Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Helene, Schlecht"'
Autor:
D. Gareth Evans, Emma R. Woodward, George J. Burghel, Sophie Allen, Beth Torr, Monica Hamill, Grace Kavanaugh, Mike Hubank, Stephen Bremner, Christopher I. Jones, Helene Schlecht, Susan Astley, Sarah Bowers, Sarah Gibbons, Helen Ruane, Caroline Fosbury, Sacha J. Howell, Claire Forde, Fiona Lalloo, William G. Newman, Miriam J. Smith, Anthony Howell, Clare Turnbull, Ashu Gandhi
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 100849- (2024)
Purpose: To assess the contribution of germline pathogenic variants (PVs) in population-based series of breast cancers and the best strategy to improve detection rates. Methods: Three cohort studies were utilized, including a hospital-based series id
Externí odkaz:
https://doaj.org/article/3e798b711ae8405f937d2e6d36c02588
Autor:
Robert D. Morgan, George J. Burghel, Helene Schlecht, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Joseph Shaw, Sudha Desai, Gordon C. Jayson, Emma R. Woodward, D. Gareth R. Evans
Publikováno v:
Cancers, Vol 16, Iss 1, p 177 (2023)
Patients diagnosed with epithelial ovarian cancer may undergo reflex tumour BRCA1/2 testing followed by germline BRCA1/2 testing in patients with a positive tumour test result. This testing model relies on tumour BRCA1/2 tests being able to detect al
Externí odkaz:
https://doaj.org/article/3122f59188784a6ab441ba4e0329ec9f
Autor:
Camilla Coulson-Gilmer, Robert D. Morgan, Louisa Nelson, Bethany M. Barnes, Anthony Tighe, René Wardenaar, Diana C. J. Spierings, Helene Schlecht, George J. Burghel, Floris Foijer, Sudha Desai, Joanne C. McGrail, Stephen S. Taylor
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-26 (2021)
Abstract Background Patients with ovarian cancer often present at advanced stage and, following initial treatment success, develop recurrent drug-resistant disease. PARP inhibitors (PARPi) are yielding unprecedented survival benefits for women with B
Externí odkaz:
https://doaj.org/article/f3fbd598ccd148c7a8595d1081bbfe91
Autor:
Robert D. Morgan, George J. Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R. Clamp, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Emma R. Woodward, Fiona Lalloo, Emma J. Crosbie, Richard J. Edmondson, Helene Schlecht, Gordon C. Jayson, D. Gareth R. Evans
Publikováno v:
Cancers, Vol 15, Iss 3, p 730 (2023)
Women diagnosed with non-mucinous high-grade epithelial ovarian cancer (EOC) in England are often reflex-tested for germline and tumour BRCA1/2 variants. The value of germline BRCA1/2 testing in women diagnosed aged ≥80 is questionable. We performe
Externí odkaz:
https://doaj.org/article/226d8028d5794a148682355578cb1be9
Autor:
Dhivya Chandrasekaran, Monika Sobocan, Oleg Blyuss, Rowan E. Miller, Olivia Evans, Shanthini M. Crusz, Tina Mills-Baldock, Li Sun, Rory F. L. Hammond, Faiza Gaba, Lucy A. Jenkins, Munaza Ahmed, Ajith Kumar, Arjun Jeyarajah, Alexandra C. Lawrence, Elly Brockbank, Saurabh Phadnis, Mary Quigley, Fatima El Khouly, Rekha Wuntakal, Asma Faruqi, Giorgia Trevisan, Laura Casey, George J. Burghel, Helene Schlecht, Michael Bulman, Philip Smith, Naomi L. Bowers, Rosa Legood, Michelle Lockley, Andrew Wallace, Naveena Singh, D. Gareth Evans, Ranjit Manchanda
Publikováno v:
Cancers, Vol 13, Iss 17, p 4344 (2021)
We present findings of a cancer multidisciplinary-team (MDT) coordinated mainstreaming pathway of unselected 5-panel germline BRCA1/BRCA2/RAD51C/RAD51D/BRIP1 and parallel somatic BRCA1/BRCA2 testing in all women with epithelial-OC and highlight the d
Externí odkaz:
https://doaj.org/article/a118176a5e304ad38cd052d2442e48ce
Autor:
Robert D Morgan, Andrew R Clamp, Bethany M Barnes, Kirsten Timms, Helene Schlecht, Laura Yarram-Smith, Yvonne Wallis, Mikel Valganon-Petrizan, Suzanne MacMahon, Rhian White, Sian Morgan, Sarah McKenna, Emma Hudson, Laura Tookman, Angela George, Ranjit Manchanda, Sudha S Sundar, Shibani Nicum, James D Brenton, Rebecca S Kristeleit, Susana Banerjee, Iain A McNeish, Jonathan A Ledermann, Stephen S Taylor, D Gareth R Evans, Gordon C Jayson
Publikováno v:
Morgan, R D, Clamp, A R, Barnes, B M, Timms, K, Schlecht, H, Yarram-Smith, L, Wallis, Y, Valganon-Petrizan, M, Macmahon, S, White, R, Morgan, S, Mckenna, S, Hudson, E, Tookman, L, George, A, Manchanda, R, Sundar, S S, Nicum, S, Brenton, J D, Kristeleit, R S, Banerjee, S, Mcneish, I A, Ledermann, J A, Taylor, S S, Evans, D G & Jayson, G C 2023, ' Homologous recombination deficiency in newly diagnosed FIGO stage III/IV high-grade epithelial ovarian cancer: a multi-national observational study ', International Journal of Gynecological Cancer . https://doi.org/10.1136/ijgc-2022-004211
ObjectiveOlaparib plus bevacizumab maintenance therapy improves survival outcomes in women with newly diagnosed, advanced, high-grade ovarian cancer with a deficiency in homologous recombination. We report data from the first year of routine homologo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb793cc9d756983a33fbb917e7372e8
https://doi.org/10.1136/ijgc-2022-004211
https://doi.org/10.1136/ijgc-2022-004211
Autor:
D Gareth Evans, George J Burghel, Helene Schlecht, Elaine F Harkness, Ashu Gandhi, Sacha J Howell, Anthony Howell, Claire Forde, Fiona Lalloo, William G Newman, Miriam Jane Smith, Emma Roisin Woodward
Publikováno v:
Evans, D G, Burghel, G J, Schlecht, H, Harkness, E F, Gandhi, A, Howell, S J, Howell, A, Forde, C, Lalloo, F, Newman, W G, Smith, M J & Woodward, E R 2023, ' Detection of pathogenic variants in breast cancer susceptibility genes in bilateral breast cancer ', Journal of Medical Genetics . https://doi.org/10.1136/jmg-2023-109196
PurposeTo investigate the frequency of germline pathogenic variants (PVs) in women with bilateral breast cancer.MethodsWe undertookBRCA1/2andCHEK2c.1100delC molecular analysis in 764 samples and a multigene panel in 156. Detection rates were assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e860400de5ccb1fe9afaacddc39578
https://research.manchester.ac.uk/en/publications/f25b9fb4-cc44-4af4-a68c-3c17a503ffd0
https://research.manchester.ac.uk/en/publications/f25b9fb4-cc44-4af4-a68c-3c17a503ffd0
Autor:
D Gareth Evans, Siva Sithambaram, Elke Maria van Veen, George J Burghel, Helene Schlecht, Elaine F Harkness, Helen Byers, Jamie M Ellingford, Ashu Gandhi, Sacha J Howell, Anthony Howell, Claire Forde, Fiona Lalloo, William G Newman, Miriam Jane Smith, Emma Roisin Woodward
Publikováno v:
Evans, D G, Sithambaram, S, van Veen, E M, Burghel, G J, Schlecht, H, Harkness, E, Byers, H J, Ellingford, J, Gandhi, A, Howell, S J, Howell, T, Forde, C, Lalloo, F, Newman, W, Smith, M J & Woodward, E 2022, ' Differential involvement of germline pathogenic variants in breast cancer genes between DCIS and low-grade invasive cancers ', Journal of Medical Genetics . https://doi.org/10.1136/jmg-2022-108790
PurposeTo investigate frequency of germline pathogenic variants (PVs) in women with ductal carcinoma in situ (DCIS) and grade 1 invasive breast cancer (G1BC).MethodsWe undertookBRCA1/2analysis in 311 women with DCIS and 392 with G1BC and extended pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115b11b250e0606d60e9ac5e69e7b595
https://research.manchester.ac.uk/en/publications/c94290d8-af40-4cdf-aef9-8aa182ee5e54
https://research.manchester.ac.uk/en/publications/c94290d8-af40-4cdf-aef9-8aa182ee5e54
Autor:
Robert D Morgan, George J Burghel, Nicola Flaum, Michael Bulman, Philip Smith, Andrew R Clamp, Jurjees Hasan, Claire Mitchell, Zena Salih, Emma R Woodward, Fiona Lalloo, Joseph Shaw, Sudha Desai, Emma J Crosbie, Richard J Edmondson, Helene Schlecht, Andrew J Wallace, Gordon C Jayson, D Gareth R Evans
Publikováno v:
Morgan, R D, Burghel, G J, Flaum, N, Bulman, M, Smith, P, Clamp, A R, Hasan, J, Mitchell, C, Salih, Z, Woodward, E R, Lalloo, F, Shaw, J, Desai, S, Crosbie, E J, Edmondson, R J, Schlecht, H, Wallace, A J, Jayson, G C & Evans, D G R 2022, ' Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer ', Journal Of Clinical Pathology . https://doi.org/10.1136/jcp-2022-208369
Burghel, GJ, Flaum, N, Bulman, M, Clamp, AR, Hasan, J, Salih, Z, Lalloo, F, Shaw, J, Desai, S & Crosbie, EJ 2022, ' Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer ', Journal Of Clinical Pathology . https://doi.org/10.1136/jcp-2022-208369
Burghel, GJ, Flaum, N, Bulman, M, Clamp, AR, Hasan, J, Salih, Z, Lalloo, F, Shaw, J, Desai, S & Crosbie, EJ 2022, ' Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer ', Journal Of Clinical Pathology . https://doi.org/10.1136/jcp-2022-208369
AimsClinical guidelines recommend testing both germline and tumour DNA for BRCA1/2 pathogenic variants (PVs) in non-mucinous high-grade epithelial ovarian cancer (NMEOC). In this study, we show that some tumour BRCA1/2 PVs are highly likely to be som
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76400a7c00ab211c13628e824ace32a4
https://www.mendeley.com/catalogue/f0b4bc28-8cbb-3b9b-a445-022fcc539057/
https://www.mendeley.com/catalogue/f0b4bc28-8cbb-3b9b-a445-022fcc539057/
Autor:
Cristina Perez‐Becerril, Andrew J. Wallace, Helene Schlecht, Naomi L. Bowers, Philip T. Smith, Carolyn Gokhale, Helen Eaton, Chris Charlton, Rachel Robinson, Ruth S. Charlton, D. Gareth Evans, Miriam J. Smith
Publikováno v:
Human mutation. 43(10)
Schwannomatosis comprises a group of hereditary tumor predisposition syndromes characterized by, usually benign, multiple nerve sheath tumors, which frequently cause severe pain that does not typically respond to drug treatments. The most common schw