Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Helene Baribault"'
Autor:
Tristan W. Fowler, Troy L. Mitchell, Claudia Y. Janda, Liqin Xie, Shengjiang Tu, Hui Chen, Haili Zhang, Jingjing Ye, Brian Ouyang, Tom Z. Yuan, Sung-Jin Lee, Maureen Newman, Nikita Tripuraneni, Erica S. Rego, Devin Mutha, Archana Dilip, Meghah Vuppalapaty, Helene Baribault, Wen-Chen Yeh, Yang Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Antibody-based Wnt agonists are able to phenocopy Wnt signaling in vivo resulting in increased bone density, repair, and strength. Here, the authors show that Wnt agonists can reverse bone loss associated with ovariectomy and build stronger bone when
Externí odkaz:
https://doaj.org/article/f832347476cc4872864883076749da99
Autor:
Liqin Xie, Russell B. Fletcher, Diksha Bhatia, Darshini Shah, Jacqueline Phipps, Shalaka Deshmukh, Haili Zhang, Jingjing Ye, Sungjin Lee, Lucas Le, Maureen Newman, Hui Chen, Asmiti Sura, Suhani Gupta, Laura E. Sanman, Fan Yang, Weixu Meng, Helene Baribault, Geertrui F. Vanhove, Wen-Chen Yeh, Yang Li, Chenggang Lu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology. 14:435-464
Current management of inflammatory bowel disease leaves a clear unmet need to treat the severe epithelial damage. Modulation of Wnt signaling might present an opportunity to achieve histological remission and mucosal healing when treating IBD. Exogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2328b014de90d749bf328ce57fad9c13
https://doi.org/10.1016/j.jcmgh.2022.05.003
https://doi.org/10.1016/j.jcmgh.2022.05.003
Autor:
Xinle Wu, Jun Zhang, Hongfei Ge, Jamila Gupte, Helene Baribault, Ki Jeong Lee, Bryan Lemon, Suzanne Coberly, Yan Gong, Zheng Pan, Ingrid C. Rulifson, Jonitha Gardner, William G. Richards, Yang Li
Publikováno v:
EBioMedicine, Vol 2, Iss 3, Pp 214-224 (2015)
The polarization of tissue resident macrophages toward the alternatively activated, anti-inflammatory M2 phenotype is believed to positively impact obesity and insulin resistance. Here we show that the soluble form of the extracellular domain (ECD) o
Externí odkaz:
https://doaj.org/article/636e27540bd84af88e2304e36b892dff
Autor:
Troy L. Mitchell, Yang Li, Tom Z. Yuan, Meghah Vuppalapaty, Nikita Tripuraneni, Fowler Tristan William, Sung-Jin Lee, Jingjing Ye, Haili Zhang, Erica S. Rego, Hui Chen, Archana Dilip, Liqin Xie, Helene Baribault, Janda Claudia Yvonne, Wen-Chen Yeh, Shengjiang Tu, Maureen Newman, Brian Ouyang, Devin Mutha
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The Wnt signaling pathway is intricately connected with bone mass regulation in humans and rodent models. We designed an antibody-based platform that generates potent and selective Wnt mimetics. Using this platform, we engineer bi-specific Wnt mimeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b417c9384484d7b1c272b1f89bb76314
https://doaj.org/article/f832347476cc4872864883076749da99
https://doaj.org/article/f832347476cc4872864883076749da99
Publikováno v:
F1000Research, Vol 5 (2016)
Gpr21 KO mice generated with Gpr21 KO ES cells obtained from Deltagen showed improved glucose tolerance and insulin sensitivity when fed a high fat diet. Further mRNA expression analysis revealed changes in Rabgap1 levels and raised the possibility t
Externí odkaz:
https://doaj.org/article/9aff18b6572245e88ca85f00c44fd46c
Publikováno v:
F1000Research, Vol 5 (2016)
Gpr21 KO mice generated with Gpr21 KO ES cells obtained from Deltagen showed improved glucose tolerance and insulin sensitivity when fed a high fat diet. Further mRNA expression analysis revealed changes in Rabgap1 levels and raised the possibility t
Externí odkaz:
https://doaj.org/article/4ff4591f419b4563b863df0224a4a643
Autor:
Ingrid C Rulifson, Ping Cao, Li Miao, David Kopecky, Linda Huang, Ryan D White, Kim Samayoa, Jonitha Gardner, Xiaosu Wu, Kui Chen, Trace Tsuruda, Oliver Homann, Helene Baribault, Harvey Yamane, Tim Carlson, Jed Wiltzius, Yang Li
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147254 (2016)
Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis. IA
Externí odkaz:
https://doaj.org/article/cc92adda697c42418dff19e2c29370d8
Autor:
Hongfei Ge, Jennifer Weiszmann, Jeff D. Reagan, Jamila Gupte, Helene Baribault, Tibor Gyuris, Jin-Long Chen, Hui Tian, Yang Li
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 4, Pp 797-803 (2008)
GPR81 is an orphan G protein-coupled receptor (GPCR) that has a high degree of homology to the nicotinic acid receptor GPR109A. GPR81 expression is highly enriched and specific in adipocytes. However, the function and signaling properties of GPR81 ar
Externí odkaz:
https://doaj.org/article/763679ce5669428d860903630eebdab3
Autor:
Hongfei Ge, Jonitha Gardner, Xiaosu Wu, Ingrid Rulifson, Jinghong Wang, Yumei Xiong, Jingjing Ye, Edward Belouski, Ping Cao, Jie Tang, Ki Jeong Lee, Suzanne Coberly, Xinle Wu, Jamila Gupte, Lynn Miao, Li Yang, Natalie Nguyen, Bei Shan, Wen-Chen Yeh, Murielle M Véniant, Yang Li, Helene Baribault
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0126924 (2015)
Trefoil factor 3 (TFF3), also called intestinal trefoil factor or Itf, is a 59 amino acid peptide found as a homodimer predominantly along the gastrointestinal tract and in serum. TFF3 expression is elevated during gastrointestinal adenoma progressio
Externí odkaz:
https://doaj.org/article/80d053555e6a4ed7aa6585d3c09320bb
Autor:
Chenggang Lu, Russell Fletcher, Jacqueline L. Phipps, Darshini Shah, Shalaka Deshmukh, Trevor Fisher, Helene Baribault, Wen-Chen Yeh, Yang Li
Publikováno v:
Gastroenterology. 162:S-1225
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48cc709275ff8cff82b622d5d97569c4
https://doi.org/10.1016/s0016-5085(22)63620-5
https://doi.org/10.1016/s0016-5085(22)63620-5