Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Helene Damhofer"'
Autor:
Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom, Gillian M. Morrison, Philip F. Hughes, Timothy Haystead, Steven M. Pollard, Kristian Helin
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)
Abstract Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic approaches, we performed CRISPR/Cas9 knockout screens and discovered TGFβ activat
Externí odkaz:
https://doaj.org/article/9c882069fd714df8a02c424b20d4f84c
Autor:
Sanne ten Hoorn, Cynthia Waasdorp, Martijn G. H. van Oijen, Helene Damhofer, Anne Trinh, Lan Zhao, Lisanne J. H. Smits, Sanne Bootsma, Gabi W. van Pelt, Wilma E. Mesker, Linda Mol, Kaitlyn K. H. Goey, Miriam Koopman, Jan Paul Medema, Jurriaan B. Tuynman, Inti Zlobec, Cornelis J. A. Punt, Louis Vermeulen, Maarten F. Bijlsma
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Recently it has been recognized that stromal markers could be used as a clinically relevant biomarker for therapy response and prognosis. Here, we report on a serum marker for stromal activation, A Disintegrin and Metalloprotease
Externí odkaz:
https://doaj.org/article/8ad6d424ab5a409ca212adae406cab37
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100575- (2021)
Summary: Protein degradation technologies represent a powerful functional genomics tool, allowing fast and controllable target protein depletion. Establishing these systems requires a knock-in of the degradation tag into both endogenous target gene a
Externí odkaz:
https://doaj.org/article/a1859a67b9bc414588ca5376f7d5d55f
Autor:
Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke ten Brink, Dick J. Richel, C. Arnold Spek
Publikováno v:
Molecular Medicine, Vol 23, Iss 1, Pp 13-23 (2017)
Abstract Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives the progression and induces the ch
Externí odkaz:
https://doaj.org/article/6e50a7b861c34a498c0aed80d8226043
Autor:
Andrea L. Johnstone, Helene Damhofer, Ole N. Jensen, Michael-Christopher Keogh, Aliaksandra Radzisheuskaya, Yingqian Zhan, Richard Koche, Vasily V. Grinev, Daria Shlyueva, Vladimir Gorshkov, Ronald C. Hendrickson, Kristian Helin, Sergey Kovalchuk, Keli L. Rodriguez, Pavel V. Shliaha
Publikováno v:
Radzisheuskaya, A, Shliaha, P V, Grinev, V V, Shlyueva, D, Damhofer, H, Koche, R, Gorshkov, V, Kovalchuk, S, Zhan, Y, Rodriguez, K L, Johnstone, A L, Keogh, M-C, Hendrickson, R C, Jensen, O N & Helin, K 2021, ' Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis ', Molecular Cell, vol. 81, no. 8, pp. 1749-1765.e8 . https://doi.org/10.1016/j.molcel.2021.02.012
Radzisheuskaya, A, Shliaha, P V, Grinev, V V, Shlyueva, D, Damhofer, H, Koche, R, Gorshkov, V, Kovalchuk, S, Zhan, Y, Rodriguez, K L, Johnstone, A L, Keogh, M C, Hendrickson, R C, Jensen, O N & Helin, K 2021, ' Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis ', Molecular Cell, vol. 81, no. 8, pp. 1749-1765.e8 . https://doi.org/10.1016/j.molcel.2021.02.012
Mol Cell
Radzisheuskaya, A, Shliaha, P V, Grinev, V V, Shlyueva, D, Damhofer, H, Koche, R, Gorshkov, V, Kovalchuk, S, Zhan, Y, Rodriguez, K L, Johnstone, A L, Keogh, M C, Hendrickson, R C, Jensen, O N & Helin, K 2021, ' Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis ', Molecular Cell, vol. 81, no. 8, pp. 1749-1765.e8 . https://doi.org/10.1016/j.molcel.2021.02.012
Mol Cell
Summary Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in Drosophila, the functions of H4K16ac and two KAT8-containing protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe3ef6ffe7afe53ff13473b14698e7
https://portal.findresearcher.sdu.dk/da/publications/3c30878e-5994-484c-a75b-48f2827b2915
https://portal.findresearcher.sdu.dk/da/publications/3c30878e-5994-484c-a75b-48f2827b2915
Autor:
Veronique L. Veenstra, Eline C. Soer, Marc G. Besselink, Sjors Klompmaker, Xin Wang, Anne Steins, Cynthia Waasdorp, Gerrit K. J. Hooijer, Johannes B G Halfwerk, Frederike Dijk, Jan Koster, Olivier R. Busch, Lan Zhao, Jan Paul Medema, Sander R. van Hooff, Mark P. G. Dings, Johanna A. M. G. Tol, Hanneke W. M. van Laarhoven, Louis Vermeulen, Lennart B. van Rijssen, Hanneke Wilmink, Lieke Welling, Marc J. van de Vijver, Helene Damhofer, Joanne Verheij, Maarten F. Bijlsma, Marco Marzano
Publikováno v:
Scientific reports, 10(1):337. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Dijk, F, Veenstra, V L, Soer, E C, Dings, M P G, Zhao, L, Halfwerk, J B, Hooijer, G K, Damhofer, H, Marzano, M, Steins, A, Waasdorp, C, Busch, O R, Besselink, M G, Tol, J A, Welling, L, van Rijssen, L B, Klompmaker, S, Wilmink, H W, van Laarhoven, H W, Medema, J P, Vermeulen, L, van Hooff, S R, Koster, J, Verheij, J, van de Vijver, M J, Wang, X & Bijlsma, M F 2020, ' Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems ', Scientific Reports, vol. 10, no. 1, 337 . https://doi.org/10.1038/s41598-019-56826-9
Scientific Reports
Scientific Reports, 10(1):337. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Dijk, F, Veenstra, V L, Soer, E C, Dings, M P G, Zhao, L, Halfwerk, J B, Hooijer, G K, Damhofer, H, Marzano, M, Steins, A, Waasdorp, C, Busch, O R, Besselink, M G, Tol, J A, Welling, L, van Rijssen, L B, Klompmaker, S, Wilmink, H W, van Laarhoven, H W, Medema, J P, Vermeulen, L, van Hooff, S R, Koster, J, Verheij, J, van de Vijver, M J, Wang, X & Bijlsma, M F 2020, ' Unsupervised class discovery in pancreatic ductal adenocarcinoma reveals cell-intrinsic mesenchymal features and high concordance between existing classification systems ', Scientific Reports, vol. 10, no. 1, 337 . https://doi.org/10.1038/s41598-019-56826-9
Scientific Reports
Scientific Reports, 10(1):337. Nature Publishing Group
Pancreatic ductal adenocarcinoma (PDAC) has the worst prognosis of all common cancers. However, divergent outcomes exist between patients, suggesting distinct underlying tumor biology. Here, we delineated this heterogeneity, compared interconnectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8323c123368a0a75228d3755e03402df
https://doi.org/10.1038/s41598-019-56826-9
https://doi.org/10.1038/s41598-019-56826-9
Autor:
Ilse Dingjan, Jan Paul Medema, Helene Damhofer, Cynthia Waasdorp, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven, Allard C. van der Wal, Veronique L. Veenstra
Publikováno v:
Cellular Oncology (2011. Print), 41, 4, pp. 427-437
Cellular oncology, 41(4), 427-437. IOS Press
Cellular Oncology (Dordrecht)
Cellular Oncology (2011. Print), 41, 427-437
Cellular oncology, 41(4), 427-437. IOS Press
Cellular Oncology (Dordrecht)
Cellular Oncology (2011. Print), 41, 427-437
Purpose Basal cell carcinoma (BCC) is one of the most common skin cancers, and is typically driven by an aberrantly activated Hedgehog (Hh) pathway. The Hh pathway is regulated by interactions between the Patched-1 (Ptch1) and Smoothened (Smo) recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7d4fd58d561d51a39e9331c0bcf523
https://doi.org/10.1007/s13402-018-0381-9
https://doi.org/10.1007/s13402-018-0381-9
Autor:
Cynthia Waasdorp, Anne Steins, Hanneke W. M. van Laarhoven, Veronique L. Veenstra, Jan Paul Medema, Maarten F. Bijlsma, Helene Damhofer, Hemant M. Kocher
Publikováno v:
Molecular Oncology
Molecular oncology, 11(8), 1050-1064. Elsevier
Molecular oncology, 11(8), 1050-1064. Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor‐promoting and tumor‐suppressing properties. This is underscored by the disappointing results of stroma targeting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b5d0df68e5a485873a18ad847c8d3d
https://doi.org/10.1002/1878-0261.12073
https://doi.org/10.1002/1878-0261.12073
Autor:
Peter Bailey, Maarten F. Bijlsma, Frederike Dijk, M.J. van de Vijver, Hanneke Wilmink, Andrew V. Biankin, R. Jiang, H.W.M. van Laarhoven, J. S. Li, Helene Damhofer, O.R.C. Busch, Cynthia Waasdorp, Daniel W. Pierce, Hemant M. Kocher, Marc G. Besselink, David K. Chang, Jan Paul Medema, Veronique L. Veenstra, L.B. van Rijssen
Publikováno v:
Oncogenesis, 7(11):87. Nature Publishing Group
Oncogenesis
Veenstra, V L, Damhofer, H, Waasdorp, C, van Rijssen, L B, van de Vijver, M J, Dijk, F, Wilmink, H W, Besselink, M G, Busch, O R, Chang, D K, Bailey, P J, Biankin, A V, Kocher, H M, Medema, J P, Li, J S, Jiang, R, Pierce, D W, van Laarhoven, H W M & Bijlsma, M F 2018, ' ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy ', Oncogenesis, vol. 7, no. 11, 87 . https://doi.org/10.1038/s41389-018-0096-9
Oncogenesis, Vol 7, Iss 11, Pp 1-11 (2018)
Oncogenesis
Veenstra, V L, Damhofer, H, Waasdorp, C, van Rijssen, L B, van de Vijver, M J, Dijk, F, Wilmink, H W, Besselink, M G, Busch, O R, Chang, D K, Bailey, P J, Biankin, A V, Kocher, H M, Medema, J P, Li, J S, Jiang, R, Pierce, D W, van Laarhoven, H W M & Bijlsma, M F 2018, ' ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy ', Oncogenesis, vol. 7, no. 11, 87 . https://doi.org/10.1038/s41389-018-0096-9
Oncogenesis, Vol 7, Iss 11, Pp 1-11 (2018)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma that harbors tumor-promoting properties. No good biomarkers exist to monitor the effect of stromal targeting therapies or to predict response. We set out to identify such non
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2157ec8c528e05a77c053a34a9745600
https://research.vumc.nl/en/publications/4fe3e1ce-18aa-4d64-9e4f-49ef240cec14
https://research.vumc.nl/en/publications/4fe3e1ce-18aa-4d64-9e4f-49ef240cec14
Autor:
Jonas W. Højfeldt, Ole N. Jensen, Helene Damhofer, Berthe M. Willumsen, Faizaan Mohammad, Kristian Helin, Anne Laugesen, Andrey Tvardovskiy, Lin Hedehus
Publikováno v:
Højfeldt, J W, Laugesen, A, Willumsen, B M, Damhofer, H, Hedehus, L, Tvardovskiy, A, Mohammad, F, Jensen, O N & Helin, K 2018, ' Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2 ', Nature Structural and Molecular Biology, vol. 25, no. 3, pp. 225-232 . https://doi.org/10.1038/s41594-018-0036-6
Nature structural & molecular biology
Nature structural & molecular biology
Polycomb repressive complex 2 (PRC2) catalyzes methylation on lysine 27 of histone H3 (H3K27) and is required for maintaining transcriptional patterns and cellular identity, but the specification and maintenance of genomic PRC2 binding and H3K27 meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63a058e432b522abaf0ea1f9255008c
https://findresearcher.sdu.dk:8443/ws/files/151772965/emss_75815.pdf
https://findresearcher.sdu.dk:8443/ws/files/151772965/emss_75815.pdf