Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Helene Perrier"'
Autor:
Yves Girard, Dwight Macdonald, Deborah A. Nicoll-Griffith, Michel Gallant, Nathalie Chauret, Daniel Dube, Anthony Mastracchio, Laird A. Trimble, Kevin P. Bateman, José M. Silva, Stephen Day, Helene Perrier
Publikováno v:
Journal of Mass Spectrometry. 41:771-780
L-454,560 is a potent phospodiesterase 4 (PDE4) inhibitor which was identified as a development candidate for the treatment of asthma and chronic obstructive pulmonary disease (COPD). As part of the discovery of this compound, interspecies in vitro m
Autor:
Dwight Macdonald, Helene Perrier, Heather K. Dobson, Teresa R. Welch, Richard LeBlanc, Corey R. J. Stephenson
Publikováno v:
Tetrahedron Letters. 40:3119-3122
3-Amino-1,5-Hexadienes rearrange under anionic conditions to give a [1,3] product in addition to the [3,3] (Cope) product. With some substrates the regioselectivity of the reaction is strongly influenced by the solvent polarity.
Liquid-Phase Synthesis with Solid-Phase Workup: Application to Multistep and Combinatorial Syntheses
Autor:
Marc Labelle, Helene Perrier
Publikováno v:
The Journal of Organic Chemistry. 64:2110-2113
Autor:
M. Belley, Yves Leblanc, Kathleen M. Metters, M. McAuliffe, Nicole Sawyer, Claude Dufresne, Anthony W. Ford-Hutchinson, Robert Zamboni, Deborah Slipetz, Thomas R. Jones, Cheuk K. Lau, Robert N. Young, C.B. Pickett, C. Rochette, C. S. Mcfarlane, Zhaoyin Wang, Helene Perrier, Nathalie Ouimet, Marc Labelle, Yves Gareau, Xiang Yi Bin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2551-2556
Structure-activity studies leading to the discovery of a new series of non-quinoline cysLT 1 receptor (LTD 4 receptor) antagonists are described. These studies demonstrated that the quinoline ring system of montelukast ( 5 ) may be replaced by an app
Autor:
Helene Perrier, Khalid Abdullah, Wanda Cromlish, Michael J. Gresser, Serge Leger, Brian P. Kennedy
Publikováno v:
Protein Expression and Purification. 6:291-297
Cytosolic phospholipase A 2 (cPLA 2 ) plays a key role in the production of proinflammatory lipid mediators such as prostaglandins, thromboxane, and leukotrienes. cPLA 2 , an arachidonic acid-selective, 85-kDa protein has been purified, cloned, and p
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:519-522
An affinity column has been developed to provide a single step purification of the human recombinant baculovirus overexpressed cPLA 2 . The affinity matrix is based on the chemical structure of a potent inhibitor of cPLA 2 .
Autor:
Helene Perrier, Jilly F. Evans, Stella Charleson, Philip J. Vickers, Petpiboon Prasit, Serge Leger, Zhaoyin Wang
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 267:275-280
5-Lipoxygenase-activating protein is required for cellular leukotriene synthesis and is the target of the leukotriene biosynthesis inhibitors MK-886 (3-[1-(p-chlorophenyl)-5-isopropyl-3-tert-butylthio-1H0indol2-yl]-2,2-dimethylpropanoic acid) and MK-
Autor:
Philip K. Weech, Michael A. Bernstein, Helene Perrier, Nathalie Tremblay, Laird A. Trimble, Ian P. Street
Publikováno v:
Biochemistry. 32:12560-12565
Arachidonyl trifluoromethyl ketone (AACOCF3) is a slow- and tight-binding inhibitor of the human cytosolic phospholipase A2 (cPLA2) [Street et al. (1993) Biochemistry 32, 5935]. 19F and 13C NMR experiments have been carried out to elucidate the struc
Autor:
Farideh Ghomashchi, Nathalie Tremblay, Helene Perrier, F. Laliberte, Ian P. Street, Michael H. Gelb, Philip K. Weech, Zhaoyin Wang, Zheng Huang, Hung-Kuei Lin
Publikováno v:
Biochemistry. 32:5935-5940
A trifluoromethyl ketone analogue of arachidonic acid in which the COOH group is replaced with COCF3 (AACOCF3) was prepared and found to be a tight- and slow-binding inhibitor of the 85-kDa cytosolic human phospholipase A2 (cPLA2). Enzyme inhibition
Autor:
P. Prasit, Stella Charleson, Helene Perrier, Philip J. Vickers, Mark Abramovitz, Elizabeth Wong, Zhaoyin Wang, Martha E. Cox, Joseph A. Mancini
Publikováno v:
FEBS Letters. 318:277-281
5-Lipoxygenase-activating protein (FLAP) is an 18-kDa integral membrane protein which is essential for cellular leukotriene (LT) synthesis, and is the target of LT biosynthesis inhibitors. However, the mechanism by which FLAP activates 5-LO has not b