Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Helene Jousset"'
Autor:
Ashton, Trent D., Ngo, Anna, Favuzza, Paola, Bullen, Hayley E., Gancheva, Maria R., Romeo, Ornella, Parkyn Schneider, Molly, Nguyen, Nghi, Steel, Ryan W.J., Duffy, Sandra, Lowes, Kym N., Sabroux, Helene Jousset, Avery, Vicky M., Boddey, Justin A., Wilson, Danny W., Cowman, Alan F., Gilson, Paul R., Sleebs, Brad E.
Publikováno v:
In Bioorganic Chemistry December 2021 117
Autor:
Nguyen, William, Dans, Madeline G., Ngo, Anna, Gancheva, Maria R., Romeo, Ornella, Duffy, Sandra, de Koning-Ward, Tania F., Lowes, Kym N., Sabroux, Helene Jousset, Avery, Vicky M., Wilson, Danny W., Gilson, Paul R., Sleebs, Brad E.
Publikováno v:
In European Journal of Medicinal Chemistry 15 March 2021 214
Autor:
Nguyen, William, Jacobson, Jonathan, Jarman, Kate E., Blackmore, Timothy R., Sabroux, Helene Jousset, Lewin, Sharon R., Purcell, Damian F., Sleebs, Brad E.
Publikováno v:
In European Journal of Medicinal Chemistry 1 June 2020 195
Akademický článek
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Autor:
Ian P. Street, Benjamin Cleary, Jonathan B. Baell, Jessica M. Strasser, Daniel L. Priebbenow, Hendrik Falk, Michael W. Parker, Susan A. Charman, H. Rachel Lagiakos, Brendon J. Monahan, Michael A. Walters, M.C. Chung, S.J. Hermans, Natalie L. Downer, Matthew E. Cuellar, Jayme L. Dahlin, Helene Jousset Sabroux, Tim Thomas, David J. Leaver, Swapna Varghese, Lian Xue, Karen L. White, Yuxin Sun, Prashant Mujumdar, Kasiram Katneni, Silvia Teguh, Anne K. Voss, Julie Sanchez, Kate E. Jarman, David M. Shackleford, Fei Huang, Ramesh Mudududdla, Nghi Nguyen
Publikováno v:
Journal of Medicinal Chemistry. 63:4655-4684
A high-throughput screen designed to discover new inhibitors of histone acetyltransferase KAT6A uncovered CTX-0124143 (1), a unique aryl acylsulfonohydrazide with an IC50 of 1.0 μM. Using this acylsulfonohydrazide as a template, we herein disclose t
Autor:
Isabelle S Lucet, James M. Murphy, Wil I. L. Lehmann, Annette V. Jacobsen, Diane Coursier, Guillaume Lessene, Cheree Fitzgibbon, Lung-Yu Liang, Kym N Lowes, Wilhelmus J A Kersten, Najoua Lalaoui, Jarrod J. Sandow, Gerard Manning, Andre L. Samson, Helene Jousset Sabroux, Emma J. Petrie, Samuel N. Young, Andrew I. Webb, Amanda E. Au
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3309-3319.e5 (2019)
Summary: Necroptotic cell death has been implicated in many human pathologies and is thought to have evolved as an innate immunity mechanism. The pathway relies on two key effectors: the kinase receptor-interacting protein kinase 3 (RIPK3) and the te
Autor:
Paul R. Gilson, Ornella Romeo, Anna Ngo, Vicky M. Avery, Kym N Lowes, Tania F. de Koning-Ward, Madeline G Dans, Danny W. Wilson, Maria R. Gancheva, Sandra Duffy, Brad E. Sleebs, William Nguyen, Helene Jousset Sabroux
Publikováno v:
European journal of medicinal chemistry. 214
The emerging resistance to combination therapies comprised of artemisinin derivatives has driven a need to identify new antimalarials with novel mechanisms of action. Central to the survival and proliferation of the malaria parasite is the invasion o
Autor:
Kate E. Jarman, Damian F. J. Purcell, William Nguyen, Brad E. Sleebs, Sharon R Lewin, Timothy R. Blackmore, Jonathan C. Jacobson, Helene Jousset Sabroux
Publikováno v:
European journal of medicinal chemistry. 195
A persistent latent reservoir of virus in CD4+ T cells is a major barrier to cure HIV. Activating viral transcription in latently infected cells using small molecules is one strategy being explored to eliminate latency. We previously described the us
Autor:
Peter E. Czabotar, Kate E. Jarman, Alan F. Cowman, Brad E. Sleebs, Justin A Boddey, Jennifer K. Thompson, Richard Bestel de Lezongard, Helene Jousset Sabroux, William Nguyen, Anthony N. Hodder, Matthew T. O'Neill
Publikováno v:
European Journal of Medicinal Chemistry. 154:182-198
Plasmepsin V is an aspartyl protease that plays a critical role in the export of proteins bearing the Plasmodium export element (PEXEL) motif (RxLxQ/E/D) to the infected host erythrocyte, and thus the survival of the malaria parasite. Previously, dev
Autor:
Hayley E. Bullen, Helene Jousset Sabroux, Sandra Duffy, Justin A Boddey, Ryan W.J. Steel, Maria R. Gancheva, Kym N Lowes, Paul R. Gilson, Alan F. Cowman, Vicky M. Avery, Trent D. Ashton, Brad E. Sleebs, Anna Ngo, Danny W. Wilson, Molly Parkyn Schneider, Paola Favuzza, Ornella Romeo, Nghi Nguyen
Publikováno v:
Bioorganic Chemistry. 117:105359
Malaria is a devastating disease caused by Plasmodium parasites. Emerging resistance against current antimalarial therapeutics has engendered the need to develop antimalarials with novel structural classes. We recently described the identification an