Circulating microRNA changes in patients with impaired glucose regulation

Autor: Helene A. Fachim, Camila M. Loureiro, Kirk Siddals, Caroline F Dalton, Gavin P. Reynolds, J. Martin Gibson, Zhen Bouman Chen, Adrian H. Heald

Publikováno v: Adipocyte, Vol 9, Iss 1, Pp 443-453 (2020)

We analysed if levels of four miRNAs would change after a lifestyle intervention involving dietary and exercises in prediabetes. MiRNAs previously shown to be associated with diabetes (Let-7a, Let-7e, miR-144 and miR-92a) were extracted from serum pr

Externí odkaz: https://doaj.org/article/a32d02250bf248a7aaeeb77bf5f8f5a1

Relationship between the Plasma Proteome and Changes in Inflammatory Markers after Bariatric Surgery

Autor: Helene A. Fachim, Zohaib Iqbal, J. Martin Gibson, Ivona Baricevic-Jones, Amy E. Campbell, Bethany Geary, Akheel A. Syed, Antony Whetton, Handrean Soran, Rachelle P. Donn, Adrian H. Heald

Publikováno v: Cells, Vol 10, Iss 10, p 2798 (2021)

Severe obesity is a disease associated with multiple adverse effects on health. Metabolic bariatric surgery (MBS) can have significant effects on multiple body systems and was shown to improve inflammatory markers in previous short-term follow-up stu

Externí odkaz: https://doaj.org/article/b3a95d62be8c4287a6a8e7c3e8189c26

O ciclo da vesícula sináptica, espinhos dendríticos e a transdução de sinal

Autor: Suélen Merlo, Janaína Brusco, Fernando E. Padovan-Neto, Carlos J.S. Rohner, Érika T. Ikeda, Jana B. de Ross, Lezio S. Bueno Júnior, Rafael N. Ruggiero, Helene A. Fachim, Jorge E. Moreira

Publikováno v: Medicina, Vol 44, Iss 2 (2011)

No sistema nervoso, a sinapse é a estrutura que permite a um neurônio passar um sinal elétrico ouquímico a outro neurônio ou outra célula (muscular ou glandular). A palavra sinapse vem de "synaptein",palavra que Sir Charles Scott Sherrington e

Externí odkaz: https://doaj.org/article/0f399e37eb7c46c1b3b5fe2f050cc68e

Subchronic PCP effects on DNA methylation and protein expression of NMDA receptor subunit genes in the prefrontal cortex and hippocampus of female rats

Autor: Camila M Loureiro, Helene A Fachim, Michael K Harte, Caroline F Dalton, Gavin P Reynolds

Publikováno v: Journal of Psychopharmacology. 36:238-244

Background: N-methyl-d-aspartate receptor (NMDAR) dysfunction is implicated in schizophrenia, and NMDAR antagonists, such as phencyclidine (PCP), can induce behaviours that mimic aspects of the disorder. Aims: We investigated DNA methylation of Grin1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e51ea3db1e42c36f4b8ab8e56fa404
https://doi.org/10.1177/02698811211069109

Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation

Autor: J. Martin Gibson, Helene A Fachim, Adrian H. Heald, Handrean Soran, Kirk Siddals, Nagaraj Malipatil, Caroline F. Dalton, Rachelle Donn, Safwaan Adam, Gabriela Y C Moreno

Publikováno v: Adipocyte
Fachim, H A, Siddals, K, Malipatil, N, Donn, R P, Moreno, G Y, Dalton, C F, Adam, S, Soran, H, Gibson, J M & Heald, A H 2020, ' Lifestyle intervention in individuals with impaired glucose regulation affects Caveolin-1 expression and DNA methylation ', Adipocyte, vol. 9, no. 1, pp. 96-107 . https://doi.org/10.1080/21623945.2020.1732513
Adipocyte, Vol 9, Iss 1, Pp 96-107 (2020)

© 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Aims: We investigated whether a lifestyle intervention could influence expression and DNA methylation of diabetes-related genes in patients with impai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de0f25021b58bb0be49e1da23b7ef8a
https://doi.org/10.1080/21623945.2020.1732513