Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Helene Botella"'
Autor:
Alexandra H. Miller, Frances Marks, Luming Chan, Helene Botella, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT Iron scavenging is required for full virulence of mycobacterial pathogens. During infection, the host immune response restricts mycobacterial access to iron, which is essential for bacterial respiration and DNA synthesis. The Mycobacterium t
Externí odkaz:
https://doaj.org/article/7d3f4a8023bb46768a12876ed6100852
Autor:
Ruojun Wang, Kaj Kreutzfeldt, Helene Botella, Julien Vaubourgeix, Dirk Schnappinger, Sabine Ehrt
Publikováno v:
eLife, Vol 8 (2019)
The ability of Mycobacterium tuberculosis (Mtb) to persist in its host is central to the pathogenesis of tuberculosis, yet the underlying mechanisms remain incompletely defined. PerM, an integral membrane protein, is required for persistence of Mtb i
Externí odkaz:
https://doaj.org/article/4a432131af104ff39e65407df128baf9
Autor:
Helene Botella, Guangli Yang, Ouathek Ouerfelli, Sabine Ehrt, Carl F. Nathan, Julien Vaubourgeix
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT Peptidoglycan (PG), a polymer cross-linked by d-amino acid-containing peptides, is an essential component of the bacterial cell wall. We found that a fluorescent d-alanine analog (FDAA) incorporates chiefly at one of the two poles in Mycobac
Externí odkaz:
https://doaj.org/article/fa96f2621a094f4e9df20bec19046749
Autor:
Helene Botella, Carl Nathan, Kyu Y. Rhee, Sarah M. Schrader, Sabine Ehrt, Robert S. Jansen, Julien Vaubourgeix
Publikováno v:
Science Advances
Science Advances, 7, 1-17
Science Advances, 7, 35, pp. 1-17
Science Advances, 7, 1-17
Science Advances, 7, 35, pp. 1-17
Disruption of a metabolic pathway causes tolerance, high persistence, and MIC-shifted resistance to diverse antibiotics.
A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment b
A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc9cca1e082da6fd24a79613979e2ce
http://hdl.handle.net/10044/1/90679
http://hdl.handle.net/10044/1/90679
Autor:
Hideki Makinoshima, Naomi Song, Helene Botella, Julien Vaubourgeix, Weizhen Xu, Michael S. Glickman, Sabine Ehrt, Myung Hee Lee
Publikováno v:
The EMBO Journal. 36:536-548
Mycobacterium tuberculosis (Mtb) can persist in the human host in a latent state for decades, in part because it has the ability to withstand numerous stresses imposed by host immunity. Prior studies have established the essentiality of the periplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e2b954069ce457d4f935645e4637fe
https://doi.org/10.15252/embj.201695028
https://doi.org/10.15252/embj.201695028
Autor:
Sabine Ehrt, Helene Botella, Dirk Schnappinger, Ruojun Wang, Julien Vaubourgeix, Kaj Kreutzfeldt
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The ability of Mycobacterium tuberculosis (Mtb) to persist in its host is central to the pathogenesis of tuberculosis, yet the underlying mechanisms remain incompletely defined. PerM, an integral membrane protein, is required for persistence of Mtb i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b25ab45aa419b4406984767e282bc4
http://europepmc.org/articles/PMC6872210
http://europepmc.org/articles/PMC6872210
Autor:
Shumin Tan, Roger Calderon, Marcel A. Behr, Eric Oldfield, Shoko Wakabayashi, Xinxin Feng, Jacob A. Mayfield, Tan Yun Cheng, Adriaan J. Minnaard, Anita E. Grootemaat, David C. Young, Emilie Layre, Michael B. Reed, Jeffrey Buter, Marwan Ghanem, Nicole N. van der Wel, Eric J. Rubin, Megan Murray, Helene Botella, Sahadevan Raman, Alexandrea K. Ramnarine, Noman Siddiqi, Sabine Ehrt, D. Branch Moody, Thomas Ennis, Barry B. Snider, Ashmir R. Plantijn, Amanda J. Martinot, Joyce Wang, Rachel N. Cotton
Publikováno v:
Nature chemical biology, 15(9), 889-899. Nature Publishing Group
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2019, 15 (9), pp.889-899. ⟨10.1038/s41589-019-0336-0⟩
Nat Chem Biol
Nature Chemical Biology, 15(9), 889-+. Nature Publishing Group
Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2019, 15 (9), pp.889-899. ⟨10.1038/s41589-019-0336-0⟩
Nat Chem Biol
Nature Chemical Biology, 15(9), 889-+. Nature Publishing Group
Mycobacterium tuberculosis (Mtb) is the world's most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. In the present study 1-TbAd has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6416073d041da94ceeee9b0b365d93b1
https://pure.amc.nl/en/publications/mycobacterium-tuberculosis-releases-an-antacid-that-remodels-phagosomes(d1de61e4-4b86-471d-a920-93473591aff7).html
https://pure.amc.nl/en/publications/mycobacterium-tuberculosis-releases-an-antacid-that-remodels-phagosomes(d1de61e4-4b86-471d-a920-93473591aff7).html
Autor:
Carl Nathan, Dirk Schnappinger, Gang Lin, Xiuju Jiang, Michael Unser, Tania J. Lupoli, Nicolas Chenouard, John D. McKinney, Ouathek Ouerfelli, Olivia Mariani, Julien Vaubourgeix, Guangli Yang, Neeraj Dhar, Helene Botella
Publikováno v:
Cell Host & Microbe. 17(2):178-190
SummaryMycobacterium tuberculosis (Mtb) defends itself against host immunity and chemotherapy at several levels, including the repair or degradation of irreversibly oxidized proteins (IOPs). To investigate how Mtb deals with IOPs that can neither be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d656dce2a161c9d675a282a8d4160d
Autor:
Carl Nathan, Nan Zhao, Helene Botella, Jennifer L. Small, Christina Eberhart, Crystal M. Darby, Hugh Rosen, Benjamin F. Cravatt, Timothy P. Spicer, Xiuju Jiang, Peter Hodder, Sabine Ehrt, Daniel A. Bachovchin, Anna E Speers, Erin D. Anderson, Virneliz Fernandez-Vega, Kristin Burns-Huang, Dale L. Boger
Publikováno v:
ACS Chemical Biology
Mycobacterium tuberculosis (Mtb) maintains its intrabacterial pH (pHIB) near neutrality in the acidic environment of phagosomes within activated macrophages. A previously reported genetic screen revealed that Mtb loses this ability when the mycobacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed3f1e044d10fcf4d5ebca742b3d574
https://doi.org/10.1021/cb500746z
https://doi.org/10.1021/cb500746z
Autor:
Dirk Schnappinger, Padmini Salgame, Shuang Song, Amir Liba, Ruojun Wang, Nichole Goodsmith, Julien Vaubourgeix, Kamlesh Bhatt, Xinzheng V. Guo, Omar Vandal, Sabine Ehrt, Helene Botella
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 11, Iss 2, p e1004645 (2015)
PLoS Pathogens, Vol 11, Iss 2, p e1004645 (2015)
The identification of Mycobacterium tuberculosis genes necessary for persistence in vivo provides insight into bacterial biology as well as host defense strategies. We show that disruption of M. tuberculosis membrane protein PerM (Rv0955) resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1579f00042f6c179661d8dcfa4612cb1
https://doi.org/10.1371/journal.ppat.1004645
https://doi.org/10.1371/journal.ppat.1004645