Study protocol: effects of exercise booster sessions on preservation of exercise-induced adaptations in persons with multiple sclerosis, a multicentre randomised controlled trial—the MS BOOSTER trial

Autor: Helen Dawes, Jesper Lundbye-Jensen, Tobias Sejbaek, Viktoria Papp, Ulrik Dalgas, Finn Sellebjerg, Lars G Hvid, Laurits Taul-Madsen, Jeppe Romme Christensen, Rikke Ratzer, Kristina Bacher Svendsen, Helene Højsgaard Chow

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Introduction Multiple sclerosis (MS) causes a broad range of symptoms, with physical function being one of the most disabling consequences according to patients themselves. Exercise effectively improves lower extremity physical function. Nonetheless,

Externí odkaz: https://doaj.org/article/9f41ba5b5dbf4cca938e747885bc466b

Cannabis-Based Medicine for Neuropathic Pain and Spasticity—A Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial

Autor: Julie Schjødtz Hansen, Stefan Gustavsen, Homayoun Roshanisefat, Matthias Kant, Fin Biering-Sørensen, Claus Andersen, Anna Olsson, Helene Højsgaard Chow, Nasrin Asgari, Julie Richter Hansen, Helle Hvilsted Nielsen, Rikke Middelhede Hansen, Thor Petersen, Annette Bang Oturai, Finn Sellebjerg, Eva Aggerholm Sædder, Helge Kasch, Peter Vestergaard Rasmussen, Nanna Brix Finnerup, Kristina Bacher Svendsen

Publikováno v: Pharmaceuticals, Vol 16, Iss 8, p 1079 (2023)

Patients with multiple sclerosis (MS) and spinal cord injury (SCI) commonly sustain central neuropathic pain (NP) and spasticity. Despite a lack of consistent evidence, cannabis-based medicine (CBM) has been suggested as a supplement treatment. We ai

Externí odkaz: https://doaj.org/article/4eaeb1d85b0443b5ac6c45703acf19c2

Peripheral helper T cells in the pathogenesis of multiple sclerosis

Autor: Rikke Holm Hansen, Helene Højsgaard Chow, Jacob Talbot, Sophie Buhelt, Marie Nathalie Nickelsen Hellem, Jørgen Erik Nielsen, Finn Thorup Sellebjerg, Marina Rode von Essen

Publikováno v: Multiple sclerosis (Houndmills, Basingstoke, England). 28(9)

Background: Peripheral helper T cells (Tph) are likely implicated in the pathogenesis of various inflammatory diseases. Tph cells share functions with follicular helper T cells, including plasma cell differentiation and antibody production. Objective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070cab27fe8b08b8c3e6ae88931bec1c
https://pubmed.ncbi.nlm.nih.gov/35112578

Increased Intrathecal Activity of Follicular Helper T Cells in Patients With Relapsing-Remitting Multiple Sclerosis

Autor: Rikke Holm Hansen, Jacob Talbot, Helene Højsgaard Chow, Malene Bredahl Hansen, Sophie Buhelt, Sebastian Herich, Nicholas Schwab, Marie Nathalie Nickelsen Hellem, Joergen Erik Nielsen, Finn Sellebjerg, Marina Rode von Essen

Publikováno v: Holm Hansen, R, Talbot, J, Højsgaard Chow, H, Bredahl Hansen, M, Buhelt, S, Herich, S, Schwab, N, Hellem, M N N, Nielsen, J E, Sellebjerg, F & von Essen, M R 2022, ' Increased Intrathecal Activity of Follicular Helper T Cells in Patients With Relapsing-Remitting Multiple Sclerosis ', Neurology(R) neuroimmunology & neuroinflammation, vol. 9, no. 5, e200009. . https://doi.org/10.1212/NXI.0000000000200009

Background and ObjectivesFollicular helper T (Tfh) cells play a critical role in protective immunity helping B cells produce antibodies against foreign pathogens and are likely implicated in the pathogenesis of various autoimmune diseases. The purpos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::659ea29d1b61dd17ced8c44cfb2e013a
https://doi.org/10.1212/nxi.0000000000200009

Dimethyl Fumarate Treatment in Patients With Primary Progressive Multiple Sclerosis

Autor: Jacob Talbot, Morten Blinkenberg, Lisbet Marstrand, Mie Reith Mahler, Marina Rode von Essen, Finn Sellebjerg, Per Soelberg Sørensen, Rikke Holm Hansen, Jeppe Romme Christensen, Theis Lange, Sophie Buhelt, Henrik Lundell, Helene Højsgaard Chow, Hartwig R. Siebner, Camilla Gøbel Madsen

Publikováno v: Højsgaard Chow, H, Talbot, J, Lundell, H, Gøbel Madsen, C, Marstrand, L, Lange, T, Mahler, M R, Buhelt, S, Holm Hansen, R, Blinkenberg, M, Romme Christensen, J, Soelberg Sørensen, P, Rode von Essen, M, Siebner, H R & Sellebjerg, F 2021, ' Dimethyl Fumarate Treatment in Patients With Primary Progressive Multiple Sclerosis : A Randomized, Controlled Trial ', Neurology(R) neuroimmunology & neuroinflammation, vol. 8, no. 5, pp. 1-10 . https://doi.org/10.1212/NXI.0000000000001037

Background and ObjectiveTo study whether dimethyl fumarate is superior to placebo in decreasing CSF concentrations of neurofilament light chain (NFL) in patients with primary progressive MS (PPMS).MethodsIn the double-blind, placebo-controlled phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140fe243fc5d623327222e6ec67fe0da
https://doi.org/10.1212/nxi.0000000000001037