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pro vyhledávání: '"Helene C Dujardin"'
Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7
Autor:
Helene C Dujardin, Florence Mishellany, Odile Burlen-Defranoux, Régis Peffault de Latour, Antonio Bandeira, James P. Di Santo, Paulo José Cardoso Vieira, Julien Zuber, Rute Marques, Ana Cumano
Publikováno v:
Blood. 108:2300-2306
Mice lacking interleukin-7 (IL-7–/– mice) have no signs of autoimmune disease, contrary to other models of lymphopenia. We investigated whether the absence of disease was due to the fact that IL-7 is dispensable for the ontogeny, function, and ho
Autor:
Laurent Boucontet, Ana Cumano, Odile Burlen-Defranoux, Paulo Vieira, Helene C. Dujardin, Antonio Bandeira
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 101(40)
Thymectomy at day 3 after birth leads to autoimmune disease in some genetic backgrounds. Disease is thought to be caused by the lack/paucity of regulatory T cells. We show that 3-day-old mice already contain a significant compartment ofFoxp3-expressi