Výsledky vyhledávání - "Helene Zinszner"

Identification of novel stress-induced genes downstream of chop

Autor: Masahiko Kuroda, Peter Chung, Nikoleta Batchvarova, Xiaozhong Wang, Robin A. Kimmel, Helene Zinszner, David Ron, John Sok

Publikováno v: The EMBO Journal. 17:3619-3630

CHOP (GADD153) is a small nuclear protein that dimerizes avidly with members of the C/EBP family of transcription factors. Normally undetectable, it is expressed at high levels in cells exposed to conditions that perturb protein folding in the endopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ad914b78d091b02daea9bc06b34eb8
https://doi.org/10.1093/emboj/17.13.3619

Zobrazit plný text záznamu

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

Autor: Joseph W. Brewer, David Ron, Helene Zinszner, Beth Lawson, Gert Kreibich, Li-Jun Mi, Xiaozhong Wang, Linda M. Hendershot, Robert J. Boorstein, Archana Sanjay

Publikováno v: Europe PubMed Central

The gene encoding C/EBP-homologous protein (CHOP), also known as growth arrest and DNA-damage-inducible gene 153 (GADD153), is activated by agents that adversely affect the function of the endoplasmic reticulum (ER). Because of the pleiotropic effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4ef64918dfd94493f3a5196bae5f84
https://doi.org/10.1128/mcb.16.8.4273

Zobrazit plný text záznamu

Altered binding of regulatory factors to HLA class I enhancer sequence in human tumor cell lines lacking class I antigen expression

Autor: Philippe Kourilsky, Pascale Paul, Helene Zinszner, Odile Blanchet, Jean Dausset, Jean-François Bourge, Laurent Degos, Alain Israel

Publikováno v: Proceedings of the National Academy of Sciences. 89:3488-3492

Class I antigens encoded in the major histocompatibility complex (MHC) (HLA in man, H-2 in the mouse) play a key role in the recognition of target cells by cytolytic T lymphocytes. Tumor cells frequently do not express class I MHC molecules, which st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f718110fa87cf0182765c8bf6a379780
https://doi.org/10.1073/pnas.89.8.3488

Zobrazit plný text záznamu

DNA binding of regulatory factors interacting with MHC-class-I gene enhancer correlates with MHC-class-I transcriptional level in class-I-defective cell lines

Autor: Laurent Degos, Helene Zinszner, Pascale Paul, Z. Tatari, Odile Blanchet, Jean-François Bourge

Publikováno v: International Journal of Cancer. 47:138-145

Tumor cells frequently show a lack of surface class-I major histocompatibility complex (MHC) antigen expression. These molecules are key recognition structures for immune rejection of tumor cells and their absence at the surface of tumor cells could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f8486c087062a9d8dd0625f176a95a
https://doi.org/10.1002/ijc.2910470725

Zobrazit plný text záznamu

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

Autor: Nikoleta Batchvarova, James L. Stevens, Richard T. Lightfoot, Helene Zinszner, Masahiko Kuroda, Xiaozhong Wang, Helen Remotti, David Ron

Publikováno v: Genesdevelopment. 12(7)

Cellular stress, particularly in response to toxic and metabolic insults that perturb function of the endoplasmic reticulum (ER stress), is a powerful inducer of the transcription factor CHOP. The role of CHOP in the response of cells to injury assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b28f20df206067945a0a5dbc146ddc
https://pubmed.ncbi.nlm.nih.gov/9531536

Zobrazit plný text záznamu

TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling

Autor: John Sok, Helene Zinszner, David Ron, Yin Yin, David Immanuel

Publikováno v: Europe PubMed Central
Scopus-Elsevier

TLS, the product of a gene commonly translocated in liposarcomas (TLS), is prototypical of a newly identified class of nuclear proteins that contain a C-terminal domain with a distinct RNA recognition motif (RRM) surrounded by Arg-Gly-Gly (RGG) repea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d0b4e46aafe60a1384f7a49ab46a0cc
https://pubmed.ncbi.nlm.nih.gov/9264461

Zobrazit plný text záznamu

A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited

Autor: Helene Zinszner, David Immanuel, David Ron, Yin Yin, Feng-Xia Liang

Publikováno v: Oncogene. 14(4)

TLS (FUS) and the related gene EWS encode the N-terminal portion of many fusion oncoproteins involved in human sarcomas and leukemia. TLS is an RNA-binding nuclear protein that is identical to hnRNP P2 and may be implicated in mRNA metabolism. When R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43816e4c1e476faddba1833833c867f
https://pubmed.ncbi.nlm.nih.gov/9053842

Zobrazit plný text záznamu

Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II

Autor: David Immanuel, Helene Zinszner, David Ron

Publikováno v: Europe PubMed Central

Many oncogenes associated with human sarcomas are composed of a fusion between transcription factors and the N-terminal portions of two similar RNA-binding proteins, TLS and EWS. Though the oncogenic fusion proteins lack the RNA-binding domain and do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44409ce41df09b7bc9bc2e6a9c03765b
https://europepmc.org/articles/PMC230696/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání