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pro vyhledávání: '"Helene Bayer"'
Autor:
Jeffrey C. Gildersleeve, Martin R. Berger, Sven Stanzel, Katharina Essig, Martin Frank, Cristina Voss, Helene Bayer
Publikováno v:
Journal of Biological Chemistry. 287:35873-35886
Riproximin is a cytotoxic type II ribosome-inactivating protein showing high selectivity for tumor cell lines. Its binding to cell surface glycans is crucial for subsequent internalization and cytotoxicity. In this paper, we describe a unique mechani
Publikováno v:
Protein Expression and Purification. 82:97-105
Highly pure riproximin was isolated from the fruit kernels of Ximenia americana, a defined, seasonally available and potentially unlimited herbal source. The newly established purification procedure included an initial aqueous extraction, removal of
Publikováno v:
Biotechnology advances. 32(6)
The development of new anticancer drugs is a salient problem and the traditional use of plants is a potentially rich source of information for detecting new molecules with antineoplastic activity. Riproximin is a recently detected cytotoxic type II r