Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Helfrid Hochegger"'
Autor:
Jesús Galán-Vidal, Lorena García-Gaipo, Rut Molinuevo, Samantha Dias, Alex Tsoi, Javier Gómez-Román, James T. Elder, Helfrid Hochegger, Alberto Gandarillas
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-14 (2024)
Abstract Squamous or epidermoid cancer arises in stratified epithelia but also is frequent in the non-epidermoid epithelium of the lung by unclear mechanisms. A poorly studied mitotic checkpoint drives epithelial cells bearing irreparable genetic dam
Externí odkaz:
https://doaj.org/article/95a08db4657e4286ad01687d6e960663
Autor:
Tom Stiff, Fabio R. Echegaray-Iturra, Harry J. Pink, Alex Herbert, Constantino Carlos Reyes-Aldasoro, Helfrid Hochegger
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: Centrosome separation in late G2/ early prophase requires precise spatial coordination that is determined by a balance of forces promoting and antagonizing separation. The major effector of centrosome separation is the kinesin Eg5. However,
Externí odkaz:
https://doaj.org/article/177c8b7689f845c4924f634835331cab
Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis
Autor:
Alexander JR Booth, Zuojun Yue, John K Eykelenboom, Tom Stiff, GW Gant Luxton, Helfrid Hochegger, Tomoyuki U Tanaka
Publikováno v:
eLife, Vol 8 (2019)
To ensure proper segregation during mitosis, chromosomes must be efficiently captured by spindle microtubules and subsequently aligned on the mitotic spindle. The efficacy of chromosome interaction with the spindle can be influenced by how widely chr
Externí odkaz:
https://doaj.org/article/a9c9a5e064a64b0cb1a0e22c0b56dc8a
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
The use of constitutive promoters to drive exogenous protein expression is an important tool for the study of diverse biological processes. To create and characterise a stably integrated expression system for DT40 cells, we constructed integration ca
Externí odkaz:
https://doaj.org/article/9fee5f7859b943cbba43f72c9c078fd2
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
The use of constitutive promoters to drive exogenous protein expression is an important tool for the study of diverse biological processes. To create and characterise a stably integrated expression system for DT40 cells, we constructed integration ca
Externí odkaz:
https://doaj.org/article/435d522787544066886f14a88d7140b9
Publikováno v:
Stem Cell Research, Vol 13, Iss 1, Pp 135-143 (2014)
Glioma stem-cell-like cells are considered to be responsible for treatment resistance and tumour recurrence following chemo-radiation in glioblastoma patients, but specific targets by which to kill the cancer stem cell population remain elusive. A ch
Externí odkaz:
https://doaj.org/article/df5fc42c115a413ab12d6373d3bc1a19
Autor:
Nadia Hégarat, Clare Vesely, P K Vinod, Cory Ocasio, Nisha Peter, Julian Gannon, Antony W Oliver, Béla Novák, Helfrid Hochegger
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004004 (2014)
Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylatio
Externí odkaz:
https://doaj.org/article/a8ec7b573e9743e3938c8cb598895b1e
Publikováno v:
Open Biology, Vol 3, Iss 3 (2013)
The correct assembly and timely disassembly of the mitotic spindle is crucial for the propagation of the genome during cell division. Aurora kinases play a central role in orchestrating bipolar spindle establishment, chromosome alignment and segregat
Externí odkaz:
https://doaj.org/article/5d27400d014547d2801da585dc441aec
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6155 (2009)
BACKGROUND:Cellular contractility, essential for cell movement and proliferation, is regulated by microtubules, RhoA and actomyosin. The RhoA dependent kinase ROCK ensures the phosphorylation of the regulatory Myosin II Light Chain (MLC) Ser19, there
Externí odkaz:
https://doaj.org/article/18f3e1eb60c4451db7c62644c6977cbd
Autor:
Shunichi Takeda, Simon J. Boulton, Helfrid Hochegger, Guang Yu Zhao, Alan Lehmann, Atsuko Niimi, Hiroshi Kimura, Kyoko Yokomori, Weihua Zeng, Louise J. Barber, Eiichiro Sonoda, Yasuhiro Murakawa
Supplementary Figures 1-5 from Inhibitors of the Proteasome Suppress Homologous DNA Recombination in Mammalian Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ecb63e1a18adda933142bd4c4cb69c
https://doi.org/10.1158/0008-5472.22370211
https://doi.org/10.1158/0008-5472.22370211
