLD-STZ). We isolated the islets of C57BL/6 mice. For ex vivo ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b783f4c887cc55da8a01651bc9ce94
https://doi.org/10.1007/s00125-004-1367-x
https://doi.org/10.1007/s00125-004-1367-x
Publikováno v:
Life Sciences. 71:1681-1694
Type 1 diabetes results from irreversible damage of insulin-producing beta-cells. In laboratory animals, diabetes can be induced with alloxan (ALX), a 2,4,5,6-tetraoxopyrimidine. ALX is a potent generator of reactive oxygen species (ROS), which can m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077587dd1794039a2d0fa59654162a74
https://doi.org/10.1016/s0024-3205(02)01918-5
https://doi.org/10.1016/s0024-3205(02)01918-5
Autor:
Nadira Friesen, Hans Nohl, Patricia Schott-Ohly, Sabine Schulte im Walde, Lars Gille, Helga Gleichmann, Natascha Udilova
Publikováno v:
Pharmacology & Toxicology. 90:317-326
Type I diabetes is considered a multifactorial autoimmune process initiated by an environmental factor. There is evidence that reactive oxygen species are involved in destructing insulin-producing b-cells. In mice, reactive oxygen species and nitric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38121f234414cb1889b5e098b2dfb2e1
https://doi.org/10.1034/j.1600-0773.2002.900605.x
https://doi.org/10.1034/j.1600-0773.2002.900605.x
Publikováno v:
Immunobiology. 205:35-50
In the nonobese diabetic (NOD) mouse, the T helper (Th)1-type inflammatory cytokines interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha play a critical role in the development of type 1 diabetes, whereas the Th2-type anti-inflammatory cytok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5851b435ef3948a4cf5314d70bfb55ee
https://doi.org/10.1078/0171-2985-00109
https://doi.org/10.1078/0171-2985-00109
Publikováno v:
Immunology today. 5(11)
Parental strain T lymphocytes injected into adult F, mice respond to allogeneic MHC antigens and so induce the symptoms of systemic graft v. host disease (GVHD). GVHD has two forms, stimulatory and suppressive, and in each there are pathological chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a109549c430df850cc3d58faa687b5
https://pubmed.ncbi.nlm.nih.gov/25290757
https://pubmed.ncbi.nlm.nih.gov/25290757
Publikováno v:
Talanta. 46:355-359
In mice, autoimmune diabetes can be induced with multiple low doses of streptozotocin (MLD-STZ). Specific T cell-dependent immune reactions and non-specific inflammatory damage induced by reactive oxygen species (ROS) are involved in the pathogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4c6e74be5cbb50d3f94f8634c9dee6
https://doi.org/10.1016/s0039-9140(97)00347-0
https://doi.org/10.1016/s0039-9140(97)00347-0
Publikováno v:
Journal of Hypertension. 15:S31-S38
Non-insulin-dependent diabetes mellitus (NIDDM) is often associated with hypertension leading to a specifically high cardiovascular risk in these patients. However, there is evidence that insulin resistance and hyperinsulinaemia are not only characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7dc87f51b1066ee10ed5af00ba0717e
https://doi.org/10.1097/00004872-199715011-00004
https://doi.org/10.1097/00004872-199715011-00004