Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Helene Juteau"'
Autor:
Stephen M. Soisson, Tom Y.-H. Wu, Michel Gallant, Austin Chen, Dwight Macdonald, Daniel Dube, Robert Houle, Jean-Pierre Falgueyret, Renee Aspiotis, Dan McKay, Jean-François Lévesque, Patrick Roy, Helene Juteau, Sébastien Gagné, M. David Percival, Erich L. Grimm, Sebastien Laliberte, Patrick Lacombe, Elizabeth Cauchon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2430-2436
The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-de
Autor:
Christopher I. Bayly, Dan McKay, Tom Y.-H. Wu, Patrick Roy, Suzanna Liu, Michel Gallant, Austin Chen, Helene Juteau, Rejean Fortin, Daniel Dube, Renee Aspiotis, Patrick Lacombe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5822-5826
The discovery and SAR of a series of potent renin inhibitors possessing a novel biaryl scaffold are described herein. Molecular modeling revealed that the cyclopropylamide spacer present in 1 can be replaced by a simple, substituted aromatic ring suc
Autor:
Joel Rubin, Erich L. Grimm, Joseph A. Mancini, Richard Friesen, Diane Ethier, Denis Riendeau, Nathalie Méthot, Renee Aspiotis, Jocelyne Guay, Helene Juteau, Sébastien Guiral, Yves Gareau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3352-3355
A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the indole FLAP inhibitor MK-886. Compounds 23 and 30 inhibit mPGES-1 with potencies in the low nanomolar range and with selec
Autor:
Yves Gareau, Helene Juteau
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 178:1021-1026
1,2-Bis-triisopropylsilanylsulfanyl alkenes are readily converted to 1,3-dithiol-2-ones with phosgene under very mild acidic conditions at room temperature.
Publikováno v:
Tetrahedron. 57:5739-5750
The cross-coupling reaction of bis-triisopropylsilyl disulfide 1 on alkynes yielded 1,2-bis-triisopropylsilanylsulfanyl-alkenes 2, a new chemical class. A series of tri and tetrasubstituted olefins 2 were prepared and their behavior toward electrophi
Publikováno v:
Tetrahedron Letters. 38:1481-1484
β-Acyl glucuronides are readily prepared in two steps from allyl d -glucuronate 1 in 14 to 29% overall yields.
Publikováno v:
Organic Letters. 8:59-61
[reaction: see text] The chemical behavior of 1,2-bis-triisopropylsilanylsulfanyl alkenes 1 is relatively unexplored, and the weak sulfur-silicon bonds give rise to various transformations. Under acidic conditions (HCl) and in the presence of a Lewis
Publikováno v:
Tetrahedron Letters. 46:4547-4549
Substituted 3-(triisopropylsilyl)-2-naphthols are prepared by an aluminum chloride catalyzed condensation of phenyl acetyl chloride derivatives and triisopropylsilyl acetylene. The yields obtained are in the range of 41% to 67%. The reaction is regio
Autor:
Mélissa Arbour, Gavin Chit Tsui, Jean-Pierre Falgueyret, Pierre-André Fournier, Yongxin Han, Michel Gallant, Patrick Lacombe, Daniel Dube, Daniel Simard, Elizabeth Cauchon, Austin Chen, Renee Aspiotis, Suzanna Liu, René St-Jacques, Christophe Mellon, Erich L. Grimm, Yeeman K. Ramtohul, Helene Juteau
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(5)
The discovery and SAR of a series of potent renin inhibitors possessing a novel 3,4-diarylpiperidine scaffold are described herein. The resulting compound 38 exhibit low nanomolar plasma renin IC(50), had a clean CYP 3A4 profile and displayed micromo
Autor:
Marie-Claude Carrière, Yves Gareau, Nathalie Tremblay, Helene Juteau, Sonia Lamontagne, Danielle Denis, Marc Labelle, Kathleen M. Metters, Nicole Sawyer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:747-749
Potent and selective EP3 receptor ligands were found by making a library using solid-support chemistry. These compounds can be obtained by a Suzuki coupling reaction of a solid-supported benzyl bromide using various boronic acids. The yields obtained