Infections increase the risk of decompensation and death in patients with early alcohol-related liver disease

Autor: Stine Johansen, Simon Langkjær, Ditlev Nytoft Rasmussen, Mads Israelsen, Nikolaj Torp, Katrine Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Camilla Dalby Hansen, Katrine Thorhauge, Peter Andersen, Sönke Detlefsen, Helene Bæk Juel, Ulrik Stenz Justesen, Torben Hansen, Aleksander Krag, Maja Thiele, Ema Anastasiadou, Manimozhian Arumugam, Peer Bork, Jenny Presto, Hans Israelsen, Morten Karsdal, Cristina Legido-Quigley, Hans Olav Melberg, Jonel Trebicka, Mathias Mann, Jelle Matthijnssens

Publikováno v: JHEP Reports, Vol 6, Iss 4, Pp 101016- (2024)

Background & Aims: Infections are frequent in patients with cirrhosis and worsen prognosis. We evaluated the incidence of infections and their impact on decompensation and death in patients with early alcohol-related liver disease (ALD) during long-t

Externí odkaz: https://doaj.org/article/0139fe8a16594c2aabc3b535edca94a1

Personalised human albumin in patients with cirrhosis and ascites: design and rationale for the ALB-TRIAL - a randomised clinical biomarker validation trial

Autor: Torben Hansen, Pere Ginès, Wim Laleman, Peer Bork, Vishal C Patel, Debbie Shawcross, Robert Schierwagen, Camila Alvarez-Silva, Florence Servant, Jonel Trebicka, Benjamin Lelouvier, Manimozhiyan Arumugam, Ed J Kuijper, Frank Erhard Uschner, Michael Praktiknjo, Mária Papp, Saeed Shoaie, Michael Kühn, Maja Thiele, Paolo Angeli, Joan Claria, Vicente Arroyo, Manolo Laiola, Benoit Quinquis, Sabine Klein, Minneke J Coenraad, François Fenaille, Debbie Lindsay Shawcross, Wenyi Gu, Adria Juanola, Elisa Pose, Aleksander Krag, Ivica Letunic, Alain Pruvost, Hervé M Blottière, Nathalie Galleron, Cristina López-Vicario, Peter V Treit, Matthias Mann, Jelle Matthijnssens, Mark J W Mcphail, Philipp E Geyer, Hans Olav Melberg, Stefanie Kandels, Cristina Sánchez-Garrido, Florence A Castelli, Christophe Junot, Lars Asphaug, Mads Israelsen, Helene Bæk Juel, Nikolaj Torp, Minneke Coenraad, Marko Korenjak, Ferran Aguilar-Parera, Patricia Sierra-Casas, Anna Bosch-Comas, David Tornai, Boglarka Balogh, Katrine Holtz Thorhauge, Casper Sahl Poulsen, Thea Van Rossum, Suguru Nishijima, Marisa I Keller, Diënty H M Hazenbrink, Sylvain Dechaumet, Sebastian D Burz, Emeline Chu-Van, Etienne Thévenot, Florian A Rosenberger, Sebastian Van Blerk, Amirouche Ouzerdine, Alain Roulet, Jean-Louis-Marie Insonere, Céline Serres, Mathieu Almeida, Florence Thirion, Camille Champion, Chaima Ezzine, Célia Chamignon, Nicolas Lapaque, Mamadou Gabou Thiam, Lore Van Espen, Quinten R Ducarmon, Annelotte GC Broekhoven, Susan Fischer, Romy Zwittink, Itziar De Lecuona, Giulio Rosati, Celia Fuentes-Chust, Arben Merkoçi, Massimo Urban, José Alfonso Marrugo-Ramirez, Ameli Schwalber, Lindsey Ann Edwards, Victoria Tatiana Kronsten, David Moyes, Azadeh Harzandi, Jordi Gratacós-Ginès, Martina Pérez-Guasch, Miriam Pellón, Bryan Contreras, Max Brol, Manfred Fobker, Renata Antonina Feuerborn

Publikováno v: BMJ Open, Vol 14, Iss 2 (2024)

Introduction Human albumin is used in the treatment of complications of cirrhosis. However, the use of long-term human albumin administration is costly and resource demanding for both patients and healthcare systems. A precision medicine approach wit

Externí odkaz: https://doaj.org/article/289f12a27d2047adb5cb758cb2809703

Multi-component prime-boost Chlamydia trachomatis vaccination regimes induce antibody and T cell responses and accelerate clearance of infection in a non-human primate model

Autor: Emma Lorenzen, Vanessa Contreras, Anja W. Olsen, Peter Andersen, Delphine Desjardins, Ida Rosenkrands, Helene Bæk Juel, Benoit Delache, Sebastien Langlois, Constance Delaugerre, Christophe Joubert, Nathalie Dereuddre-Bosquet, Cécile Bébéar, Bertille De Barbeyrac, Arabella Touati, Paul F. McKay, Robin J. Shattock, Roger Le Grand, Frank Follmann, Jes Dietrich

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

It is of international priority to develop a vaccine against sexually transmitted Chlamydia trachomatis infections to combat the continued global spread of the infection. The optimal immunization strategy still remains to be fully elucidated. The aim

Externí odkaz: https://doaj.org/article/8eba49251cfe46ee8889846d67ba7fb9

A Previously Undescribed Highly Prevalent Phage Identified in a Danish Enteric Virome Catalog

Autor: Lore Van Espen, Emilie Glad Bak, Leen Beller, Lila Close, Ward Deboutte, Helene Bæk Juel, Trine Nielsen, Deniz Sinar, Lander De Coninck, Christine Frithioff-Bøjsøe, Cilius Esmann Fonvig, Suganya Jacobsen, Maria Kjærgaard, Maja Thiele, Anthony Fullam, Michael Kuhn, Jens-Christian Holm, Peer Bork, Aleksander Krag, Torben Hansen, Manimozhiyan Arumugam, Jelle Matthijnssens

Publikováno v: mSystems, Vol 6, Iss 5 (2021)

ABSTRACT Gut viruses are important, yet often neglected, players in the complex human gut microbial ecosystem. Recently, the number of human gut virome studies has been increasing; however, we are still only scratching the surface of the immense vira

Externí odkaz: https://doaj.org/article/8c16f8759bf740f9bd1c21aeaa78c976

Sphingolipids Are Depleted in Alcohol-Related Liver Fibrosis

Autor: Maja Thiele, Tommi Suvitaival, Kajetan Trošt, Min Kim, Andressa de Zawadzki, Maria Kjaergaard, Ditlev Nytoft Rasmussen, Katrine Prier Lindvig, Mads Israelsen, Sönke Detlefsen, Peter Andersen, Helene Bæk Juel, Trine Nielsen, Stella Georgiou, Vicky Filippa, Michael Kuhn, Suguru Nishijima, Lucas Moitinho-Silva, Peter Rossing, Jonel Trebicka, Ema Anastasiadou, Peer Bork, Torben Hansen, Cristina Legido-Quigley, Aleksander Krag, Mathias Mann, Jelle Matthijnssens, Manimozhiyan Arumugam, Roland Henrar, Hans Israelsen, Morten Karsdal, Hans Olav Melberg

Publikováno v: Gastroenterology. 164:1248-1260

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e389fca66a940fd6a578e445bca21f28
https://doi.org/10.1053/j.gastro.2023.02.023