Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Helene Trauchessec"'
1
Akademický článek
NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress
Autor: Chantal M. Maghames, Sofia Lobato-Gil, Aurelien Perrin, Helene Trauchessec, Manuel S. Rodriguez, Serge Urbach, Philippe Marin, Dimitris P. Xirodimas
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Protein NEDDylation increases upon proteotoxic stress but the function of this response remains to be elucidated. Here, the authors show that NEDDylation contributes to the cellular defence against proteotoxicity by promoting nuclear protein aggregat
Externí odkaz: https://doaj.org/article/85faf55d5a3042e781053e60dc0a6572
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2
Akademický článek
The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity
Autor: Aymeric P. Bailly, Aurelien Perrin, Marina Serrano-Macia, Chantal Maghames, Orsolya Leidecker, Helene Trauchessec, M.L. Martinez-Chantar, Anton Gartner, Dimitris P. Xirodimas
Publikováno v: Cell Reports, Vol 29, Iss 1, Pp 212-224.e8 (2019)
Summary: Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is
Externí odkaz: https://doaj.org/article/9fa4ba19a00e48b0a7dfd1435cd67332
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3
Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly
Autor: Toufic Kassouf, Rohit Shrivastava, Igor Meszka, Aymeric Bailly, Jolanta Polanowska, Helene Trauchessec, Jessica Mandrioli, Serena Carra, Dimitris P. Xirodimas
Publikováno v: Science Advances. 9
The elimination of aberrant inclusions is regarded as a therapeutic approach in neurodegeneration. In amyotrophic lateral sclerosis (ALS), mutations in proteins found within cytoplasmic condensates called stress granules (SGs) are linked to the forma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc01572c8bfed60d7cdb67b5655fd09a
https://doi.org/10.1126/sciadv.abq7585
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4
Targeting the deNEDDylating enzyme NEDP1 to ameliorate ALS phenotypes through Stress Granules dissolution
Autor: Toufic Kassouf, Rohit Shrivastava, Igor Meszka, Aymeric Bailly, Jolanta Polanowska, Helene Trauchessec, Jessica Mandrioli, Serena Carra, Dimitris P. Xirodimas
SummaryIn Amyotrophic Lateral Sclerosis (ALS) motor neuron disease, mutations in proteins that upon stress localize within cytoplasmic protein inclusions called Stress Granules (SGs), are linked to the formation of aberrant inclusions, which are rela
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bdec46d6619f47fc83b80db6d05f868
https://doi.org/10.1101/2023.01.06.522988
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5
Development of Nanobodies as first-in-class inhibitors for the NEDP1 deNEDDylating enzyme
Autor: Naima Abidi, Gholamreza Hassanzadeh-Ghassabeh, Helene Trauchessec, Martine Pugnière, Dimitris P. Xirodimas, Serge Muyldermans
Protein NEDDylation emerges as an important post-translational modification and an attractive target for therapeutic intervention. Modification of NEDD8 onto substrates is finely balanced by the co-ordinated activity of conjugating and deconjugating
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13da9b8561038ae2682f2b8111924a3
https://doi.org/10.1101/2020.03.20.999326
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7
The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity
Autor: Aurélien Perrin, Helene Trauchessec, Orsolya Leidecker, Aymeric P. Bailly, Chantal Maghames, Anton Gartner, Marina Serrano-Macia, Dimitris P. Xirodimas, María L. Martínez-Chantar
Publikováno v: Cell Reports
Cell Reports, 2019, 29 (1), pp.212-224.e8. ⟨10.1016/j.celrep.2019.08.070⟩
Cell Reports, Elsevier Inc, 2019, 29 (1), pp.212-224.e8. ⟨10.1016/j.celrep.2019.08.070⟩
Cell Reports, Vol 29, Iss 1, Pp 212-224.e8 (2019)
Summary Ubiquitin and ubiquitin-like chains are finely balanced by conjugating and de-conjugating enzymes. Alterations in this balance trigger the response to stress conditions and are often observed in pathologies. How such changes are detected is n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5d39ecc1dfd219f6cb99ac162e2d477
https://hal.umontpellier.fr/hal-02339558
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8
The NEDD8 cycle controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity
Autor: Chantal Maghames, Anton Gartner, Helene Trauchessec, María L. Martínez-Chantar, Orsolya Leidecker, Aurélien Perrin, Dimitris P. Xirodimas, Aymeric P. Bailly, Marina Serrano-Macia
SummaryUbiquitin and ubiquitin-like chains are finely balanced by the action of conjugating and de-conjugating enzymes. Alterations in this balance trigger signalling events required for the response to stress conditions and are often observed in pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa048c80e0717cd6a5314fde3e3378ac
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9
SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling
Autor: Muriel Busson, Lucile Canterel-Thouennon, Corinne Prévostel, Helene Trauchessec, Philippe Blache, Marc Ychou, Cyrine Rammah-Bouazza
Publikováno v: Oncotarget
Oncotarget, Impact journals, 2016, 7 (50), pp.82228-82243. ⟨10.18632/oncotarget.10573⟩
International audience; SOX9 inactivation is frequent in colorectal cancer (CRC) due to SOX9 gene mutations and/or to ectopic expression of MiniSOX9, a dominant negative inhibitor of SOX9. In the present study, we report a heterozygous L142P inactiva
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c4b6af24b216b9fbd2a3480b34f92d
https://hal.umontpellier.fr/hal-02298842/document
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10
Applying ecological and evolutionary theory to cancer : a long and winding road
Autor: Frédérique Billy, Annabelle Ballesta, Philippe Fort, Benoît Perthame, Serge Koscielny, Helene Trauchessec, Daniel Fisher, Céline Cosseau, Guillaume Mitta, Ruoping Tang, Patrice Lassus, W. Vainchenker, Christoph Grunau, Damien Grégoire, Corinne Quittau-Prévostel, Vjekoslav Dulic, Vitali Volpert, Eric Assenat, Michael E. Hochberg, Alexander Lorz, Philippe Blache, Thomas Lepoutre, François Delhommeau, Jean-Pierre Marie, Urszula Hibner, Peggy Raynaud, Frédéric Thomas, Jean Clairambault, Dorothée Missé, Fanny Fava, Eric Solary, Benjamin Roche, François Rousset, Emmanuel Vignal, Liliana Krasinska, Raphael Itzykson, Stephen Baghdiguian, Simon P. Daoust
Publikováno v: Evolutionary Applications
Evolutionary Applications, 2013, 6 (1), pp.1-10. ⟨10.1111/eva.12021⟩
Evolutionary Applications, Blackwell, 2013, 6 (1), pp.1-10. 〈10.1111/eva.12021〉
Evolutionary Applications, Blackwell, 2013, 6 (1), pp.1-10. ⟨10.1111/eva.12021⟩
International audience; Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with somatic cellular selection and evolution being the fundamental processes leading to malignancy and its many manifestations (neoangiogenes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0807ce3ecf0eaccdeba0beb7e010f491
http://www.documentation.ird.fr/hor/fdi:010058930
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