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pro vyhledávání: '"Helene E B Geiller"'
Autor:
Helene E B Geiller, Adam Harvey, Rhiannon E Jones, Julia W Grimstead, Kez Cleal, Eric A Hendrickson, Duncan M Baird
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010485 (2022)
Telomerase activity is the principal telomere maintenance mechanism in human cancers, however 15% of cancers utilise a recombination-based mechanism referred to as alternative lengthening of telomeres (ALT) that leads to long and heterogenous telomer
Externí odkaz:
https://doaj.org/article/c81ea65d1fdd4e569bfe1d5f11bd2374
Autor:
Anna M Rose, Tomas Goncalves, Siobhan Cunniffe, Helene E B Geiller, Thomas Kent, Sam Shepherd, Malitha Ratnaweera, Roderick J O’Sullivan, Richard J Gibbons, David Clynes
Publikováno v:
Nucleic Acids Research.
Telomere maintenance is a hallmark of malignant cells and allows cancers to divide indefinitely. In some cancers, this is achieved through the alternative lengthening of telomeres (ALT) pathway. Whilst loss of ATRX is a near universal feature of ALT-